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EP0402049A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Alpha-Glycosyl hesperidin, and its preparation and uses

Assignee: Hayashibara Seibutsu Kagaku Kenkyujo KK
•
Filing: 1990-05-31
•
Granted: —
•
Expires: 2010-05-31
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Abstract

Abstract α-Glycosyl hesperidin, a novel hesperidin derivative wherein equimolar or more D-glucose residues are bound to hesperidin via the d-bond, is formed by a saccharide-trans­ferring enzyme in a liquid containing hesperidin and α-glucosyl saccharide. The α-glycosyl hesperidin is easily recovered from the reaction mixture with a synthetic macroporous resin. α-Glycosyl hesperidin is superior in water-solubility, substan­tially tasteless and odorless, free of toxicity, and readily hydrolyzable in vivo into hesperidin and D-glucose to exhibit the physiological activity inherent to hesperidin. Thus, α-glycosyl hesperidin is favorably usable in vitamin P-­enriching agents, foods, beverages, tobaccos, foods, pet foods, pharmaceuticals for susceptive diseases, cosmetics and plas­tics.

Inventors

  • 👤 Hiromi Hijiya
  • 👤 Toshio Miyake

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-11-09 14:14
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/60; A61K8/602; A23; A23B; A23B2/00; A23B2/70; A23B2/725; A23B2/729; A23B2/771; A23G; A23G3/00; A23G3/34; A23G3/346; A23G3/36; A23K; A23K20/00; A23K20/10; A23K20/163; A23L; A23L27/00; A23L27/70; A23L27/75; A23L33/00; A23L33/10; A23L33/15; A23L5/00; A23L5/40; A23L5/42; A23L5/43; A24; A24B; A24B15/00; A24B15/18; A24B15/28; A24B15/30; A61K8/67; A61K8/676; A61P; A61P3/00; A61P3/02; A61P37/00; A61P37/08; A61Q; A61Q17/00; A61Q17/04; A61Q19/00; A61Q19/02; A61Q19/10; C; C07; C07H; C07H17/00; C07H17/04; C07H17/06; C07H17/065; C07H17/07; C12; C12P; C12P19/00; C12P19/14; C12P19/16; C12P19/18; C12P19/44; C12P19/60; A23G2200/00; A23G2200/04; A23V; A23V2002/00; A61K2800/00; A61K2800/40; A61K2800/52; A61K2800/522

Claims Analysis

Total Claims: 30
Claim 1
Independent Claim 15 words
α-Glycosyl hesperidin wherein equimolar or more D-glucose residues are bound to hesperidin via the α-bond.
Claim 2
Dependent Claim 15 words
α-Glycosyl hesperidin wherein equimolar or more D-glucose residues are bound to hesperidin via the α-bond.
Claim 3
Dependent Claim 10 words
The α-glycosyl hesperidin of claim 1, which is α-glucosyl hesperidin.
Claim 4
Dependent Claim 32 words
A process to prepare α-glycosyl hesperidin, comprising: allowing a saccharide-transferring enzyme to act on a liquid containing hesperidin together with an α-glucosyl saccharide to form α-glycosyl hesperidin; and recovering the α-glycosyl hesperidin.
Claim 5
Dependent Claim 32 words
A process to prepare α-glycosyl hesperidin, comprising: allowing a saccharide-transferring enzyme to act on a liquid containing hesperidin together with an α-glucosyl saccharide to form α-glycosyl hesperidin; and recovering the α-glycosyl hesperidin.
Claim 6
Dependent Claim 28 words
The process of claim 3, wherein the recovering step comprises: purifying the liquid by allowing it to contact with a macroporous synthetic resin; and recovering the α-glycosyl hesperidin.
Claim 7
Dependent Claim 29 words
The process of claim 3, wherein said saccharide-­transferring enzyme is a member selected from the group con­sisting of α-glucosidase (EC 3.2.1.20), cyclomaltodextrin glucanotransferase (EC 2.4.1.19), and α-amylase (EC 3.2.1.1).
Claim 8
Dependent Claim 14 words
The process of claim 3, wherein said liquid contains at least 0.005 w/v hesperidin.
Claim 9
Dependent Claim 28 words
The process of claim 3, wherein said α-glucosyl saccharide is a member selected from the group consisting of partial starch hydrolysate, liquefied starch, gelatinized starch, and mixtures thereof.
Claim 10
Dependent Claim 19 words
The process of claim 3, wherein the concentra­tion of said α-glucosyl saccharide is 0.5-50-fold higher than that of hesperidin.
Claim 11
Dependent Claim 11 words
The process of claim 3, wherein said liquid is in suspension.
Claim 12
Dependent Claim 11 words
The process of claim 3, wherein said liquid is in solution.
Claim 13
Dependent Claim 15 words
The process of claim 10, wherein said liquid is obtainable by dissolving hesperidin by heating.
Claim 14
Dependent Claim 18 words
The process of claim 10, wherein said liquid obtainable by dissolving hesperidin at an alkaline pH exceeding 7.0.
Claim 15
Dependent Claim 7 words
Foods and beverages, which contain α-glycosyl hesperidin.
Claim 16
Dependent Claim 7 words
Foods and beverages, which contain α-glycosyl hesperidin.
Claim 17
Dependent Claim 15 words
The foods and beverages of claim 13, wherein said α-glycosyl hesperidin is an α-glucosyl hesperidin.
Claim 18
Dependent Claim 19 words
The foods and beverages of claim 13, wherein said α-glycosyl hesperidin is prepared by the process of claim 3.
Claim 19
Dependent Claim 12 words
The foods and beverages of claim 13, which additionally contains vitamin C.
Claim 20
Dependent Claim 19 words
A pharmaceutical for susceptive diseases, which contains together with a pharmaceutically-acceptable carrier an α-glycosyl hesperidin as the effective ingredient.
Claim 21
Dependent Claim 19 words
A pharmaceutical for susceptive diseases, which contains together with a pharmaceutically-acceptable carrier an α-glycosyl hesperidin as the effective ingredient.
Claim 22
Dependent Claim 12 words
The pharmaceutical of claim 17, wherein said α-glycosyl hesperidin is α-glucosyl hesperidin.
Claim 23
Dependent Claim 17 words
The pharmaceutical of claim 17, wherein said α-glycosyl hesperidin is prepared by the process of claim 3.
Claim 24
Dependent Claim 10 words
The pharmaceutical of claim 17, which addition­ally contains vitamin C.
Claim 25
Dependent Claim 11 words
A cosmetic which contains as the effective ingredient an α-glycosyl hesperidin.
Claim 26
Dependent Claim 11 words
A cosmetic which contains as the effective ingredient an α-glycosyl hesperidin.
Claim 27
Dependent Claim 12 words
The cosmetic of claim 21, wherein said glycosyl hesperidin is α-glucosyl hesperidin.
Claim 28
Dependent Claim 17 words
The cosmetic of claim 21, wherein said glycosyl hesperidin is prepared by the process of claim 3.
Claim 29
Dependent Claim 10 words
The cosmetic of claim 21, which additionally contains vitamin C.
Claim 30
Dependent Claim 11 words
An α-glycosyl hesperidin whenever prepared by the process of claim 3.

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