Patent EP0356614A2 successfully refreshed from Google Patents.
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EP0356614A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Hinged dermal applicator

Assignee: Mylan Technologies Inc
•
Filing: 1989-04-06
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Granted: —
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Expires: 2009-04-06
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Abstract

Abstract Devices for applying film layers and/or active agent carriers to the skin are disclosed, including a liner layer (6) having a release surface, a carrier layer (4) for the film layer (21), a first adhesive (5) between the carrier layer and the film layer, and a second adhesive (3) between the liner layer and the opposite surface of the film layer and carrier layer. In this manner, the film layer is sandwiched between the liner layer and carrier layer, and the coefficients of adhesion of the two adhesives are selected so that upon separation of the liner layer and the carrier layer the film layer remains on the carrier layer, and upon application of the film layer to the skin, the film layer transfers from the carrier layer to the skin. The device preferably includes a hinge (8) permanently connecting a peripheral edge of the carrier layer to the liner layer in order to facilitate this process, and in a preferred embodiment an active agent carrier (15) is either substituted for or added to the film layer.

Inventors

  • 👤 Alfred Kwiatek
  • 👤 John J. Wick

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-27 20:13
CPC Classifications
A; A61; A61F; A61F13/00; A61F13/02; A61F13/023; A61F2013/00361; A61F2013/00655; A61F2013/00714; A61F2013/00727; A61F2013/00761; A61F2013/00795; A61F2013/008; A61F2013/00817; A61F2013/00821; A61F2013/00829; A61F2013/00846; A61F2013/00855; A61F2013/00868; A61F2013/00902; A61F2013/00906; A61F13/0276; A61F2013/0296

