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EP0451745A1 Expired / Lapsed EP ⏱️ 0.0 years remaining

Device for the administration of powdered medicinal substances

Assignee: Chiesi Farmaceutici SpA
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Filing: 1991-04-08
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Granted: —
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Expires: 2011-04-08
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Abstract

Abstract This invention relates to a new inhaler for the local administration of powdered drugs to the respiratory tract. The apparatus consists of a nozzle (1) and a main body (2) which itself defines a storage chamber (8) for the medicinal substance, a dosing means (14,17) which supplies precisely measured doses of the drug and a dispensing system (18,19) which pours the dose of the drug delivered into a collecting chamber (24). The cavity (4) of the nozzle (1) communicates with the collecting chamber (24) through a central channel (6) designed to reduce air flow resistance as much as possible. Lateral holes (23) provided in the body (2) of the inhaler allow for the passage of air from the outside. Upon inhalation, a negative pressure is created in the chamber (24) in which the dose of powder delivered is collected, drawing an air inflow from the outside. The air flow is mixed with the medicinal substance particles and through the central channel (6), enters the cavity (4) of the nozzle (1) from where it is directly inhaled.

Inventors

  • 👤 Paolo Chiesi
  • 👤 Paolo Ventura
  • 👤 Isabella Panza

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-11-05 13:18
CPC Classifications
A; A61; A61M; A61M11/00; A61M11/001; A61M11/002; A61M37/00; A61M15/00; A61M15/0065; A61M15/0066; A61M2202/00; A61M2202/06; A61M2202/064

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 181 words
Device for the administration of powdered medicinal substances, consisting of a nozzle (1) having an aperture (3) and a main body (2) which itself comprises a circular storage chamber (8) for the powder, a dosing means provided on the bottom of this chamber, consisting of a dosing hole (14) and a rotating dosing diaphragm (17), a dispensing system consisting of a disc (18) provided with a dispensing hole (19) and a ventilation chamber (24) adapted to collect successive doses of the drug, this device being characterised in that the aperture of the nozzle is in direct communication with the ventilation chamber by means of a circular channel having a diameter of between 3 and 5 mm and a height of between 2.5 and 4 cm and disposed axially with respect to the body (2), and that the said ventilation chamber is itself in communication with the outside by means of a series of slots (23) provided in the external body of the device and connected together to form a circular space between the said external body and the main body (2).
Claim 2
Dependent Claim 80 words
Device according to claim 1, characterised in that the distribution and dispensing of precise doses of the drug are controlled by relative rotation of the nozzle and the main body, itself integral with the storage chamber for the powder, in such a manner that a first rotation through 180 o loads the powdered medicinal substance into the dosing hole -18- (14) and a second rotation through 180 o in the opposite direction pours the dose delivered into the ventilation chamber.
Claim 3
Dependent Claim 85 words
Device according to claims 1 and 2, characterised in that after the first rotation through 180 o , the means is in a closed position defined by the engagement of one of the teeth of the dispensing disc (18) and the projection (20) provided on the base of the central body and that a second closed position is defined in an analogous manner, after the second rotation through 180 o in the opposite direction, by the engagement of the other tooth in the abovementioned projection.
Claim 4
Dependent Claim 36 words
Device according to claims 1 and 2, characterised in that the internal circular channel (6) has a contraction adapted to increase the turbulence of the air flow and to further promote the disaggregation of the powder.
Claim 5
Dependent Claim 27 words
Device according to claims 1, 2 and 4, characterised in that the contraction of the internal circular channel is defined by the presence of helical blades (30).
Claim 6
Dependent Claim 35 words
Device according to claims 1, 2 and 4, characterised in that the contraction of the internal circular channel is defined by the presence of a tapering zone (31) in the form of a Venturi tube.
Claim 7
Dependent Claim 90 words
Device according to claims 1 to 6, characterised in that it is activated by an act of inhalation by the patient, creating a negative pressure in the interior of the chamber (24) into which the dose of the medicinal substance is dispensed and draws an inflow of air from the outside, through the slots (23), the said air flow entering the collecting chamber for the powder, mixing with the said powder and carrying it through the central channel to the cavity of the nozzle from where it is directly inhaled.
Claim 8
Dependent Claim 26 words
Device according to claims 1 to 7 for the administration of drugs in the form of micronised powder for inhalation for the treatment of bronchopulmonary disorders.

References Cited (Backward Citations)

GB2041763A Cited
EP0147755A2 Cited

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