EP0636378A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Absorbable composite materials for use in the treatment of periodontal disease
Assignee: Ethicon Inc
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Filing: 1994-07-27
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Granted: —
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Expires: 2014-07-27
Abstract
Abstract Absorbable composite materials are described that comprise a collagen matrix reinforced with a layer of a bioabsorbable polymer. A chemotherapeutic agent is dispersed in the composite material. The layer of bioabsorbable polymer is preferably a woven, nonwoven or knitted mesh layer of a synthetic bioabsorbable polymer such as polylactic/polyglycolic acid copolymer, or oxidised regenerated cellulose. The chemotherapeutic agent may be an antibiotic, an anaesthetic, an antiseptic or an anti-inflammatory. Strips of the composite material are inserted into the periodontal pocket, where they are retained in place and provide effective sustained release of the chemotherapeutic agent over an extended period.
Inventors
- 👤 Wilson Harvey
- 👤 Carla A. Haynes
- 👤 Nicholas D. Light
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 14:32
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61L27/00; A61L27/40; A61L27/44; A61L27/48; A61L27/50; A61L31/12; A61L31/125; A61L31/129; A61P; A61P1/00; A61P31/00; A61P31/04; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2210/00; A61F2210/0004
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
30 words
A composite material for use in the treatment of periodontal disease, comprising a collagen matrix reinforced with a layer of a bioabsorbable polymer and having a chemotherapeutic agent dispersed therein.
Claim 2
Dependent Claim
14 words
A composite material according to claim 1 wherein the collagen matrix comprises insoluble collagen.
Claim 3
Dependent Claim
27 words
A composite material according to claim 1 or 2 wherein the layer of a bioabsorbable polymer comprises a woven, nonwoven or knitted mesh of the bioabsorbable polymer.
Claim 4
Dependent Claim
21 words
A composite material according to any preceding claim wherein the bioabsorbable polymer is a synthetic bioabsorbable polymer or a modified cellulose.
Claim 5
Dependent Claim
24 words
A composite material according to claim 4 wherein the bioabsorbable polymer comprises a copolymer of lactic acid and glycolic acid or oxidised regenerated cellulose.
Claim 6
Dependent Claim
22 words
A composite material according to any preceding claim wherein the chemotherapeutic agent comprises an antibiotic, an anaesthetic, an antiseptic or an anti-inflammatory.
Claim 7
Dependent Claim
31 words
A composite material according to any preceding claim wherein the chemotherapeutic agent is present in an amount of 0.01% to 10% by weight, based on the weight of the composite material.
Claim 8
Dependent Claim
31 words
A composite material according to claim 7 wherein the chemotherapeutic agent is present in an amount of from 0.1% to 5% by weight, based on the weight of the composite material.
Claim 9
Dependent Claim
33 words
A composite material according to any preceding claim wherein the matrix further comprises an anionic bioabsorbable polymer in an amount up to 10% by weight, based on the weight of the composite material.
Claim 10
Dependent Claim
15 words
A composite material according to any preceding claim wherein the matrix further comprises a plasticiser.
Claim 11
Dependent Claim
14 words
A composite material according to claim 10, wherein the plasticiser is a polyhydric alcohol.
Claim 12
Dependent Claim
18 words
A composite material according to any preceding claim further comprising an oil phase dispersed in the collagen matrix.
Claim 13
Dependent Claim
30 words
A composite material according to claim 12 wherein the oil is present in an amount of from 1% to 20% by weight, based on the weight of the composite material.
Claim 14
Dependent Claim
25 words
A composite material according to any preceding claim in the form of a sheet or strip having a thickness of from 0.5 to 2.0 mm.
Claim 15
Dependent Claim
12 words
A composite material substantially as hereinbefore described with reference to the examples.
Claim 16
Dependent Claim
22 words
Use of a composite material according to any preceding claim in the preparation of a medicament for the treatment of periodontal disease.
References Cited (Backward Citations)
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