Patent EP0455463A1 successfully refreshed from Google Patents.
EP0455463A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Packaging for microdoses of powdered medicament for inhalation
Assignee: Riker Laboratories Inc
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Filing: 1991-04-30
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Granted: —
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Expires: 2011-04-30
Abstract
Abstract A sheet material comprising discrete depressions which are at least partially filled with micronized medicament and which are useful as or in a drug delivery device. This sheet material is useful in devices which provide for aerosolization of the medicament, for delivery to a patient by inhalation.
Inventors
- 👤 David J. C/O Minnesota Mining And Velasquez
- 👤 Peter D. C/O Minnesota Mining And Hodson
- 👤 Clyde D. C/O Minnesota Mining And Calhoun
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 17:01
CPC Classifications
A; A61; A61M; A61M15/00; A61K; A61K9/00; A61K9/0012; A61K9/007; A61K9/0073; A61K9/0075; A61J; A61J3/00; A61M15/0028; A61M15/0045; A61M15/0046; A61M15/0051; A61M15/02; B; B29; B29C; B29C65/00; B29C65/02; B29C65/18; B29C66/00; B29C66/80; B29C66/81; B29C66/814; B29C66/8145; B29C66/81457; B29C66/83; B29C66/834; B29C66/8341; B29C66/83411; B29C66/83413; B29K; B29K2821/00; B29L; B29L2031/00; B29L2031/712; B29L2031/7162; B29L2031/7164; B29L2031/753
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
84 words
A flexible sheet material comprising a plurality of discrete depressions in at least one surface thereof, each of said depressions having a depth of about 5 to 500 µm, but less than the thickness of said sheet material, and an opening at the surface of said sheet of about 10 to 500 µm across, a substantial number of said depressions being at least partially filled with micronized medicament, and the area of said surface between said depressions being substantially free of said micronized medicament.
Claim 2
Dependent Claim
18 words
A flexible sheet material according to Claim 1, comprising a polymeric layer in which said depressions are made.
Claim 3
Dependent Claim
32 words
A flexible sheet material according to Claim 2, wherein said polymeric layer comprises a polymer selected from the group consisting of a polyethylene, a polypropylene, a polyester, a polytetrafluoroethylene and a cellulose.
Claim 4
Dependent Claim
23 words
A flexible sheet material according to Claim 2, wherein said polymeric layer is laminated or melt-bonded to or extruded onto a support layer.
Claim 5
Dependent Claim
29 words
A flexible sheet material according to Claim 4, wherein said support layer is selected from the group consisting of a non-woven material, a woven material and a metallized layer.
Claim 6
Dependent Claim
16 words
A flexible sheet material according to Claim 5, wherein said support layer is a "kraft" paper.
Claim 7
Dependent Claim
38 words
A flexible sheet material according to Claim 1, wherein said medicament is selected from the group consisting of an antiallergic, a bronchodilator, an antihistamine, a steroid and a mixture of two or more of any of the foregoing.
Claim 8
Dependent Claim
49 words
A flexible sheet material according to Claim 7, wherein said medicament is selected from the group consisting of albuterol, albuterol sulfate, pirbuterol acetate, pirbuterol hydrochloride, beclomethasone dipropionate, disodium cromoglycate, isoproterenol hydrochloride, isoproterenol sulfate, phenylephrine bitartrate, phenylephrine hydrochloride, epinepherine bitartrate and a mixture of two or more of the foregoing.
Claim 9
Dependent Claim
26 words
A flexible sheet material according to Claim 1, wherein a substantial number of said recesses contain a physiologically acceptable inert excipient in addition to said medicament.
Claim 10
Dependent Claim
37 words
A flexible sheet material according to Claim 1, wherein said depressions have a depth of about 5 to 150 µm and an opening at the surface of said sheet material of about 50 to 200 µm across.
Claim 11
Dependent Claim
22 words
A flexible sheet material according to Claim 1, wherein said depressions number about 500 to 15,000 per cm² of said sheet material.
Claim 12
Dependent Claim
18 words
A flexible sheet material according to Claim 1, wherein said depressions are configured in a substantially regular array.
Claim 13
Dependent Claim
17 words
A flexible sheet material according to Claim 1, having a substantially uniform depression volume per unit area.
Claim 14
Dependent Claim
25 words
A flexible sheet material according to Claim 1, wherein said depressions are of a configuration selected from truncated cones, truncated pyramids, partial hemispheres and tetrahedrons.
Claim 15
Dependent Claim
22 words
A flexible sheet material according to Claim 1, wherein a substantial number of said depressions are filled to a controlled depth thereof.
Claim 16
Dependent Claim
31 words
A flexible sheet material according to Claim 1, wherein a substantial number of said depressions are substantially filled with a known volume of medicament per unit area of said sheet material.
Claim 17
Dependent Claim
33 words
A flexible sheet material according to Claim 16, wherein an area of about 0.1 to 25 cm² of said sheet material corresponds to a single dose of said medicament when administered by inhalation.
Claim 18
Dependent Claim
14 words
A flexible sheet material according to Claim 1 in the form of a tape.
Claim 19
Dependent Claim
22 words
An article comprising a flexible sheet material according to Claim 16 wound on a spool or in the form of a roll.
Claim 20
Dependent Claim
27 words
A flexible sheet material according to Claim 1, wherein said medicament may be aerosolized from said depressions in a substantially deagglomerated state for inhalation by a patient.
Claim 21
Dependent Claim
30 words
A cassette comprising a housing, a sheet material according to Claim 1 in the form of a rolled tape, and a tape advance control mechanism to provide uniform tape advance.
Claim 22
Dependent Claim
66 words
A flexible sheet material according to Claim 1, wherein said depressions are formed by an imprinting process comprising pressing the sheet material against a master surface bearing protuberances of appropriate size and shape to form the depressions, said process optionally involving heating of said sheet material to a temperature less than about the melting point of any polymeric layer in which said depressions are being made.
References Cited (Backward Citations)
WO1990013328A1
Cited
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