Substituted quinoline-carboxylic acid derivative

Abstract

Abstract NEW MATERIAL:A compound (or ester) of formula I: [R is (substituted) lower alkyl, alkenyl, alkynyl group, etc.; X and Y are H or halogen and not H at the same time; n is 0, 1, or 2; A is (substituted) amino, OH, or (substituted) cyclic amino group], and its salt. EXAMPLE: 1-Ethyl-1,4-dihydro-7-( 4-dimethylamino-1-piperidinyl )-6-fluoro-4-oxoquinoline-3-carboxylic acid. USE: Useful as antibacterials having a great antibacterial activity against Gram-positive and Gram-negative bacteria. PROCESS: A compound of formula II: (Z is halogen) is reacted with a compound of formula III in the presence of a solvent at room temperature of 200°C to give the objective compound of formula I. COPYRIGHT: (C)1980,JPO&Japio

Inventors

• 👤 Tsutomu Irikura
• 👤 Seigo Suzue
• 👤 Hiroshi Koga

Bibliographic Details