1-aminomethylphosphonic acid derivative, its manufacture, and drug composition

Abstract

Abstract N-(23-Vinblastinoyl) derivatives of 1-aminomethylphosphonic acid, of general formula I: <IMAGE> <??>In which: - R1 denotes a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkylene radical containing from 1 to 6 carbon atoms, an arylalkyl radical of 7 to 10 carbon atoms capable of carrying as substituent on the aromatic ring a halogen atom, a hydroxyl radical or an alkyl or alkoxy radical, each containing from 1 to 5 carbon atoms, a 2-indolylmethyl radical, a 4-imidazolylmethyl radical, or an alkoxycarbonylmethyl radical containing from 3 to 11 carbon atoms, - each of R2 and R3, which are identical or different, denotes a linear or branched alkyl radical containing from 1 to 4 carbon atoms, in the form of mixture of diastereo isomers or of pure isomers, their Nb'-oxides and their addition salts with a pharmaceutically acceptable inorganic or organic acid. <??>These compounds are antitumoral agents.

Inventors

• 👤 Gilbert Lavielle
• 👤 ギルベール　ラビエレ
• 👤 Patrick Hautefaye
• 👤 パトリック　オウテファイエ
• 👤 Claude Cudennec
• 👤 クロード　クデネック

Bibliographic Details