Patent EP0402049A2 successfully refreshed from Google Patents.
EP0402049A2
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EP
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Alpha-Glycosyl hesperidin, and its preparation and uses
Assignee: Hayashibara Seibutsu Kagaku Kenkyujo KK
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Filing: 1990-05-31
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Granted: —
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Expires: 2010-05-31
Abstract
Abstract α-Glycosyl hesperidin, a novel hesperidin derivative wherein equimolar or more D-glucose residues are bound to hesperidin via the d-bond, is formed by a saccharide-transferring enzyme in a liquid containing hesperidin and α-glucosyl saccharide. The α-glycosyl hesperidin is easily recovered from the reaction mixture with a synthetic macroporous resin. α-Glycosyl hesperidin is superior in water-solubility, substantially tasteless and odorless, free of toxicity, and readily hydrolyzable in vivo into hesperidin and D-glucose to exhibit the physiological activity inherent to hesperidin. Thus, α-glycosyl hesperidin is favorably usable in vitamin P-enriching agents, foods, beverages, tobaccos, foods, pet foods, pharmaceuticals for susceptive diseases, cosmetics and plastics.
Inventors
- 👤 Hiromi Hijiya
- 👤 Toshio Miyake
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 14:24
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/60; A61K8/602; A23; A23B; A23B2/00; A23B2/70; A23B2/725; A23B2/729; A23B2/771; A23G; A23G3/00; A23G3/34; A23G3/346; A23G3/36; A23K; A23K20/00; A23K20/10; A23K20/163; A23L; A23L27/00; A23L27/70; A23L27/75; A23L33/00; A23L33/10; A23L33/15; A23L5/00; A23L5/40; A23L5/42; A23L5/43; A24; A24B; A24B15/00; A24B15/18; A24B15/28; A24B15/30; A61K8/67; A61K8/676; A61P; A61P3/00; A61P3/02; A61P37/00; A61P37/08; A61Q; A61Q17/00; A61Q17/04; A61Q19/00; A61Q19/02; A61Q19/10; C; C07; C07H; C07H17/00; C07H17/04; C07H17/06; C07H17/065; C07H17/07; C12; C12P; C12P19/00; C12P19/14; C12P19/16; C12P19/18; C12P19/44; C12P19/60; A23G2200/00; A23G2200/04; A23V; A23V2002/00; A61K2800/00; A61K2800/40; A61K2800/52; A61K2800/522
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
15 words
α-Glycosyl hesperidin wherein equimolar or more D-glucose residues are bound to hesperidin via the α-bond.
Claim 2
Dependent Claim
15 words
α-Glycosyl hesperidin wherein equimolar or more D-glucose residues are bound to hesperidin via the α-bond.
Claim 3
Dependent Claim
10 words
The α-glycosyl hesperidin of claim 1, which is α-glucosyl hesperidin.
Claim 4
Dependent Claim
32 words
A process to prepare α-glycosyl hesperidin, comprising: allowing a saccharide-transferring enzyme to act on a liquid containing hesperidin together with an α-glucosyl saccharide to form α-glycosyl hesperidin; and recovering the α-glycosyl hesperidin.
Claim 5
Dependent Claim
32 words
A process to prepare α-glycosyl hesperidin, comprising: allowing a saccharide-transferring enzyme to act on a liquid containing hesperidin together with an α-glucosyl saccharide to form α-glycosyl hesperidin; and recovering the α-glycosyl hesperidin.
Claim 6
Dependent Claim
28 words
The process of claim 3, wherein the recovering step comprises: purifying the liquid by allowing it to contact with a macroporous synthetic resin; and recovering the α-glycosyl hesperidin.
Claim 7
Dependent Claim
29 words
The process of claim 3, wherein said saccharide-transferring enzyme is a member selected from the group consisting of α-glucosidase (EC 3.2.1.20), cyclomaltodextrin glucanotransferase (EC 2.4.1.19), and α-amylase (EC 3.2.1.1).
Claim 8
Dependent Claim
14 words
The process of claim 3, wherein said liquid contains at least 0.005 w/v hesperidin.
Claim 9
Dependent Claim
28 words
The process of claim 3, wherein said α-glucosyl saccharide is a member selected from the group consisting of partial starch hydrolysate, liquefied starch, gelatinized starch, and mixtures thereof.
Claim 10
Dependent Claim
19 words
The process of claim 3, wherein the concentration of said α-glucosyl saccharide is 0.5-50-fold higher than that of hesperidin.
Claim 11
Dependent Claim
11 words
The process of claim 3, wherein said liquid is in suspension.
Claim 12
Dependent Claim
11 words
The process of claim 3, wherein said liquid is in solution.
Claim 13
Dependent Claim
15 words
The process of claim 10, wherein said liquid is obtainable by dissolving hesperidin by heating.
Claim 14
Dependent Claim
18 words
The process of claim 10, wherein said liquid obtainable by dissolving hesperidin at an alkaline pH exceeding 7.0.
Claim 15
Dependent Claim
7 words
Foods and beverages, which contain α-glycosyl hesperidin.
Claim 16
Dependent Claim
7 words
Foods and beverages, which contain α-glycosyl hesperidin.
Claim 17
Dependent Claim
15 words
The foods and beverages of claim 13, wherein said α-glycosyl hesperidin is an α-glucosyl hesperidin.
Claim 18
Dependent Claim
19 words
The foods and beverages of claim 13, wherein said α-glycosyl hesperidin is prepared by the process of claim 3.
Claim 19
Dependent Claim
12 words
The foods and beverages of claim 13, which additionally contains vitamin C.
Claim 20
Dependent Claim
19 words
A pharmaceutical for susceptive diseases, which contains together with a pharmaceutically-acceptable carrier an α-glycosyl hesperidin as the effective ingredient.
Claim 21
Dependent Claim
19 words
A pharmaceutical for susceptive diseases, which contains together with a pharmaceutically-acceptable carrier an α-glycosyl hesperidin as the effective ingredient.
Claim 22
Dependent Claim
12 words
The pharmaceutical of claim 17, wherein said α-glycosyl hesperidin is α-glucosyl hesperidin.
Claim 23
Dependent Claim
17 words
The pharmaceutical of claim 17, wherein said α-glycosyl hesperidin is prepared by the process of claim 3.
Claim 24
Dependent Claim
10 words
The pharmaceutical of claim 17, which additionally contains vitamin C.
Claim 25
Dependent Claim
11 words
A cosmetic which contains as the effective ingredient an α-glycosyl hesperidin.
Claim 26
Dependent Claim
11 words
A cosmetic which contains as the effective ingredient an α-glycosyl hesperidin.
Claim 27
Dependent Claim
12 words
The cosmetic of claim 21, wherein said glycosyl hesperidin is α-glucosyl hesperidin.
Claim 28
Dependent Claim
17 words
The cosmetic of claim 21, wherein said glycosyl hesperidin is prepared by the process of claim 3.
Claim 29
Dependent Claim
10 words
The cosmetic of claim 21, which additionally contains vitamin C.
Claim 30
Dependent Claim
11 words
An α-glycosyl hesperidin whenever prepared by the process of claim 3.
References Cited (Backward Citations)
No citation records indexed.
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