Peptide derivatives with amphiphatic properties, intermediates thereof and liposomes and films comprising said derivatives

Abstract

Abstract A peptide derivative amphiphatic compound or N-terminal salt thereof represented by formula (I): wherein R¹ and R² each represents a straight-chain or branched alkyl or acyl group having 8 to 24 carbon atoms optionally having a substituent or an unsaturated group; X represents -O-or -NH-; R 3n and R 3(n+1) each represents an α-amino acid side chain; n is an integer of from 0 to 5; the compound may be a racemic compound or an optically active compound when the compound has an asymmetric carbon atom; and the N-terminal salt of the compound optionally forms with an acid component; an intermediate thereof, a liposome comprising said peptide derivative amphiphatic compound and a film consisting of a monolayer or multilayers comprising the peptide derivative amphiphatic compound are disclosed.

Inventors

• 👤 Hiroshi Kitaguchi
• 👤 Ryoichi Nemori

Bibliographic Details