Fibrinogen receptor antagonists

Claim 1

A fibrinogen receptor antagonist of Formula I: wherein: X is Y is R and R¹ are independently hydrogen, aryl, wherein aryl is defined as a five or six membered mono or polycyclic aromatic ring system containing 0, 1, 2, 3, or 4 heteroatoms selected from nitrogen, oxygen and sulfur, either unsubstituted or substituted, with one or more groups selected from hydroxyl, halogen, cyano, trifluromethyl, C₁₋₃alkoxy, C₁₋₅ alkylcarbonyloxy, C₁₋₅ alkoxycarbonyl, C₁₋₅ alkyl, aminoC₁₋₅alkyl, hydroxycarbonylC₀₋₅ alkyl, or hydroxycarbonylC₁₋₅ alkoxy, C 0-6alkyl, either unsubstituted or substituted, with one or more groups selected from halogen, hydroxyl, C₁₋₅ alkylcarbonylamino, arylC₁₋₅alkylcarbonylamino, aryloxy, C₁₋₁₀ alkoxy, C₁₋₅ alkoxycarbonyl, C₀₋₅ alkyolaminocarbonyl, C₁₋₅ alkylcarbonyloxy, C₃₋₈ cycloalkyl, aryl, oxo, amino, C₁₋₆ alkyl, C₁₋₃ alkylamino, aminoC₁₋₃ alkyl, aryl C₀₋₅alkylaminocarbonyl, ethylene, phenylC₁₋₃ alkylamino, aminocarbonylC₀₋₄ alkyl, or hydroxycarbonyl C₀₋₅ alkyl; provided that the carbon atom to which R and R¹ is attached bears only one heteroatom; R², R³ and R⁴ are independently hydrogen, C₁₋₁₂ alkyl, unsubstituted or substituted, with one or more C₁₋₆ alkyl groups, or arylC₀₋₄alkyl, or cyano, provided that when R² and R³ are independently cyano, R⁵ is hydrogen, C₁₋₆ alkyl, either unsubstituted or substituted, with one or more groups selected from C₁₋₆ alkyl, C₁₋₅ alkoxy, C₁₋₅ alkoxycarbonyl, hydroxycarbonylC₀₋₄ alkyl, aryl, aminoC₁₋₄alkyl, arylaminocarbonylC₀₋₄alkyl, C₁₋₄ alkyl sulfonyl, phenylC₀₋₄ alkylsulfonyl, hydroxyl, or amino, hydroxycarbonyl, hydroxy or amino, provided that when R⁵ is hydroxy or amino, R⁵ is not attached to a carbon bearing a heteroatom; R⁶ is hydrogen, C₁₋₁₂ alkyl, unsubstituted or substituted, with one or more C₁₋₆ alkyl groups, arylC₀₋₃ alkyl, C₁₋₄ alkyloxycarbonyl, arylC₁₋₄ alkyloxycarbonyl, C₁₋₄ alkylaminocarbonyl, arylC₁₋₄ alkylaminocarbonyl, C₂₋₅ alkoxy, oxycarbonylC₂₋₅ alkyl, aminocarbonylC₂₋₅ alkyl; R⁷ is hydrogen; C₁₋₁₂ alkyl, unsubstituted or substituted, with one or more C₁₋₆ alkyl groups, C₃₋₇ cycloalkyl hydroxyl, hydroxycarbonyl, aminocarbonyl, oxo, aryl; aryl; or C₃₋₇ cycloalkyl; m is 1-10; n is 0-9; q is 0-2; p is 1-6; Z is 0, N, S; or the pharmaceutically acceptable salts thereof, or optical isomer thereof.