Claims Analysis

Total Claims: 45
Claim 1
Independent Claim 316 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer, said carrier layer including a first surface and a second surface, said device characterized by hinge means (9) permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said film layer (2) being located on said first surface of said carrier layer at a location displaced from said hinge means, first adhesive means (5) interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said portion of said carrier layer other than said hinge means is separated from said liner layer, and second adhesive means (3) interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer, for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said film layer, said first adhesive means having a first coefficient of adhesion and said second adhesive means having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive means therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 2
Independent Claim 316 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer, said carrier layer including a first surface and a second surface, said device characterized by hinge means (9) permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said film layer (2) being located on said first surface of said carrier layer at a location displaced from said hinge means, first adhesive means (5) interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said portion of said carrier layer other than said hinge means is separated from said liner layer, and second adhesive means (3) interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer, for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said film layer, said first adhesive means having a first coefficient of adhesion and said second adhesive means having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive means therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 3
Dependent Claim 48 words
The device according to claim 1 characterized by said hinge means comprising a portion of said liner layer corresponding to said predetermined location being free of said releasable surface, and including adhesive hinge means (8a) interposed between said liner layer and said carrier layer at said predetermined location.
Claim 4
Dependent Claim 17 words
The device according to claim 1 or 2 characterized by said releasable surface comprising a siliconized coating.
Claim 5
Dependent Claim 34 words
The device according to claim 1 or 2 characterized by a portion of said first surface of said carrier layer (5a) in contact with said film layer being free of said first adhesive layer.
Claim 6
Dependent Claim 29 words
The device according to claim 1 further characterized by removal means (4) for separating said portion of said carrier layer other than said hinge means from said liner layer.
Claim 7
Dependent Claim 39 words
The device according to claim 5 characterized by said removal means comprising an extended portion of said carrier layer extending beyond the edge of said liner layer whereby said extended portion of said carrier layer can be grasped thereby.
Claim 8
Dependent Claim 35 words
The device according to claim 5 characterized by said removal means comprising slit means in said liner layer whereby said liner layer can be grasped at said slit means and separated from said carrier layer.
Claim 9
Independent Claim 289 words
A device for applying an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, said device characterized by a carrier layer (4a) for said active agent carrier (15), said carrier layer including a first surface and a second surface, said active agent carrier being located on said first surface of said carrier layer, first adhesive means (27) interposed between said first surface of said carrier layer and said active agent carrier for maintaining said active agent carrier in contact with said carrier layer when said carrier layer is separated from said liner layer, and second adhesive means (23) interposed between said first surface of said liner layer and said first surface of said carrier layer including said active agent carrier, for releasably maintaining said first surface of said carrier layer including said active agent carrier in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said active agent carrier, said first adhesive means having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said active agent carrier being less than said second coefficient of adhesion of said active agent carrier to said skin or mucosa of said patient, whereby upon application of said active agent carrier to said skin or mucosa of said patient with said second adhesive means therebetween, said active agent carrier adheres to said skin or mucosa of said patient and said active agent carrier can thereby be removed from said carrier layer.
Claim 10
Independent Claim 289 words
A device for applying an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, said device characterized by a carrier layer (4a) for said active agent carrier (15), said carrier layer including a first surface and a second surface, said active agent carrier being located on said first surface of said carrier layer, first adhesive means (27) interposed between said first surface of said carrier layer and said active agent carrier for maintaining said active agent carrier in contact with said carrier layer when said carrier layer is separated from said liner layer, and second adhesive means (23) interposed between said first surface of said liner layer and said first surface of said carrier layer including said active agent carrier, for releasably maintaining said first surface of said carrier layer including said active agent carrier in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said active agent carrier, said first adhesive means having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said active agent carrier being less than said second coefficient of adhesion of said active agent carrier to said skin or mucosa of said patient, whereby upon application of said active agent carrier to said skin or mucosa of said patient with said second adhesive means therebetween, said active agent carrier adheres to said skin or mucosa of said patient and said active agent carrier can thereby be removed from said carrier layer.
Claim 11
Dependent Claim 44 words
The device according to claim 8 further characterized by hinge means (8a) permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said active agent carrier layer displaced from said hinge means.
Claim 12
Dependent Claim 89 words
The device according to claim 8 or 9 characterized by said active agent carrier comprising a reservoir (17) containing said active agent, release means (21) for the controlled release of said active agent from said reservoir, and an active agent impermeable barrier layer (19) between said reservoir and said carrier layer, whereby said active agent may only be released from the inner surface of said reservoir towards said skin or mucosa of said patient upon application of said active agent carrier to said skin or mucosa of said patient.
Claim 13
Dependent Claim 47 words
The device according to claim 10 characterized by said release means (21) comprising an active agent permeable membrane layer formed on said inner surface of said reservoir, whereby said reservoir is completely enclosed between said active agent permeable membrane layer and said active agent impermeable barrier layer.
Claim 14
Dependent Claim 65 words
The device according to claim 11 characterized by said second adhesive means 18 including an active agent permeable adhesive portion (27) and an active agent impermeable adhesive portion (23), said active agent permeable adhesive portion corresponding to said active agent permeable membrane layer and said active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 15
Independent Claim 347 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, said device characterized by a carrier layer (4a) for said film layer (2a) and said active agent carrier (15), said carrier layer including a first surface and a second surface, said film layer including a first surface and a second surface, said first surface of said film layer being located on said first surface of said carrier layer, a first adhesive layer (27) interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said carrier layer is separated from said liner layer, said active agent carrier being located on said second surface of said film layer, and a second adhesive layer (23) interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier, for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can be simultaneously removed from said carrier layer.
Claim 16
Independent Claim 347 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, said device characterized by a carrier layer (4a) for said film layer (2a) and said active agent carrier (15), said carrier layer including a first surface and a second surface, said film layer including a first surface and a second surface, said first surface of said film layer being located on said first surface of said carrier layer, a first adhesive layer (27) interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said carrier layer is separated from said liner layer, said active agent carrier being located on said second surface of said film layer, and a second adhesive layer (23) interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier, for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can be simultaneously removed from said carrier layer.
Claim 17
Dependent Claim 44 words
The device according to claim 13 further characterized by hinge means (8a) permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said active agent carrier being displaced from said hinge means.
Claim 18
Dependent Claim 89 words
The device according to claim 13 or 14 characterized by said active agent carrier comprising a reservoir (17) containing said active agent, release means (21) for the controlled release of said active agent from said reservoir, and an active agent impermeable barrier layer (19) between said reservoir and said film layer, whereby said active agent may only be released from the inner surface of said reservoir towards said skin or mucosa of said patient upon application of said active agent carrier to said skin or mucosa of said patient.
