Device for the transdermal administration of protein or peptide drug

Claim 2

An integration-type transdermal administration device as patch-type used by attaching to the skin beeing charac­terized by the following structure: A) solvent reservoir (2) of ionizing solvent on the upper side forming an electrode (1) being open to the outside, B) drug-immersed hydrophilic polymer drug reservoir (3) forming the lower part, C) water-swellable polymer skin needle supporter (5) where plural skin needles (4) are vertically dispersed in a fixed state, D) stacking-structural adhesive layer (6) formed around the said skin needle supporter (5), E) solvent inlet (7) placed in the upper central part.

Claim 3

An integration-type transdermal administration device as patch-type used by attaching to the skin as claimed in claim 1, in which a drug reservoir (3) and skin needle supporter (5) are composed by any one or more polymers: polyacrylami­de, carboxymethylcellulose, polyvinylimine, polyacrylate, alginate, karaya gum, and gelatin.

Claim 4

An integration-type transdermal administration device as patch-type used by attaching to the skin as claimed in claim 1, in which the skin needle supporter (5), 1 to 15 pieces of skin needle (4) per the unit area (cm) is/are attached , and the skin needle (4) has the diameter ranging from 50 to 400 µm and its length protruding to the outside of drug sup­porter should be 0.2 to 2 mm.

Claim 5

A separation-type transdermal administration device as patch-type used by attaching to the skin being characterized by the following structure: A) solvent reservoir (12) of ionizing solvent on the upper side forming an electrode (11) being open to the ouside, B) semipermeable membrane (18) with a molecular cut-off ranging from 200 to 20,000 while forming the lower side of the said solven reservoir (12), C) drug-immersed hydrophilic polymer drug support (13), D) patch body (30) composed of adhesive layer formed around the said drug reservoir 13, and aside from the patch body (30), needle plate (15) in which plural skin needles (14) are vertically distrubted in a fixed state.

Claim 6

A separation-type transdermal administration device as patch-type used by attaching to the skin being characterized by the following structure: A) solvent reservoir (12) of ionizing solvent on the upper side forming an electrode (11) being open to the ouside, B) semipermeable membrane (18) with a molecular cut-off ranging from 200 to 20,000 while forming the lower side of the said solven reservoir (12), C) drug-immersed hydrophilic polymer drug support (13), D) patch body (30) composed of adhesive layer formed around the said drug reservoir 13, and aside from the patch body (30), needle plate (15) in which plural skin needles (14) are vertically distrubted in a fixed state.

Claim 7

A transdermal administration device as claimed in claim 4, in which semipermeable membrane (18) is in the groups of polypropylene, cellulose, and ethylene vinylacetate.

Claim 8

A composition of ionizing solvent, in connection with the solvent dissolving and ionizing a protein or peptide drug: in proportion to water 100 % by volume, 1 to 50 % by volume of any one or more solvents selected from sodium acetate, sodium-EDTA, sodium salicylate, salt buffer solution of phenol derivatives, acetic acid, hydrochloric acid, ammonia water, and caustic soda; 1 to 30 % by volume of polyelec­trolyte; 1 to 30 % by volume of enhancer.

Claim 9

A composition of ionizing solvent, in connection with the solvent dissolving and ionizing a protein or peptide drug: in proportion to water 100 % by volume, 1 to 50 % by volume of any one or more solvents selected from sodium acetate, sodium-EDTA, sodium salicylate, salt buffer solution of phenol derivatives, acetic acid, hydrochloric acid, ammonia water, and caustic soda; 1 to 30 % by volume of polyelec­trolyte; 1 to 30 % by volume of enhancer.

Claim 10

A composition of ionizing solvent as claimed in claim 6, in which polyelectrolyte is used by selecting from any one or more two mixtures: polyacrylamide, polyvinylimine, quadrava­lent ammonia, soluble or insoluble polymer including pyridinium, polyacreylate, carboxymethylcellulose, and alginate.

Claim 11

A composition of ionizing solvent as claimed in claim 6, in which enhancer is used by selecting from any one or more two mixtures: EDTA, citric acid, N-alkyl derivative, sodium dioxychelate, sodium tarocholate, oleic acid, saponin, and mono-olein.