Patent EP0369764A2 successfully refreshed from Google Patents.
EP0369764A2
Expired / Lapsed
EP
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Composition for reducing postsurgical adhesions and its use
Assignee: Mediventures Inc
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Filing: 1989-11-15
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Granted: —
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Expires: 2009-11-15
Abstract
Abstract A composition for use in the treatment of the human or animal body by reducing post-surgical adhesion formation/reformation following surgical injury to mammalian peritoneal or pleural cavity tissue or organs situated therein which comprises a polyoxyalkylene block copolymer of the formula: Y[(A) E―H] x (I) wherein A is an oxyalkylene moiety having an oxygen/carbon atom ratio of less than 0.5, x is at least 1 Y is derived from water or an organic compound containing x reactive hydrogen atoms, E is a polyoxyethylen moiety, n has a value such that the average molecular weight of A is at least about 500 to about 900, as determined by the hydroxyl number of an intermediate, Y[(A)―H] x (II) and the total average molecular weight of the copolymer is at least 5000.
Inventors
- 👤 Raymond L. Henry
- 👤 Richard E. Leach
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 11:29
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/745; B; B82; B82Y; B82Y5/00; A61K31/765; A61K31/77; A61K31/785; A61L; A61L31/00; A61L31/04; A61L31/06; A61P; A61P1/00; A61P43/00
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
128 words
A composition for use in the treatment of the human or animal body by reducing post-surgical adhesion formation/reformation following surgical injury to mammalian peritoneal or pleural cavity tissue or organs situated therein which comprises a polyoxyalkylene block of the formula: Y[(A) E―H] x (I) wherein A is an oxyalkylene moiety having an oxygen/carbon atom ratio of less than 0.5, x is at leaqst 1 Y is derived from water or an organic compound containing x reactive hydrogen atoms, E is a polyoxyethylen moiety, n has a value such that the average molecular weight of A is at least about 500 to about 900, as determined by the hydroxyl number of an intermediate, Y[(A)―H] x (II) and the total average molecular weight of the copolymer is at least 5000.
Claim 2
Dependent Claim
128 words
A composition for use in the treatment of the human or animal body by reducing post-surgical adhesion formation/reformation following surgical injury to mammalian peritoneal or pleural cavity tissue or organs situated therein which comprises a polyoxyalkylene block of the formula: Y[(A) E―H] x (I) wherein A is an oxyalkylene moiety having an oxygen/carbon atom ratio of less than 0.5, x is at leaqst 1 Y is derived from water or an organic compound containing x reactive hydrogen atoms, E is a polyoxyethylen moiety, n has a value such that the average molecular weight of A is at least about 500 to about 900, as determined by the hydroxyl number of an intermediate, Y[(A)―H] x (II) and the total average molecular weight of the copolymer is at least 5000.
Claim 3
Dependent Claim
31 words
A composition according to claim 1, wherein A is a polyoxyalkylene moiety, x is at least 2, and E is polyoxyethylene moiety constituting at least 60% by weight of the copolymer..
Claim 4
Dependent Claim
21 words
A composition according to claim 2, wherein E is a polyoxyethylene moiety constituting at least 70% by weight of the copolymer.
Claim 5
Dependent Claim
24 words
A composition according to any of claims 1 to 3, wherein Y is derived from a water-solution compound having 1 to 6 carbon atoms.
Claim 6
Dependent Claim
24 words
A composition according to claim 4, wherein Y is derived from a compound selected from propylene glycol, glycerin, pentaerythritol, trimethylolpropane, ethylenediamine, and mixtures thereof.
Claim 7
Dependent Claim
36 words
A composition according to any of claims 1 to 5, wherein the copolymer is selected from a polyoxyethylene-polyoxybutylene block copolymer, a polyoxyethylene-polyoxypropylene block copolymer and mixtures thereof, and wherein the composition includes physiologically acceptable carrier liquid.
Claim 8
Dependent Claim
35 words
A composition according to claim 6, wherein the copolymer is selected from block copolymers which form aqueous gels at a concentration of about 10 to 40% by weight of the total weight of said composition.
Claim 9
Dependent Claim
12 words
A composition according to claim 7, wherein the carrier liquid is water.
Claim 10
Dependent Claim
40 words
A composition according to any of claims 6 to 8, wherein Y is derived from propylene glycol, A is the residue of propylene oxide, and the intermediate of Formula II has an average molecular weight of at least about 900.
Claim 11
Dependent Claim
40 words
A composition according to any of claims 6 to 8, wherein Y is derived from butylene glycol, A is the residue of butylene oxide, and the intermediate of Formula II has an average molecular weight of at least about 500.
Claim 12
Dependent Claim
108 words
A composition according to any of claims 6 to 10, wherein the copolymer has: HO(C₂H₄O) b (C₄H₈O) a (C₂H₄O) b H (III) wherein a is an integer such that the hydrophobe base represented by (C₄H₈O) has a molecular weight of at least 1000, as determined by hydroxyl number, or HO(C₂H₄O) b (C₃H₆O) a (C₂H₄O) b H (IV) wherein a is an integer such that the hydrophobe base represented by (C₃H₆O) has a molecular weight of at least about 1500 average molecular weight, as determined by hydroxyl number, or wherein a and b are integers such that the copolymer has a hydrophobe molecular weight of at least about 2000.
