Patent US3701977A successfully refreshed from Google Patents.
Patent EP0459148A2 successfully refreshed from Google Patents.
EP0459148A2
Expired / Lapsed
EP
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Dry eye treatment composition
Assignee: Ocular Research of Boston Inc
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Filing: 1991-04-25
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Granted: —
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Expires: 2011-04-25
Abstract
Abstract A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying an admixture of a charged phospholipid and a non-polar oil over the eye, preferably in the form of a meta-stable oil in water emulsion in a dosage not exceeding 100 microliters.
Inventors
- 👤 Thomas Glonek
- 👤 Donald R. Korb
- 👤 Jack V. Greiner
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 18:34
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02; A61P27/04
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
19 words
An artificial tear film over an ocular surface comprising an aqueous layer coated with a film of an oil.
Claim 2
Dependent Claim
25 words
The tear film of claim 1 with a layer of a complex phospholipid having a net charge between the aqueous layer and the oil film.
Claim 3
Dependent Claim
13 words
The tear film of claim 1 where the oil is a non-polar oil.
Claim 4
Dependent Claim
24 words
The tear film of claim 1 where the oil available to form the oil layer does not exceed a volume of about 25 microliters.
Claim 5
Dependent Claim
16 words
The tear film of claim 4 where the volume ranges between about 1 and 10 microliters.
Claim 6
Dependent Claim
12 words
The tear film of claim 1 where the oil is a hydrocarbon.
Claim 7
Dependent Claim
14 words
The tear film of claim 2 where the phospholipid carries a net negative charge.
Claim 8
Dependent Claim
36 words
The tear film of claim 7 where the phospholipid layer has polar groups extending towards the aqueous layer of the tear film and non-polar groups extending away from the aqueous layer and into the oil layer.
Claim 9
Dependent Claim
11 words
The tear film of claim 7 where the phospholipid is phosphatidylglycerol.
Claim 10
Dependent Claim
11 words
The tear film of claim 1 having a contact lens thereon.
Claim 11
Independent Claim
38 words
A method for reducing evaporation from an aqueous tear film over the surface of an eye, said method comprising applying an admixture of a complex phospholipid having a net charge and an oil over an aqueous tear film.
Claim 12
Dependent Claim
12 words
The method of claim 11 where the oil is a non-polar oil.
Claim 13
Dependent Claim
21 words
The method of claim 11 where the total dose of the admixture added to the eye does not exceed 100 microliters.
Claim 14
Dependent Claim
15 words
The method of claim 13 where the dose varies between about 25 and 50 microliters.
Claim 15
Dependent Claim
23 words
The method of claim 11 where the amount of oil available to form a film over the eye does not exceed 10 microliters.
Claim 16
Dependent Claim
10 words
The method of claim 11 where the phospholipid is phosphatidylglycerol.
Claim 17
Dependent Claim
12 words
The method of claim 18 where the oil is a hydrocarbon oil.
Claim 18
Dependent Claim
20 words
The method of claim 11 where the admixture is applied to the eye in the form of a meta-stable emulsion.
Claim 19
Dependent Claim
40 words
The method of claim 18 where the phospholipid is present in the emulsion in a concentration ranging between 0.1 and 7.0 percent by weight and the oil is present in an amount ranging between 0.2 and 12.5 percent by weight.
Claim 20
Dependent Claim
30 words
The method of claim 29 where the emulsion contains a non toxic, component compatible, non-stinging surfactant that is a member selected from the group of polyoxyether esters and polyoxyether acids.
Claim 21
Dependent Claim
11 words
The method of claim 18 where the emulsion contains a medicant.
Claim 22
Dependent Claim
28 words
The method of claim 18 where the emulsion is applied to the eye by applying the emulsion to a contact lense and inserting the lens in the eye.
Claim 23
Independent Claim
30 words
A method for reducing evaporation of an aqueous tear film from the surface of an eye, said method comprising forming an artificial film of an oil over said tear film.
Claim 24
Dependent Claim
13 words
The method of claim 23 where the oil is a non-polar hydrocarbon oil.
Claim 25
Dependent Claim
12 words
The method of claim 23 where the oil is a mineral oil.
Claim 26
Dependent Claim
20 words
The method of claim 23 where the volume of oil available to form the film does not exceed 25 microliters.
Claim 27
Dependent Claim
14 words
The method of claim 26 where the volume ranges between 1 and 10 microliters.
Claim 28
Dependent Claim
13 words
The method of claim 26 where the oil is administered from a microdropper.
Claim 29
Dependent Claim
25 words
The method of claim 23 where a phospholipid having a net negative charge is added to the eye prior to the addition of the oil.
Claim 30
Dependent Claim
25 words
The method of claim 39 including a step of insertion of a contact lense into the eye following application of the oil to the eye.
Claim 31
Dependent Claim
22 words
An ocular treatment composition comprising an aqueous oil in water emulsion containing a complex phospholipid having a net charge and an oil.
Claim 32
Dependent Claim
12 words
The composition of claim 31 in the form of a meta-stable emulsion.
Claim 33
Dependent Claim
21 words
The composition of claim 31 where the phospholipid carries a net negative charge and the oil is an essentially non-polar oil.
Claim 34
Dependent Claim
30 words
The composition of claim 33 where the phospholipid component and the essentially non-polar oil are each present in the emulsion in a concentration of at least 0.01 percent by weight.
Claim 35
Dependent Claim
41 words
The composition of claim 34 where the phospholipid component is present in the emulsion in a concentration ranging between 0.1 and 7.0 percent by weight and the oil is present in an amount ranging between 0.2 and 12.5 percent by weight.
Claim 36
Dependent Claim
36 words
The composition of claim 31 where the oil is present in the emulsion in a concentration sufficient to provide a volume of oil not exceeding about 10 microliters for formation of a film over the eye.
Claim 37
Dependent Claim
17 words
The composition of claim 31 where the emulsion contains a non toxic, component compatible, non stinging surfactant.
Claim 38
Dependent Claim
14 words
The composition of claim 37 where the surfactant is a polyether ester or acid.
Claim 39
Dependent Claim
11 words
The composition of claim 37 where the emulsion contains a medicant.
Claim 40
Dependent Claim
10 words
The composition of claim 39 where the phospholipid is phosphatidylglycerol.
References Cited (Backward Citations)
No citation records indexed.
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