Patent EP0378404A2 successfully refreshed from Google Patents.
EP0378404A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Dispensing devices powered by hydrogel
Assignee: Pfizer Inc
•
Filing: 1990-01-10
•
Granted: —
•
Expires: 2010-01-10
Abstract
Abstract This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by hydrogel, are powered by hydrogel, comprising a layer made of a mixture of one or more beneficial agents and a hydrogel, a second layer of hydrogel and a coating. This invention also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such hydrogel powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprises administering to or otherwise placing the devices of this invention in the environment of use.
Inventors
- 👤 William John Curatolo
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 12:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/0002; A61K9/0004; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
70 words
A dispensing device for dispensing to an environment an agent having a functionality with respect thereto or to a subject therein or of which the environment forms part, the device comprising a coating (3) through which the agent has passage when the device is disposed in and exposed to said environment and a core comprising a mixture (6) which comprises a hyrdrogel (5) and a charge of said agent (4).
Claim 2
Dependent Claim
70 words
A dispensing device for dispensing to an environment an agent having a functionality with respect thereto or to a subject therein or of which the environment forms part, the device comprising a coating (3) through which the agent has passage when the device is disposed in and exposed to said environment and a core comprising a mixture (6) which comprises a hyrdrogel (5) and a charge of said agent (4).
Claim 3
Dependent Claim
45 words
A dispensing device as claimed in Claim 1 and which comprises:- (a) a core which comprises a mixture (6) comprising one or more beneficial agents (4) and hydrogel (5); and (b) a coating (3) containing a plurality of pores (2) which coating surrounds the mixture.
Claim 4
Dependent Claim
74 words
A dispensing device as claimed in Claim 2 and which comprises:- (a) a first layer (6) comprising a mixture of one or more beneficial agents (4) and hydrogel (5); (b) a second layer (7) disposed in overlying or underlying adjacent contacting relation to said first layer (6) and comprising hydrogel (8); and (c) a coating (3) containing a plurality of pores (2) which coating surrounds the combination of said first and second layers (6,7).
Claim 5
Dependent Claim
64 words
A dispensing device as claimed in Claim 2 and which comprises:- (a) an innermost layer (7) comprising hydrogel (8); (b) an outermost layer (6) adjacent to and surrounding the innermost layer (7) and comprising a mixture of one or more beneficial agents (4) and hydrogel (5); and (c) a coating (3) containing a plurality of pores (2) which coating surrounds the outermost layer (6).
Claim 6
Dependent Claim
44 words
A dispensing device as claimed in Claim 1 and which comprises:- (a) a core which comprises a mixture (6) comprising one or more beneficial agents (4) and hydrogel (5); and (b) a coating (3) containing at least one hole which coating surrounds the mixture.
Claim 7
Dependent Claim
80 words
A dispensing device as claimed in Claim 5 and which comprises:- (a) a first layer (6) comprising a mixture of one or more beneficial agents (4) and hydrogel (5); (b) a second layer (7) disposed in overlying or underlying adjacent contacting relation to said first layer (6) and comprising hydrogel (8); and (c) a coating (3) containing at least one hole adjacent to the first layer (6) which coating (3) surrounds the combination of said first and second layers (6,7).
Claim 8
Dependent Claim
63 words
A dispensing device as claimed in Claim 5 and which comprises: (a) an innermost layer (7) comprising hydrogel (8); (b) an outermost layer (6) adjacent to and surrounding the innermost layer (7) and comprising a mixture of one or more beneficial agents (4) and hydrogel (5); and (c) a coating (3) containing at least one hole which coating surrounds the outermost layer (6).
Claim 9
Dependent Claim
40 words
A dispensing device as claimed in any one of Claims 2 to 7 wherein the coating (3) contains a plurality of pores (2) and at least one hole in communication with the mixture (6) comprising hydrogel (5) and agent (4).
Claim 10
Dependent Claim
25 words
A dispensing device as claimed in any one of Claims 5 to 7 wherein the coating (3) comprises a polymer and one or more porosigens.
Claim 11
Dependent Claim
49 words
A dispensing device as claimed in Claim 1 and which comprises:- (a) a core which comprises a mixture (6) comprising one or more beneficial agents (4) and hydrogel (5); and (b) a coating (3) which surrounds the mixture (6) and which comprises a polymer and one or more porosigens.
Claim 12
Dependent Claim
78 words
A dispensing device as claimed in Claim 10 and which comprises:- (a) a first layer (6) comprising a mixture of one or more beneficial agents (4) and hydrogel (5); (b) a second layer (7) disposed in overlying or underlying adjacent contacting relation to said first layer (6) and comprising hydrogel (8); and (c) a coating (3) which comprises a polymer and one or more porosigens and which coating surrounds the combination of said first and second layers (6,7).
Claim 13
Dependent Claim
66 words
A dispensing device as claimed in Claim 10 and which comprises: (a) an innermost layer (7) comprising hydrogel (5); (b) an outermost layer (6) adjacent to and surrounding the innermost layer (7) and comprising a mixture of one or more beneficial agents (4) and hydrogel; and (c) a coating (3) which surrounds the outermost layer (6) and which comprises a polymer and one or more porosigens.
Claim 14
Dependent Claim
66 words
A dispensing device as claimed in any one of Claims 9 to 12 wherein the porosigen is one or more water-soluble polymers, one or more water-soluble polymers and one or more inorganic salts, one or more water-soluble polymers and one or more water-soluble particulate organic compounds or salts thereof, or one or more inorganic salts and one or more water-soluble particulate organic compounds or salts thereof.
Claim 15
Dependent Claim
27 words
A dispensing device as claimed in Claim 13 wherein the water-soluble polymer is hydroxypropyl cellulose, polyethylene glycol, polyethylene oxide or a mixture of two or more thereof.
Claim 16
Dependent Claim
23 words
A dispensing device as claimed in Claim 13 wherein the water-soluble polymer is polyethylene glycol-600 and the water-soluble particulate organic compound is sucrose.
Claim 17
Dependent Claim
19 words
A dispensing device as claimed in any preceding claim wherein the mixture (6) additionally comprises an osomotically effective solute.
Claim 18
Dependent Claim
101 words
A dispensing device as claimed in any preceding claim wherein the core comprises either an innermost layer (7) comprising hydrogel (5) and an outermost layer (6) adjacent to and surrounding the innermost layer (7) and comprising a mixture of one or more beneficial agents (4) and hydrogel (5) or a first layer (6) comprising a mixture of one or more beneficial agents (4) and hydrogel (5) and a second layer (7) disposed in overlying or underlying adjacent contacting relation to said first layer (6) and comprising hydrogel (8); and wherein one or both such layers (6,7) include an osmotically effective solute.
Claim 19
Dependent Claim
30 words
A dispensing device as claimed in any preceding claim wherein the beneficial agent (4) is a drug; the hydrogel (5) is polyethylene oxide; and the coating (3) comprises cellulose acetate.
Claim 20
Dependent Claim
19 words
A capsule which comprises a water-soluble wall encapsulating one or more dispensing devices as claimed in any preceding claim.
Claim 21
Dependent Claim
60 words
A method for the controlled delivery of one or more beneficial agents to an environment of use other than for diagnostic or therapeutic purposes practiced on a human or non-human animal body which method comprises placing into said environment a dispensing device as claimed in any one of Claims 1 to 18 or a capsule as claimed in Claim 19.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.