Recovery of interferon

Abstract

Abstract PURPOSE: To rocover interferon readily in high yields, by adsorbing a human interferon-containing aqueous solution by a specific adsorbent, followed by eluting it in a specified solution. CONSTITUTION: A human interferon-containing aqueous solution induced and obtained from a human derived cell(e.g., human lymph cell, human fibroblast, and human established lymphoblast) is brought into contact with a silicic acid(SiO 2 )- containing composition(e.g., bentonite, terra alba, and magnesium aluminosilicate) so that interferon is adsorbed by the composition. Adsorbed interferon is eluted in an aqueous solution containing both nonionic surface active agent(e.g., polyoxyethylene-based one) and an acriflavine(e.g., acrinol) to recover interferon. COPYRIGHT: (C)1981,JPO&Japio

Inventors

• 👤 Yatsuhiro Kamimura
• 👤 Hirobumi Arimura
• 👤 Yutaka Morise
• 👤 Satoru Funakoshi
• 👤 Tadakazu Suyama

Bibliographic Details