Patent EP0913167A2 successfully refreshed from Google Patents.
EP0913167A2
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Improved targeted hysteresis hyperthermia as a method for treating tissue
Assignee: Sirtex Medical Pty Ltd
•
Filing: 1998-10-27
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Granted: —
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Expires: 2018-10-27
Abstract
Abstract The present invention provides an improved method for treatment of diseased tissue, which comprises the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5 x 10 -8 J.m./A.g, when rotational magnetic field conditions are equal to or less than about 5 x 10 8 A/m.s; (ii) delivering the magnetic material to a patient's diseased tissue; and (iii) exposing the magnetic material to a rotational magnetic field with a frequency of greater than about 10kHz and a field strength selected such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5 x 10 7 A/s to generate hysteresis heat in the diseased tissue.
Inventors
- 👤 Bruce Nathaniel Gray
- 👤 Stephen Keith Jones
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 22:20
CPC Classifications
A; A61; A61N; A61N2/00; A61N2/12; A61N1/00; A61N1/40; A61N1/403; A61N1/406; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5094
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
112 words
A method for heating a substance, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating
efficiency of at least about 4.5 x 10 -8 J.m./A.g, when rotational magnetic
field conditions are equal to or less than about 5 x 10 8 A/m.s; (ii) inserting the magnetic material in the substance; and (iii) exposing the magnetic material to a rotational magnetic field with a
frequency of greater than about 10kHz and a field strength selected such
that the product of field strength, frequency and the radius of the exposed
region is less than about 7.5 x 10 7 A/s to generate hysteresis heat in the
substance.
Claim 2
Dependent Claim
12 words
A method according to claim 1 wherein the substance is non-biological
material.
Claim 3
Independent Claim
113 words
A method for treating biological tissue, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating
efficiency of at least about 4.5 x 10 -8 J.m./A.g, when rotational magnetic
field conditions are equal to or less than about 5 x 10 8 A/m.s; (ii) introducing the magnetic material into the biological tissue; and (iii) exposing the magnetic material to a rotational magnetic field with a
frequency of greater than about 10kHz and a field strength selected such
that the product of field strength, frequency and the radius of the exposed
region is less than about 7.5 x 10 7 A/s to generate hysteresis heat in the
tissue.
Claim 4
Dependent Claim
17 words
A method according to claim 3 wherein the tissue contains cancerous growths
or one or more tumours.
Claim 5
Independent Claim
19 words
A method according to any preceding claim, wherein the magnetic material is
bound in a matrix to form microcapsules.
Claim 6
Dependent Claim
30 words
A method according to claim 5 wherein the microcapsules are of a size large
enough to pass through a patient's vasculature network and become
dispersed and embolised within diseased tissue.
Claim 7
Dependent Claim
24 words
A method according to claim 5 or claim 6, wherein the microcapsules are
delivered to the diseased tissue in conjunction with a vasoactive agent.
Claim 8
Independent Claim
32 words
A method according to any preceding claim, wherein the magnetic material
is constrained by a matrix material that does not adversely effect hysteresis
or eddy current heating properties of the magnetic particles.
Claim 9
Independent Claim
33 words
A method according to any one of claims 5 to 7, wherein the microcapsules
are adapted to bind or absorb or contain a cytotoxic material which is released
upon heating of the microcapsule.
Claim 10
Independent Claim
37 words
A method according to any one of claims 5 to 7 or 9, wherein a plurality of
different microcapsule classes are employed in the method, which classes
each contain different magnetic materials which have different MHE
properties.
Claim 11
Dependent Claim
24 words
A method according to claim 10, wherein at least one of the classes of
microcapsules is adapted to release chemical, chemotherapeutic or
therapeutic substances.
Claim 12
Independent Claim
28 words
A method according to any one of claims 3 to 11, wherein step (iii) is carried
out for sufficient time to raise the tissue's temperature above about 42°C.
Claim 13
Independent Claim
34 words
A method according to any one of claims 3 to 12, wherein steps (i) to (iii) are
repeated until the tissue or part thereof has been killed or treated sufficiently
to ameliorate the disease.
Claim 14
Independent Claim
39 words
A method according to any preceding claim, wherein the magnetic material
has a MHE of greater than about 7 x 10 -8 J.m./A.g, when magnetic field
conditions are equal to or less than about 5 x 10 8 A/m.s.
Claim 15
Independent Claim
39 words
A method according to any preceding claim, wherein the magnetic material
has a MHE of greater than about 1 x 10 -7 J.m./A.g, when magnetic field
conditions are equal to or less than about 5 x 10 8 A/m.s.
Claim 16
Independent Claim
33 words
A method according to any preceding claim, wherein the magnetic material
are ferromagnetic or ferrimagnetic materials which include elements selected
from the group consisting of iron, nickel, cobalt, manganese, arsenic,
antimony and bismuth.