Claim 13
Dependent Claim
39 words
A composition according to any of claims 6 to 11, which contains at least one of a humectant, a bactericide, a bacteriostatic agent, an agent to prevent leucocyte migration into an area of surgical injury, and a fibrinolytic agent.
Claim 14
Dependent Claim
48 words
A non-aqueous composition according to any of claims 1 to 5, which comprises the block copolymer or the block copolymer and at least one of a humectant, a bactericide, a bacteriostatic agent, an agent to prevent leucocyte migration into an area of surgical injury, and a fibrinolytic agent.
Claim 15
Dependent Claim
25 words
A composition according to claim 13, wherein the polyoxyalkylene moiety is derived from an alkylene oxide selected from butylene oxide, propylene oxide, and mixtures thereof.
Claim 16
Dependent Claim
27 words
A composition according to claim 13 or 14, wherein the composition includes a physiologically acceptable non-aqueous carrier in an amount sufficient to solubilize or disperse the copolymer.
Claim 17
Dependent Claim
41 words
A composition according to claim 15, wherein the copolymer is selected from block copolymers which have a total average molecular weight of at least about 10,000 and which form aqueous gels at a concentration of about 10 to 40% by weight.
Claim 18
Dependent Claim
39 words
A composition according to claim 16, wherein the copolymer is a polyoxyethylene-polyoxypropylene block copolymer wherein the average molecular weight of A is at least about 1200, and the total molecular weight of the copolymer is at least about 10,000.
Claim 19
Dependent Claim
44 words
A composition according to claim 17, wherein intermediate of Formula II is prepared by initiation with propylene glycol, has a molecular weight of at least about 1500, and the composition contains a humectant selected from at least one of propylene glycol, glycerine, and sorbitol.
Claim 20
Dependent Claim
111 words
A composition according to any of claims 13 to 16, wherein the copolymer has the formula: HO(C₂H₄O) b (C₄H₈O) a (C₂H₄O) b H (III) wherein a is an integer such that the hydrophobe base represented by (C₄H₈O) has a molecular weight of at least about 500 as determined by hydroxyl number, or HO(C₂H₄O) b (C₃H₆O) a (C₂H₄O) b H (IV) wherein a is an integer such that the hydrophobe base represnted by (C₃H₆O) has a molecular weight of at least about 900 average molecular weight, as determined by hydroxyl number, or wherein a and b are integers such that the copolymer has a hydrophobe molecular weight of at least about 800.
Claim 21
Dependent Claim
44 words
An aqueous composition according to any of claims 1 to 5, which comprises the block copolymer and at least one of a humectant, a bactericide, a bacteriostatic agent, an agent to prevent leucocyte migration into an area of surgical injury, and a fibrinolytic agent.
Claim 22
Dependent Claim
25 words
A composition according to claim 20, wherein the polyoxyalkylene moiety is derived from an alkylene oxide selected from butylene oxide, propylene oxide, and mixtures thereof.
Claim 23
Dependent Claim
27 words
A composition according to claim 20 or 21 wherein the composition includes a physiologically acceptable non-aqueous carrier in an amount sufficient to solubilize or disperse said copolymer.
Claim 24
Dependent Claim
42 words
A composition according to claim 22, wherein the humectant is present in the amount of about 0.5% to about 10% by weight of the total weight of the composition and is selected from at least one of propylene glycol, glycerin, and sorbitol.
Claim 25
Dependent Claim
39 words
A composition according to claim 23 wherein the copolymer is a polyoxyethylene-polyoxypropylene block copolymer wherein the average molecular weight of A is at least about 1200, and the total molecular weight of the copolymer is at least about 10,000.
Claim 26
Dependent Claim
35 words
A composition according to claim 24, wherein the intermediate of Formula II is prepared by initiation with propylene glycol and has a molecular weight of at least about 1500, and the humectant is propylene glycol.
Claim 27
Dependent Claim
149 words
A composition according to any of claims 20 to 25 wherein the copolymer has the formula: HO(C₂H₄O) b (C₄H₈O) a C₂H₄O) b H (III) wherein a is an integer such that the hydrophobe base representfed by (C₄H₈O) has a molecular weight of at least about 500 as determined by hydroxyl number and the copolymer has a total average molecular weight of at least 15,000, or HO(C₂H₄O) b (C₃H₆O) a (C₂H₄O)) b H (IV) wherein a is an integer such that the hydrophobe base represented by (C₃H₆O) has a molecular weight of at least about 900 average molecular weight, as determined by hydroxyl number and the copolymer has a total average molecular weight of at least about 15,000 or wherein a and b are integers such that the copolymer has a hydrophobe molecular weight of at least about 1500 and a total average molecular weight of at least about 15,000.
Claim 28
Dependent Claim
35 words
A composition according to any of claims 1 to 26, wherein the polyoxyalkylene block copolymer is present in the amount of about 10 to about 40% by weight of the total weight of the composition.
Claim 29
Dependent Claim
27 words
A composition according to claim 27, wherein the polyoxyalkylene block copolymer is present in the amount of about 15 to about 30% by weight in the composition.
Claim 30
Dependent Claim
47 words
The use of a composition as defined in any of claims 1 to 28 for the manufacture of a medicament for the treatment of the human or animal body by reducing post-surgical adhesion formation/reformation following surgical injury to mammalian peritoneal or pleural cavity tissue or organs-situated therein.
References Cited (Backward Citations)
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