Patent EP0407580A1 successfully refreshed from Google Patents.
EP0407580A1
Expired / Lapsed
EP
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Medical material and process for their production
Assignee: Asahi Kasei Medical Co Ltd
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Filing: 1989-03-15
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Granted: —
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Expires: 2009-03-15
Abstract
Abstract A medical material, an intermediate (polymeric material) therefor and a process for their production are disclosed. The medical material comprises a polymeric material having many epoxy groups bound to the functional groups of a polymer having functional groups capable of binding with an epoxy group and to the amino group of a compound having two or more amino groups whose amino group not binding with an epoxy group is bound to an epoxy group of a heparin derivative wherein the epoxy group of an epoxy compound having two or more epoxy groups is bound to the amino groups of heparin. This material carries heparin in a large amount without losing a activity and has excellent biocompatibility. The intermediate and the process heip to increase the dvantages of the above-described medical material.
Inventors
- 👤 Masatomi Sasaki
- 👤 Shinichi Kaneda
- 👤 Nobuyoshi Kashiwagi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 15:24
CPC Classifications
C; C08; C08L; C08L63/00; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; C08L63/06; Y; Y10; Y10S; Y10S623/00; Y10S623/924; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2933; Y10T428/2938; Y10T428/31504; Y10T428/31511; Y10T428/31515; Y10T428/31536; Y10T428/31855; Y10T428/3188; Y10T428/31884; Y10T428/31909; Y10T428/31913; Y10T428/31917; Y10T428/3192
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
45 words
(1) A high-molecular weight material which comprises a.high-molecular weight compound having functional groups capable of binding with epoxy groups and a polymer having a number of epoxy groups, said functional groups being bound to some of said epoxy groups, with the other epoxy groups remaining.
Claim 2
Dependent Claim
59 words
(2) A high-molecular weight material which comprises a high-molecular weight compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, with the other amino groups remaining unreacted.
Claim 3
Dependent Claim
36 words
(3) A high-molecular weight material according to claim 1 or 2 wherein the polymer having epoxy groups has a vinyl monomer as an essential component and has at least three epoxy groups per unit chain length.
Claim 4
Dependent Claim
120 words
(4) A medical material which comprises a high-molecular weight material and a heparin derivative, said high-molecular weight material comprising a high-molecular weight compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, said heparin derivative comprising heparin and an epoxy compound having at least two epoxy groups part of which is bound to amino groups in the heparin, the amino groups not bound to the epoxy groups in said high-molecular weight material being bound to the epoxy groups not bound to the amino groups in the heparin derivative.
Claim 5
Dependent Claim
33 words
(5) A medical material according to claim 4 wherein the polymer having epoxy groups has a vinyl monomer as an essential component and has at least three epoxy groups per unit chain length.
Claim 6
Dependent Claim
15 words
(6) A medical material according to claim 4 or 5 which is an antithrombotic material.
Claim 7
Dependent Claim
72 words
(7) A process for producing a high-molecular weight material which comprises a high-molecular weight compound having functional groups capable of binding with epoxy groups and a polymer having a number of epoxy groups, said functional groups being bound to some of said epoxy groups, with the other epoxy groups remaining unreacted, which process is characterized in that the above-described high-molecular weight compound is reacted with the above-described polymer in an acetone-containing solution.
Claim 8
Dependent Claim
148 words
(8) A process for producing a high-molecular weight material which comprises a high-molecular weight compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, with the other amino groups remaining unreacted, which process is characterized in that a high-molecular weight material which is the product of reaction between the above-described high-molecular weight compound and the polymer having a number of epoxy groups and in which the functional groups in the high-molecular weight compound that are capable of binding with epoxy groups are bound to some of said epoxy groups, with the other epoxy groups remaining unreacted in the reaction product, is reacted with the above-described compound having at least two amino groups in an aqueous solution.
Claim 9
Dependent Claim
172 words
(9) A process for producing a medical material which comprises a high-molecular weight material and a heparin derivative, said high-molecular weight material comprising a high-molecular weight compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, said heparin derivative comprising heparin and an epoxy compound having at least two epoxy groups part of which is bound to amino groups in the heparin, the amino groups not bound to the epoxy groups in said high-molecular weight material being bound to the epoxy groups not bound to the amino groups in the heparin derivative, which process is characterized in that a heparin derivative having the amino groups in-heparin bound to some of the epoxy groups in the epoxy compound, with the other epoxy groups remaining unreacted in the reaction product, is reacted with the above-described high-molecular weight material in an aqueous solution.
References Cited (Backward Citations)
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