Claim 17
Independent Claim
93 words
A method according to any preceding claim, wherein the magnetic material is
selected from at least one of the following classes of material: CrO 2 ; gamma-ferric
oxide (both cobalt treated and non-treated); metallic iron, cobalt or
nickel; ferrites of general form MO.Fe 2 O 3 where M is a bivalent metal such as
Mg, Mn, Fe, Co, Ni, Cu, Zn, Cd or Li; cobalt treated ferrites; or
magnetoplumbite type oxides (M type) with general form MO.6Fe 2 O 3 where
M is a large divalent ion such as Ba, Sr or Pb.
Claim 18
Independent Claim
23 words
A method according to any preceding claim, wherein the magnetic material is
Co treated gamma-ferric oxide, a cobalt treated ferrite or chromium dioxide.
Claim 19
Independent Claim
24 words
A method according to any preceding claim, wherein the magnetic material is
delivered to the diseased tissue via the arterial or venous blood supply.
Claim 20
Independent Claim
20 words
A method according to any preceding claim, wherein the frequency is in the
range of about 10 kHz to100 MHz.
Claim 21
Dependent Claim
20 words
A method according to claim 20 wherein the frequency is in the range of
about 10 kHz to 500 kHz.
Claim 22
Dependent Claim
20 words
A method according to claim 21, wherein the frequency is in the range of
about 10 kHz to 100 kHz.
Claim 23
Dependent Claim
12 words
A method according to claim 22, wherein the frequency is 20 kHz.
Claim 24
Independent Claim
27 words
A method according to any one of claims 4 to 23, wherein the microcapsules
have a diameter in the range about 10 µm to about 5 µm.
Claim 25
Dependent Claim
18 words
A method according to claim 24, wherein the microcapsules range in diameter
between about 10 to 100 µm.
Claim 26
Dependent Claim
18 words
A method according to claim 25, wherein µthe microcapsules range in
diameter between about 20 to 50 µm.
Claim 27
Dependent Claim
18 words
A method according to claim 26, wherein the microcapsules range in diameter
between about 30 to 40 µm.
Claim 28
Independent Claim
33 words
A method according to any one of claims 5 to 27, wherein the density of the
microcapsules is sufficiently low to allow the microcapsules to be carried by
the bloodstream in a patient.
Claim 29
Independent Claim
27 words
A method according to any one of claims 5 to 28, wherein the density of the
microcapsules is in the range 1 to 5 g/cm 3 .
Claim 30
Dependent Claim
22 words
A method according to claim 29, wherein the density of the microcapsules is
in the range 1.8 to 3 g/cm 3 .
Claim 31
Dependent Claim
22 words
A method according to claim 30, wherein the density of the microcapsules is
in the range 1.8 to 2.2 g/cm 3 .
Claim 32
Dependent Claim
17 words
A method according to claim 31, wherein the density of the microcapsules is
2 g/cm 3 .
Claim 33
Independent Claim
29 words
A method according to any one of claims 3 to 32, wherein the magnetic
material used is mixed in a biocompatible liquid emulsion prior to delivery into
a patient.
Claim 34
Independent Claim
30 words
A method according to any one of claims 3 to 33, wherein an ionizing radiation
is applied to the locus of the diseased tissue in conjunction with the magnetic
field.
Claim 35
Dependent Claim
18 words
A method according to claim 34 wherein the radiation is delivered by
microcapsules which contain a radioactive compound.
Claim 36
Independent Claim
25 words
A method according to any one of claims 4 to 35, wherein the rate of tumour
tissue heating is greater than 60 mW/cm 3 .
Claim 37
Dependent Claim
20 words
A method according to claim 36 wherein the rate of tumour tissue heating is
is greater than 80 mW/cm 3
Claim 38
Dependent Claim
21 words
A method according to claim 36 wherein the rate of tumour tissue heating is
is greater than 100 mW/cm 3 .
Claim 39
Independent Claim
23 words
A method according to any preceding claim, wherein the magnetic materials
are bound together using a copolymer of (R)-3-hydroxybutyric acid and (R)-3-hydroxyvaleric
acid.
Claim 40
Independent Claim
38 words
A method according to any one of claims 3 to 39, wherein the magnetic
materials are delivered to the diseased tissue by one of the administration
methods selected from the group consisting of: intratumoral, peritumoral or
intravascular administrations.
Claim 41
Dependent Claim
46 words
A magnetic material, having a magnetic heating efficiency of at least 4.5 x 10 -8 J.m./A.g when rotational magnetic field conditions are equal or less than about
5 x 10 8 A/m.s, for use in treating biological material by generating hysteresis
heat in the biological material.
Claim 42
Dependent Claim
68 words
A magnetic material as claimed in claim 41 and an apparatus for generating
a magnetic field with a frequency of greater than about 10 kHz and a field
strength selected such that the product of field strength, frequency and the
radius of the exposed region is less than about 7.5 x 10 7 A/s for use in treating
biological material by generating hysteresis heat in the biological material.
References Cited (Backward Citations)
No citation records indexed.
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