EP0406485A1
Expired / Lapsed
EP
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A method for the removal of leukocytes from a leukocyte-containing suspension and filter unit for use with the method
Assignee: NPBI Nederlands Produktielaboratorium voor Bloedtransfusieapparatuur en Infusievloeistoffen BV
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Filing: 1989-07-03
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Granted: —
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Expires: 2009-07-03
Abstract
Abstract A method for removing leukocytes from a leukocyte-containing suspension by passing a leukocyte-containing suspension over a filter unit containing a filter comprising a continuous porous structure, and obtaining a leukocyte-poor liquid, whereby a continuous porous structure or a combination of porous structures is used having a pore gradient with decreasing pore size in the direction of the flow of the suspension.
Inventors
- 👤 Jan Feijen
- 👤 Anton Bruil
- 👤 Theofil Wenzel Rejda
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 11:16
CPC Classifications
B; B01; B01D; B01D69/00; B01D69/12; B01D69/1218; B01D39/00; B01D39/14; B01D39/16; B01D39/1669; B01D39/1676; B01D71/00; B01D71/06; B01D71/54; A; A61; A61M; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
63 words
A method for removing leukocytes from a leukocyte-containing suspension by passing a leukocyte-containing suspension over a filter unit containing a filter comprising a continuous porous structure, and obtaining a leukocyte-poor liquid, characterized in that a continuous porous structure or a combination of porous structures is used having a pore gradient with decreasing pore size in the direction of the flow of the suspension.
Claim 2
Independent Claim
63 words
A method for removing leukocytes from a leukocyte-containing suspension by passing a leukocyte-containing suspension over a filter unit containing a filter comprising a continuous porous structure, and obtaining a leukocyte-poor liquid, characterized in that a continuous porous structure or a combination of porous structures is used having a pore gradient with decreasing pore size in the direction of the flow of the suspension.
Claim 3
Dependent Claim
35 words
A method according to claim 1, characterized in that the continuous porous structure is a membrane or a combination of two or more stacked membranes, said membranes each having a thickness of less than 500µm.
Claim 4
Dependent Claim
38 words
A method according to claim 1, characterized in that the continuous porous structure is a foam material or a combination of two or more stacked foam materials, said foam materials each having a thickness of at least 500µm.
Claim 5
Independent Claim
28 words
A method according to claims 1-3, characterized in that the continuous porous structure is a stacked combination of one or more membranes and one or more foam materials.
Claim 6
Independent Claim
45 words
A method according to claims 1-4 characterized in that a continuous porous structure is used having a pore gradient with decreasing pore size varying from an average pore size of 10-200 µm to 3-20 µm in the direction of the flow of the leukocyte-containing suspension.
Claim 7
Dependent Claim
30 words
A method according to claim 5, characterized in that the average pore size varies from 10-50 µm to 3-15 µm in the direction of the flow of the leukocyte-containing suspension.
Claim 8
Independent Claim
35 words
A method according to claims 1-6, characterized in that the continuous porous structure is made from a polymer, a metal, a ceramic, glass, a composite or a combination of two or more of said materials.
Claim 9
Dependent Claim
23 words
A method according to claim 7, characterized in that the continuous porous structure is made from a polymer or a combination of polymers.
Claim 10
Dependent Claim
53 words
A method according to claim 8, characterized in that the continuous porous structure is made from polyurethane, poly ester, polyamide, polyether, cellulose, cellulose acetate or other cellulose derivate, polyacrylate, polymethacrylate, polyacrylonitril, polyvinylalcohol, polyvinylchloride, polypropylene, polyethylene, fluorinated polyolefin, polystyrene, polysulphone, silicon rubbers and blends of said polymers or copolymers derived thereof such as poly(ethylene-vinylacetate).
Claim 11
Dependent Claim
16 words
A method according to claim 9, characterized in that the polymer is polyurethane,polystyrene or cellulose acetate.
Claim 12
Dependent Claim
13 words
A method according to claim 10, characterized in that cellulose acetate is used.
Claim 13
Dependent Claim
79 words
A filter unit for use with the method according to claims 1-11 for removing leukocytes from a leukocyte containing suspension comprising a container provided with at least one inlet conduit means and at least one outlet conduit means, the container having a filter contained therein, characterized in that said filter is a continuous porous structure or a combination of porous structures having a pore gradient with decreasing pore size in the direction of the flow of the leukocyte-containing suspension.
Claim 14
Dependent Claim
36 words
A filter unit according to claim 12, characterized in that the continuous porous structure is a membrane or a combination of two or more stacked membranes, said membranes each having a thickness of less than 500µm.
Claim 15
Dependent Claim
37 words
A filter unit according to claim 12, characterized in that the continuous porous structure is a foam material or a combination of two or more stacked stacked foam materials each having a thickness of at least 500µm.
Claim 16
Dependent Claim
29 words
A filter unit according to claims 12-14, characterized in that the continuous porous structure is a stacked combination of one or more membranes and one or more foam materials.
Claim 17
Dependent Claim
44 words
A filter unit according to claims 12-15, characterized in that the continuous porous structure has a pore gradient with decreasing pore size varying from an average pore size of 10-200 µm to 3-20 µm in the direction of the flow of the leukocyte-containing suspension.
Claim 18
Dependent Claim
31 words
A filter unit according to claim 16, characterized in that the average pore size varies from 10-50 µm to 3-15 µm in the direction of the flow of the leukocyte-containing suspension.
Claim 19
Dependent Claim
36 words
A filter unit according to claims 12-17, characterized in that the continuous porous structure is made from a polymer, a metal, a ceramic, glass, a composite, or a combination of two or more of said materials.
Claim 20
Dependent Claim
18 words
A filter unit according to claim 18, characterized in that the continuous structure is made from a polymer.
Claim 21
Dependent Claim
53 words
A filter unit according to claim 19, characterized in that the continuous porous structure is made from polyurethane, polyester, polyamide, polyether, cellulose, cellulose acetate or other cellulose derivative, poyacrylate, polymethacrylate, polyacrylonitril, polyvinylalcohol, polyvinylchloride, polypropylene, polyethylene, fluorinated polyolefin, polystyrene, polysulphone, silicon rubbers and blends of said polymers or copolymers derived thereof such as poly(ethylene-vinylacetate).
Claim 22
Dependent Claim
17 words
A filter unit according to claim 20,characterized in that the polymer is polyurethane, polystyrene or cellulose acetate.
Claim 23
Dependent Claim
15 words
A filter unit according to claim 21, characterized in that the polymer is cellulose acetate.
References Cited (Backward Citations)
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