Carbazoyl derivative, its production and maillard reaction inhibitor containing the same derivative as active component

Abstract

Abstract NEW MATERIAL:The compound of formula I (R<1a> is single bond, 1-6C alkylene or 2-6C alkenylene; R<2a> is halogen, OH, nitro, amino, 1-4C alkyl, carbon ring or heterocyclic group; R<1a> and R<2a> may together form 1-12C alkyl, etc; R<3a> is H, 1-6C alkyl, phenyl, benzyl, etc; Xa is single bond or imino; etc.) or its acid addition salt. EXAMPLE:4-(4-Nitrophenyl)semicarbazide hydrochloride. USE:A Maillard reaction inhibitor. It is useful as a remedy and preventive for various complications of diabetes, e.g., coronary cardiopathy, peripheral circulation disorder, cerebrovascular disorder, diabetic neurosis, arteriosclerosis, cataract and retinopathy. PREPARATION:The objective compound of formula I can be produced by reacting an isocyanate compound of formula II with a compound of formula III in a solvent such as diethyl ether at 0-40 deg.C.

Inventors

• 👤 Shuichi Ouchida
• 👤 大内田　修一
• 👤 Masaaki Toda
• 👤 正明 戸田
• 👤 Tsumoru Miyamoto
• 👤 宮本　積

Bibliographic Details