4- n-alkylanilino quinazoline derivative and its preparation

Abstract

Abstract NEW MATERIAL:The titled compound expressed by formula I (R 1 is H, halogen, CF 3 or NO 2 ; R 2 is H, lower alkyl, lower alkoxy or halogen; R 3 is lower alkyl group), and its pharmacologically acceptable acid addition salt. EXAMPLE: 4-(N-methylanilino)-7-trifluoromethylquinazoline. USE: An analgesic and anti-inflammatory agent usually in a daily dose of 50W2,000mg per adult administered once or several times. PROCESS: A 4-halogenoquinazoline derivative of formula II is reacted with an equimolar amount of an N-alkylaniline derivative of formula III in a solvent under heating to give the compound of formula I, which can be converted into a pharmacologically acceptable acid addition salt, if necessary, by the conventional method. COPYRIGHT: (C)1981,JPO&Japio

Inventors

• 👤 Shinsaku Kobayashi
• 👤 Katsuo Kamoshita
• 👤 Shigeki Nagai
• 👤 Takeo Honda
• 👤 Kiroku Oda
• 👤 Katsutoshi Fujii
• 👤 Takashi Furubayashi
• 👤 Mikio Kojima

Bibliographic Details