Patent EP0511499A2 successfully refreshed from Google Patents.
EP0511499A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Method and catheter for controlled intravascular drug delivery
Assignee: Abbott Cardiovascular Systems Inc
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Filing: 1992-03-27
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Granted: —
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Expires: 2012-03-27
Abstract
Abstract A vascular perfusion catheter includes a catheter body having a macroporous matrix forming at least a portion of its distal end. Blood flow is measured in situ by a Doppler mechanism operably coupled to the catheter body. A solution carrying a desired therapeutic agent may be introduced through the catheter and released through the macroporous matrix until a preselected blood flow is observed.
Inventors
- 👤 Hanson S. Gifford
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 19:23
CPC Classifications
A; A61; A61B; A61B8/00; A61B8/06; A61B8/12; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6957; A61M; A61M25/00; A61M25/0043
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
93 words
A vascular perfusion catheter comprising: an inner flexible tubular member having a proximal end, a distal end, and a central lumen extending between the proximal and distal ends; and an outer flexible tubular member disposed coaxially about the inner flexible tubular member and sealed thereto near the distal end to define an annular lumen having a closed distal end, wherein at least a portion of the outer flexible tubular member near the distal end is formed from a macroporous matrix material which will allow the controlled diffusion of macromolecules from the annular lumen.
Claim 2
Dependent Claim
93 words
A vascular perfusion catheter comprising: an inner flexible tubular member having a proximal end, a distal end, and a central lumen extending between the proximal and distal ends; and an outer flexible tubular member disposed coaxially about the inner flexible tubular member and sealed thereto near the distal end to define an annular lumen having a closed distal end, wherein at least a portion of the outer flexible tubular member near the distal end is formed from a macroporous matrix material which will allow the controlled diffusion of macromolecules from the annular lumen.
Claim 3
Dependent Claim
23 words
A vascular catheter as in claim 1, wherein the macroporous matrix is disposed at or near the distal end of the catheter body.
Claim 4
Dependent Claim
25 words
A vascular catheter as in claim 2, wherein the macroporous matrix extends over a length in the range from about 2 cm to 50 cm.
Claim 5
Dependent Claim
19 words
A catheter as in claim 1, wherein the macroporous matrix has a molecular weight cutoff above about 10,000 daltons.
Claim 6
Dependent Claim
14 words
A catheter as in claim 1, wherein the macroporous matrix comprises a woven fabric.
Claim 7
Dependent Claim
14 words
A catheter as in claim 1, wherein the macroporous matrix comprises a non-woven fabric.
Claim 8
Dependent Claim
35 words
A catheter us in claim 1, wherein the macroporous matrix comprises a fabric having fibers composed of a material selected from the group consisting of polyethylene, polypropylene, polyester, nylon, polytetrafluoroethylene, polycarbonate, polystyrene, cellulose, and polyacetonitrile.
Claim 9
Dependent Claim
16 words
A catheter as in claim 7, wherein the macroporous matrix comprises a woven polyethylene terephthalate fabric.
Claim 10
Dependent Claim
15 words
A catheter as in claim 1, wherein the macroporous matrix comprises an organic polymer membrane.
Claim 11
Dependent Claim
29 words
A catheter as in claim 1, further comprising means for partitioning the annular lumen into at least two isolated regions and means for separately delivering fluid to each region.
Claim 12
Dependent Claim
28 words
A catheter as in claim 10, wherein the means for partitioning comprises an annular barrier extending between the inner flexible tubular member and the outer flexible tubular member.
Claim 13
Dependent Claim
32 words
A catheter as in claim 11, wherein the means for separately delivering fluids comprises at least two isolated lumens extending from the proximal end of the inner tubular member to the region.
Claim 14
Dependent Claim
109 words
A vascular perfusion catheter comprising: an inner flexible tubular member having a proximal end, a distal end, and a central lumen extending between the proximal and distal ends; an outer flexible tubular member disposed coaxially about the inner flexible tubular member and sealed thereto near the distal end to define an annular lumen having a closed distal end, wherein at least a portion of the outer flexible tubular member near the distal end is formed from a macroporous matrix material which will allow the controlled diffusion of macromolecules from the annular lumen; and at least one Doppler crystal attached to the catheter for measuring blood flow past the catheter.
Claim 15
Dependent Claim
109 words
A vascular perfusion catheter comprising: an inner flexible tubular member having a proximal end, a distal end, and a central lumen extending between the proximal and distal ends; an outer flexible tubular member disposed coaxially about the inner flexible tubular member and sealed thereto near the distal end to define an annular lumen having a closed distal end, wherein at least a portion of the outer flexible tubular member near the distal end is formed from a macroporous matrix material which will allow the controlled diffusion of macromolecules from the annular lumen; and at least one Doppler crystal attached to the catheter for measuring blood flow past the catheter.
References Cited (Backward Citations)
No citation records indexed.
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