Application system for drug containing microemulsions

Claim 1

A device, in particular a bandage strip, for a dermal administration of a drug to a patient, with a reservoir (5) for storing and delivering the drug onto the skin of the patient and with a carrier element for carrying the reservoir, whereby this carrier element is provided with a skin-compatible adhesive layer (3), by which the device is adhered to the skin of the patient in the application state, and with a peelable protective liner (4) covering the adhesive layer (3) and the reservoir (5) at the side of delivery in the state of storage, wherein the carrier element is formed by a relatively flat foamed material piece (2) with closed pores and is traversed by punched out holes extending between the opposite surfaces and forming the reservoir (5) in which a highly viscous medium (paste or ointment) is placed as the drug preparation to be slowly diffused through the skin during the application, and wherein a polymer film (1) coated with an adhesive (3a, 7, 8) is removably placed onto the surface of the foamed material piece (2) opposite the side carrying the skin-compatible adhesive layer (3) thereby covering the inlet side of the reservoir (5), and wherein the peelable protective liner (4) consists of an adhesion releasing protective film which prevents a lateral migration during the storage of the device.

Claim 3

A device according to one of the Claims 1 or 2, wherein the protective film and the polymer film are each provided with a pull-off strap (6) extending beyond the surface of the foamed material piece.

Claim 4

A device according to one of the claims 1 to 3, wherein the polymer film (1) is non-transparent and fastened to the foamed material piece (2) by means of two parallel adhesive strips (7,8) and aligned along the crosswise edges, whereby the adhesive strip (7) situated a distance away from the pull-off strap (6) of the polymer film (1) is formed by an adhesive with a high adhesive strength and the adhesive strip (8) adjacent to the pull-off strap (6) is formed by a repeatedly usable adhesive of a low adhesive strength.

Claim 5

A device according to one of the claims 1 to 4, wherein the polymer film (1) is transparent and micro-perforated.

Claim 6

A device according to one of the claims 1 to 5 wherein the protective film (4) is coated with a pattern of silicone of other adhesion releasing materials at the side facing the adhesive layer (3) in such a way, that a barrier is formed by the remaining non-coated protective film surface in conjunction with the adhesive layer (3) to prevent a lateral migration of the drug preparation into the skin-compatible adhesive layer.

Claim 7

A device according to one of the Claims 1 to 6, wherein the coated and non-coated partial areas and of the pattern on the surface of the peelable protective film (4) in contact with the adhesive layer (3) are varied in their sizes and/or in the ratio of their geometrical shapes according to the consistency of the drug preparation for optimizing the barrier effect of the uncoated partial areas and the peelability of the protective film.

Claim 8

A device according to one of the Claims 1 to 7, wherein the coated partial areas of the pattern are squares separated by non-coated stays.

Claim 9

A device according to one of the Claims 1 to 8, wherein the coated partial areas of the pattern have a circular, triangular, rectangular, elliptic or rhombic shape and the intermediary non-coated partial areas have a correspondingly geometric shape.

Claim 10

A device according to one of the Claims 1 to 9, wherein the coated partial form islands and the non-coated stays form a continuous barrier.

Claim 11

A device according to one of the Claims 1 to 10, wherein the skin-compatible adhesive consists of components, which prevent a penetration by the drug formulation.

Claim 12

A device, in particular a bandage strip, for a dermal administration of a drug to a patient, with a reservoir for storing and delivering the drug onto the skin of the patient and with a carrier element for carrying the reservoir, whereby this carrier element is provided with a skin-compatible adhesive layer (10), by which the device is adhered to the skin of the patient in the application state, and with a peelable protective film (16) (liner) covering the adhesive layer (10) and the reservoir at the side of delivery in the state of storage, wherein the carrier element is formed by a non-woven fleece tape (9) with an adhesive layer (10) attached to its underside and to which an element of an absorbent material (11) is adhesively attached forming the reservoir, and wherein a filling opening (12) is provided for at least one low-viscous solution of the drug formulation, whereby this filling opening (12) transverses the non-woven tape (9) and its adhesive layer (10) and forms a communicating connection to the element of an absorbent material (11) saturated with the low-viscous drug solution during the storage of the device, and wherein at the upper side of the non-woven fleece tape (9) a cover (15) is provided coated with a pressure-sensitive repeatedly usable adhesive layer (13) covering the filling opening (12) and wherein the peelable protective film (16) consists of an adhesion releasing protective film which prevents a lateral migration during the storage of the device.

