Patent EP0384642A1 successfully refreshed from Google Patents.
EP0384642A1
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EP
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Dispensing device
Assignee: BTG International Ltd
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Filing: 1990-02-15
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Granted: —
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Expires: 2010-02-15
Abstract
Abstract Novel devices for the controlled release of active materials especially pharmaceuticals comprise a capsule formed from two seperable pieces at least part of the capsule walls is water permeable. The capsule contains a water sensitive material which on contact with water causes the two pieces to separate. In the preferred embodiment the devices comprise a generally cylindrical tube closed at one or both endsby a water swellable plug. The devices find particular application as oral dosage forms for use in man.
Inventors
- 👤 Abdul Rashid
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 07:32
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/4808
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
72 words
A controlled release device comprising a water permeable capsule containing at least one active material characterised in that the wall of the said capsule is formed from at least two separable pieces and the capsule contains a quantity of at least one water sensitive material which when wet will cause a positive pressure to be exerted on the interior wall of the capsule and result in the separation of the two pieces.
Claim 2
Dependent Claim
72 words
A controlled release device comprising a water permeable capsule containing at least one active material characterised in that the wall of the said capsule is formed from at least two separable pieces and the capsule contains a quantity of at least one water sensitive material which when wet will cause a positive pressure to be exerted on the interior wall of the capsule and result in the separation of the two pieces.
Claim 3
Dependent Claim
36 words
A device according to Claim 1 characterised in that a first piece of the wall of the capsule defines at least one orifice which orifice is closed by a second separable piece which is a plug.
Claim 4
Dependent Claim
28 words
A device according to Claim 2 characterised in that the first piece is a generally cylindrical tube which is closed at one end and open at the other.
Claim 5
Dependent Claim
23 words
A device according to Claim 2 characterised in that the first piece is a generally cylindrical tube which is open at both ends.
Claim 6
Independent Claim
21 words
A device according to any of claims 2 to 4 characterised in that the second separable piece is a cylindrical plug.
Claim 7
Independent Claim
30 words
A device according to any of claims 2 to 5 characterised in that wherein a retaining means is provided on the interior face of the orifice which engages the plug.
Claim 8
Independent Claim
21 words
A device according to any of the preceding claims characterised in that the water sensitive material is a water swellable material.
Claim 9
Dependent Claim
55 words
A device according to Claim 7 characterised in that the water swellable material is selected from the group comprising poly N vinyl pyrolidones, cross linked cellulosic derivates, cross linked dextrans, cross linked hydroxyethyl methacrylate, cross linked gelatins and starches, cross linked (meth)acrylic acid copolymer hydrogels, cross linked polyacrylamide hydrogels and cross linked polyethylene glycol hydrogels.
Claim 10
Dependent Claim
16 words
A device according to Claim 8 characterised in that the water swellable material is a hydrogel.
Claim 11
Independent Claim
33 words
A device according to any of claims 7 to 9 characterised in that the water swellable material is capable of swelling to at least 1.5 times its original volume by absorption of water.
Claim 12
Independent Claim
37 words
A device according to any of claims 7 to 10 characterised in that the water swellable material is a hydrogel derived from a homo- or co-poly(alkylene oxide) cross linked by reaction with isocyanate or unsaturated ether groups.
Claim 13
Independent Claim
20 words
A device according to any of the preceding claims characterised in that the water sensitive material is a particulate solid.
Claim 14
Independent Claim
21 words
A device according to any of claims 1 to 11 characterised in that the water sensitive material is a preformed monolith.
Claim 15
Dependent Claim
39 words
A device according to claim 13 characterised in that the monolith takes the form of a rod, bar or coil adapted so that when inserted into the capsule its longitudinal axis lies along the longitudinal axis of the capsule.
Claim 16
Independent Claim
18 words
A device according to any of the preceding claims characterised in that the capsule contains particulate active material.
Claim 17
Independent Claim
24 words
A device according to any of claims 1 to 14 characterised in that the capsule contains the active material in a modified dosage form.
Claim 18
Independent Claim
39 words
A device according to any of the preceding claims characterised in that the contents of the capsule are arranged so that the active material is adjacent to the point at which the two pieces of the capsule will separate.
Claim 19
Independent Claim
27 words
A device according to any of the preceding claims characterised in that the first piece of the capsule is constructed so as to be impermeable to water.
Claim 20
Dependent Claim
40 words
A device according to claim 18 characterised in that the said first piece is constructed from a hydrophobic material selected from the group comprising polyethylene, polypropylene, polymethyl methacrylate, polyvinyl chloride, polystyrene, polyurethanes, polytetrafluoroethylene, nylons, polyformaldehydes, polyesters, cellulose acetate and nitrocellulose.
Claim 21
Independent Claim
27 words
A device according to any of claims 1 to 18 characterised in that the first piece of the capsule is constructed so as to be water permeable.
Claim 22
Dependent Claim
18 words
A device according to claim 20 characterised in that the said first piece is formed from a hydrogel.
Claim 23
Dependent Claim
37 words
A device according to claim 21 characterised in that the said first piece is constructed from a hydrogel derived from a homo- or co-poly (alkylene oxide) cross linked by reaction with isocyanate or unsaturated cyclic ether groups.
Claim 24
Independent Claim
24 words
A device according to any of the preceding claims characterised in that the said second piece is constructed so as to be water permeable.
Claim 25
Dependent Claim
17 words
A device according to claim 23 characterised in that the second piece is constructed from a hydrogel.
Claim 26
Dependent Claim
35 words
A device according to claim 24 characterised in that the second piece is constructed from a hydrogel derived from a homo- or co-poly(alkylene oxide) cross linked by reaction with isocyanate or unsaturated cyclic ether group.
Claim 27
Independent Claim
43 words
A device according to any of the preceding claims adopted for use as an oral dosage form in man characterised in that the capsule has a length of from 10 to 30 mm and an external diameter of from 1 to 20 mm.
Claim 28
Dependent Claim
21 words
A device according to claim 26 characterised in that the exterior surface of the capsule is provided with an enteric coating.
Claim 29
Independent Claim
19 words
A device according to any of the preceding claims substantially as hereinbefore described with reference to the foregoing examples.
References Cited (Backward Citations)
GB436236A
Cited
US3952741A
Cited
US3952741B1
Cited
EP0132384A2
Cited
EP0153825A2
Cited
GB2206047A
Cited
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