Use of rapamycin for the manufacture of a medicament for the treatment of immunoinflammatory diseases

Abstract

Abstract This invention provides a method of treating immunoinflammatory skin or bowel disease in a mammal in need thereof which comprises administering an antiimmunoinflammatory amount of rapamycin, alone or in combination with cyclosporin A, orally, parenterally, intranasally, intrabronchially, topically, transdermally, or rectally. As such, rapamycin, alone or in combination with cyclosporin A, is useful in treating skin deseases such as psoriasis, atopic dermatitis, contact dermatitis, exczematous dermatitis, seborrheic dermatitis, Lichen planus, Pemphigus, bulus pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythmas, cutaneous eosinphilias, and the like; and bowel disease such as inflammatory bowel disease.

Inventors

• 👤 Craig Eugene Caufield
• 👤 John Henry Musser
• 👤 Surendra Nath Sehgal

Bibliographic Details