Patent EP0385118A2 successfully refreshed from Google Patents.
EP0385118A2
Expired / Lapsed
EP
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Use of compounds containing or binding sialic acid to neutralize bacterial toxins
Assignee: Snow Brand Milk Products Co Ltd
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Filing: 1990-01-30
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Granted: —
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Expires: 2010-01-30
Abstract
Abstract Sialic acid binding proteins, sialic acid-binding peptides and sialic acid containing oligosaccharides that are effective components of a baterial enterotoxin neutralizer according to the present invention all interfere with the binding of enterotoxins, including the cholera toxin, to receptors so as to exert an effect of neutralziing the toxicity, thus being utilized as an effective neutralizer. Furthermore, all the components according to the present invention are confirmed to be safe and, moreover, available cheaply and abundantly from waste matter produced during processes of cow's milk or the like, which makes the present invention economically advantageous for practical use.
Inventors
- 👤 Hiroko 503 De Le Sion Kyowa Isoda
- 👤 Yoshihiro Kawasaki
- 👤 Morimasa Tanimoto
- 👤 Shunichi Dosako
- 👤 Tadashi Idota
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 08:06
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/40; A61K31/00; A61K31/70; A61K38/1703; A61K38/1709; A61P; A61P31/00; A61P31/04; A61P39/00; A61P39/02; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
47 words
A bacterial enterotoxin neutralizer which contains as an effective component(s) one or more kinds of sialic acid-containing substances selected from the group consisting of sialic acid-binding proteins derived from cow's milk, sialic acid-binding peptides obtained by treating said sialic acid-binding proteins with protease and sialic acid-containing oligosaccharides.
Claim 2
Dependent Claim
47 words
A bacterial enterotoxin neutralizer which contains as an effective component(s) one or more kinds of sialic acid-containing substances selected from the group consisting of sialic acid-binding proteins derived from cow's milk, sialic acid-binding peptides obtained by treating said sialic acid-binding proteins with protease and sialic acid-containing oligosaccharides.
Claim 3
Dependent Claim
20 words
A bacterial enterotoxin neutralizer as set forth in claim 1, in which said sialic acid-binding protein is lactoferrin or kappa-casein.
Claim 4
Dependent Claim
19 words
A bacterial enterotoxin neutralizer as set forth in claim 1, in which said sialic acid-binding peptide is kappa-casein glycomacropeptide.
Claim 5
Dependent Claim
18 words
A bacterial enterotoxin neutralizer as set forth in claim 1, in which said sialic acid-binding oligosaccharide is sialyllactose.
Claim 6
Dependent Claim
21 words
A bacterial enterotoxin neutralizer as set forth in claim 2, which is a tablet containing 100 mg of lactoferrin per tablet.
Claim 7
Dependent Claim
27 words
A bacterial enterotoxin neutralizer as set forth in claim 3, which is a powdered preparation for injection, containing said kappa-casein glycomacropeptide at a rate of 10% (w/v).
Claim 8
Dependent Claim
41 words
A bacterial enterotoxin neutralizer as set forth in claim 1, which is a capsular preparation prepared by mixing ganglioside G D3 , lactoferrin, kappa-casein glycomacropeptide and sialyllactose, at rates of 10%, 50%, 30% and 10%, respectively, and granulating the resultant mixture.
Claim 9
Independent Claim
58 words
A method of neutralizing bacterial enterotoxins characterized in that a sialic acid-containing substance(s) selected from the group consisting of sialic acid-binding proteins, sialic acid-binding peptides obtained by treating said sialic acid-binding proteins with protease and sialic acid-containing oligosaccharide is(are) administered singly or as a mixture at a dose of 6 to 300 mg par day for an adult.
Claim 10
Independent Claim
58 words
A method of neutralizing bacterial enterotoxins characterized in that a sialic acid-containing substance(s) selected from the group consisting of sialic acid-binding proteins, sialic acid-binding peptides obtained by treating said sialic acid-binding proteins with protease and sialic acid-containing oligosaccharide is(are) administered singly or as a mixture at a dose of 6 to 300 mg par day for an adult.
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JPS5572819A
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JPS59918A
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JPS59181497A
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JPS59184197A
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JPS61145200A
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JPS63284199A
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JPS63284133A
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