Claim 14

A device according to any one of preceding claims 12-13 wherein an occlusive barrier layer (17) is attached onto the element (11) at the filling side, whereby the barrier layer (17) is firmly adhered with its side facing away from the element (11) to the adhesive layer (10) of the non-woven fleece tape (9) and is traversed by the filling opening (12) communicating with the element (11).

Claim 16

A device according to any one of preceding claims 12-15 wherein the low-viscous solution contains a drug.

Claim 17

A device according to any one of preceding claims 12-16 wherein the adhesive layer (10) of the non-woven fleece tape (9) is impermeable to moisture and is non-adsorbent.

Claim 18

A device according to any one of preceding claims 12-17 wherein the protective film (16) is coated with a pattern of silicone or other adhesion releasing material at the side facing the adhesion layer (10) in such a way that a barrier is formed by the remaining non-coated protective film surface in conjunction with the adhesive layer to prevent a lateral migration of the drug preparation into the skin-compatible adhesive layer (10).

Claim 19

A device according to any one of preceding claims 12-18 wherein the coated and non-coated partial areas and of the pattern on the surface of the peelable protective film in contact with the adhesive layer are varied in their sizes and/or in the ratio of their geometrical shapes according to the consistency of the drug preparation for optimizing the barrier effect of the uncoated partial areas and the peelability of the protective film.

Claim 23

A device according to any one of preceding claims 12-22 wherein the skin-compatible adhesive (10) consists of components which prevent penetration by the drug formulation.

Claim 24

A device, in particular a bandage strip for a dermal administration of a drug to a patient, with a reservoir (21) for storing and delivering the drug onto the skin of the patient and with a carrier element for carrying the reservoir, whereby this carrier element is provided with a skin-compatible adhesive layer (19) by which the device is adhered to the skin of the patient in the application state and with a peelable protective film (liner) (24) covering the adhesive layer (19) and the reservoir (21) at the side of delivery in the state of storage, wherein the carrier element is formed by a relatively flat foamed material (18) with closed pores, on which an adhesive layer (20) is applied to the surface opposite the side carrying the skin-compatible adhesive layer (19) and wherein the composite structure consisting of the adhesive layer (20) the foamed material (18) and the skin-compatible adhesive layer (19) is traversed by a punched out hole forming a reservoir (21) to be filled with an absorbent material (22) adsorptively containing a micro-emulsion of the drug formulation, and wherein a protective film (23) covering the punched out opening at the filling side is attached to the adhesive layer (20) thereby preventing a lateral migration of the drugs contained in the micro-emulsion adsorbed at the adsorbent material, and wherein the peelable protective film liner (24) attached to the skin-compatible adhesive layer (19) covers the punched out opening at the delivery side during the storage of the device and the peelable protective film (24) consists of an adhesion releasing protective film, which prevents a lateral migration during the storage of the device.

Claim 26

A device according to any one of preceding claims 24-25 wherein the protective film (24) is heat-sealed with the adhesive layer (20).

Claim 27

A device according to any one of preceding claims 24-26 wherein the protective film (24) is coated with a pattern of silicone or other adhesion releasing material at the surface facing the adhesive layer (19) in such a way that a barrier is formed by the remaining non-coated protective film surface in conjunction with the adhesive layer to prevent a lateral migration of the drug preparation contained in the micro-emulsion into the skin-compatible adhesive layer (19).

Claim 28

A device according to any one of preceding claims 24-27 wherein the coated and non-coated partial areas and of the pattern on the surface of the peelable protective film (24) in contact with the adhesive layer (19) are varied in their sizes and/or in the ratio of their geometrical shapes according to the consistency of the drug preparation for optimizing the barrier effect of the uncoated partial areas and the peelability of the protective film.

Claim 32

A device according to any one of preceding claims 24-31 wherein the skin-compatible adhesive (19) consists of components which prevent a penetration by the micro-emulsion containing the drug formulation.

Claim 33

A device according to any one of preceding claims 24-32 wherein the adhesive layer (20) is formed by a hot-melt adhesive.