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EP0636377A1
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EP
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Composite surgical material
Assignee: Ethicon Inc
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Filing: 1994-07-27
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Granted: —
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Expires: 2014-07-27
Abstract
Abstract A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidised regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.
Inventors
- 👤 Wilson Harvey
- 👤 Nicholas Light
- 👤 Carla Haynes
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:35
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/48; A61L27/50; A61L31/00; A61L31/12; A61L31/125; A61L31/129
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
26 words
A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material and having oil droplets dispersed in the collagen matrix.
Claim 2
Dependent Claim
24 words
A composite surgical material according to claim 1, wherein the oil droplets comprise from 1% to 75% by weight of the composite surgical material.
Claim 3
Dependent Claim
26 words
A composite surgical material according to claim 1 or 2, wherein the oil droplets comprise from 5% to 50% by weight of the composite surgical material.
Claim 4
Dependent Claim
25 words
A composite surgical material according to any preceding claim, wherein the oil droplets comprise from 10% to 40% by weight of the composite surgical material.
Claim 5
Dependent Claim
25 words
A composite surgical material according to any preceding claim wherein the synthetic bioabsorbable material comprises a polymer or copolymer of lactic acid and/or glycolic acid.
Claim 6
Dependent Claim
18 words
A composite surgical material according to any preceding claim wherein the synthetic bioabsorbable material comprises oxidised regenerated cellulose.
Claim 7
Dependent Claim
25 words
A composite surgical material according to any preceding claim wherein the layer of synthetic bioabsorbable material is a knitted, woven or non-woven mesh or web.
Claim 8
Dependent Claim
18 words
A composite surgical material according to any preceding claim, further comprising an antibiotic, an antiseptic or an anti-inflammatory.
Claim 9
Dependent Claim
19 words
A composite surgical material according to any preceding claim further comprising a growth factor, a cytokine or a glycosaminoglycan.
Claim 10
Dependent Claim
20 words
A composite surgical material according to any preceding claim which is in the form of a sheet or a tube.
Claim 11
Dependent Claim
20 words
Use of a composite surgical material according to any preceding claim for the preparation of a surgical graft or prosthesis.
Claim 12
Dependent Claim
52 words
A process to prepare a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.
Claim 13
Dependent Claim
33 words
A process according to claim 12 wherein the step of providing a dispersion of collagen in an oil-in-water emulsion comprises mixing the collagen and the oil with water followed by emulsifying the oil.
Claim 14
Dependent Claim
15 words
A process according to claim 12 or 13, wherein the collagen comprises insoluble fibrous collagen.
Claim 15
Dependent Claim
26 words
A process according to claim 12, 13 or 14, wherein the weight ratio of collagen to oil in the said emulsion is from 10:1 to 1:10.
Claim 16
Dependent Claim
23 words
A process according to claim 15, wherein the weight ratio of collagen to oil in the said emulsion is from 2:1 to 1:5.
Claim 17
Dependent Claim
23 words
A process according to claim 16, wherein the weight ratio of collagen to oil in the said emulsion is from 1:1 to 1:3.
Claim 18
Dependent Claim
26 words
A process according to any of claims 12 to 17, wherein the synthetic bioabsorbable material comprises a polymer or copolymer of lactic acid and/or glycolic acid.
Claim 19
Dependent Claim
19 words
A process according to any of claims 12 to 18, wherein the synthetic bioabsorbable material comprises oxidised regenerated cellulose.
Claim 20
Dependent Claim
25 words
A process according to any of claims 12 to 19, wherein the layer of synthetic bioabsorbable is a knitted, woven or non-woven mesh or web.
Claim 21
Dependent Claim
29 words
A process according to any of claims 12 to 20, further comprising the step of dispersing an antibiotic, an antiseptic or an anti-inflammatory compound in the said oil-in-water emulsion.
Claim 22
Dependent Claim
30 words
A process according to any of claims 12 to 21, further comprising the step of dispersing a growth factor, a cytokine and/or a glycosamino glycan in the said oil-in-water emulsion.
References Cited (Backward Citations)
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