Claim 19
Dependent Claim 46 words
The device according to claim 15 characterized by said release means comprising an active agent permeable membrane layer formed on said inner surface of said reservoir, whereby said reservoir is completely enclosed between said active agent permeable membrane layer and said active agent impermeable barrier layer.
Claim 20
Dependent Claim 64 words
The device according to claim 16 characterized by said second adhesive layer including an active agent permeable adhesive portion (27) and an active agent impermeable adhesive portion (23), said active agent permeable adhesive portion corresponding to said active agent permeable membrane layer and said active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 21
Dependent Claim 48 words
The device according to claim 17 characterized by said active agent impermeable barrier layer comprising a cover layer (18) including an inner surface and an outer surface, and characterized by said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 22
Dependent Claim 53 words
The device according to claim 15 characterized by said active agent impermeable barrier layer including an inner surface facing said reservoir, and an outer surface facing said film layer, and a backing member (19) disposed on said portion of said inner surface of said active agent impermeable barrier layer corresponding to said reservoir.
Claim 23
Dependent Claim 89 words
The device according to claim 17 characterized by said active agent permeable membrane layer extending peripherally beyond said reservoir so as to provide at least a portion of overlapping peripheral surfaces between said peripheral portion of said active agent permeable membrane layer and said peripheral portion of said active agent impermeable barrier layer, and characterized by said overlapping peripheral portions are heat sealed together to create an active agent impermeable seal surrounding said reservoir, whereby said active agent impermeable adhesive layer is applied to said active agent impermeable seal.
Claim 24
Dependent Claim 47 words
The device according to claim 20 characterized by said active agent impermeable barrier layer comprising a cover layer (18) including an outer surface and an inner surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 25
Independent Claim 378 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, said device characterized by a carrier layer (4) for said film layer, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, said film layer (2) being located on said first surface of said carrier layer, temporary closure means (34, 34a) for temporarily sealing said first surface of said liner layer to said first surface of said carrier layer at at least a portion of the corresponding outer peripheries thereof so as to provide a sealed container for said film layer therein, said temporary closure means comprising a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer, a first adhesive layer (5) interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said carrier layer is separated from said liner layer, and a second adhesive layer (3) interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said film layer in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 26
Independent Claim 378 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, said device characterized by a carrier layer (4) for said film layer, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, said film layer (2) being located on said first surface of said carrier layer, temporary closure means (34, 34a) for temporarily sealing said first surface of said liner layer to said first surface of said carrier layer at at least a portion of the corresponding outer peripheries thereof so as to provide a sealed container for said film layer therein, said temporary closure means comprising a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer, a first adhesive layer (5) interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said carrier layer is separated from said liner layer, and a second adhesive layer (3) interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said film layer in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 27
Dependent Claim 34 words
The device according to claim 22 further characterized by hinge means (8a) permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon.
Claim 28
Dependent Claim 54 words
The device according to claim 22 or 23 characterized by said first surface of said liner layer comprising a first polymer layer and said first surface of said carrier layer comprises a second polymer layer, and wherein said first and second polymer layers comprise different polymers whereby said peelable heat seal is formed therebetween.
Claim 29
Dependent Claim 60 words
The device according to claim 22 or 23 characterized by said first surface of said liner layer comprising a first polymer layer (32a), said second surface of said liner layer comprising a paper layer (30a), and said liner layer including an intermediate layer (32a) between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 30
Dependent Claim 58 words
The device according to claim 25 characterized by said first surface of said carrier layer comprising a first polymer layer (34), said second surface of said carrier layer comprising a paper layer (30), and said carrier layer including an intermediate layer (32) between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 31
Dependent Claim 34 words
The device according to claim 26 characterized by said temporary closure means comprising a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer.
Claim 32
Independent Claim 420 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, said device characterized by a carrier layer (4a) for said film layer (2a) and said active agent carrier (15), said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, said film layer (2a) including a first surface and a second surface, and said first surface of said film layer being located on said first surface of said carrier layer, temporary closure means (34, 34a) for temporarily sealing said first surface of said liner layer to said first surface of said liner layer to said first surface of said carrier layer at at least a portion of said corresponding outer peripheries thereof, so as to provide a sealed container for said film layer and said active agent carrier therein, a first adhesive layer (27) interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said portion of said carrier layer other than said hinge means is separated from said liner layer, and a second adhesive layer (23) interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can simultaneously be removed from said carrier layer.
Claim 33
Independent Claim 420 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, said device characterized by a carrier layer (4a) for said film layer (2a) and said active agent carrier (15), said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, said film layer (2a) including a first surface and a second surface, and said first surface of said film layer being located on said first surface of said carrier layer, temporary closure means (34, 34a) for temporarily sealing said first surface of said liner layer to said first surface of said liner layer to said first surface of said carrier layer at at least a portion of said corresponding outer peripheries thereof, so as to provide a sealed container for said film layer and said active agent carrier therein, a first adhesive layer (27) interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said portion of said carrier layer other than said hinge means is separated from said liner layer, and a second adhesive layer (23) interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can simultaneously be removed from said carrier layer.
Claim 34
Dependent Claim 34 words
The device according to claim 28 further characterized by hinge means (8a) permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon.
Claim 35
Dependent Claim 93 words
The device according to claim 28 or 29 characterized by said active agent carrier comprising a reservoir (17) containing said active agent, release means (21) for the controlled release of said active agent from said reservoir, and an active agent impermeable barrier layer (19) between said reservoir and said film layer, whereby said active agent may only be released from the inner surface of said reservoir towards said skin or mucosa of said patient upon application of said film layer and said active agent carrier to said skin or mucosa of said patient.
Claim 36
Dependent Claim 46 words
The device according to claim 30 characterized by said release means comprising an active agent permeable membrane layer formed on said inner surface of said reservoir, whereby said reservoir is completely enclosed between said active agent permeable membrane layer and said active agent impermeable barrier layer.
Claim 37
Dependent Claim 64 words
The device according to claim 31 characterized by said second adhesive layer including an active agent permeable adhesive portion (27) and an active agent impermeable adhesive portion (23), said active agent permeable adhesive portion corresponding to said active agent permeable membrane layer and said active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 38
Dependent Claim 47 words
The device according to claim 32 characterized by said active agent impermeable barrier layer comprising a cover layer (18) including an inner surface and an outer surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 39
Dependent Claim 90 words
The device according to claim 28 or 29 characterized by said active agent permeable membrane layer extending peripherally beyond said reservoir so as to provide at least a portion of overlapping peripheral surfaces between said peripheral portion of said active agent permeable membrane layer and said peripheral portion of said active agent impermeable barrier layer, and wherein said overlapping peripheral portions are heat sealed together to create an active agent impermeable seal surrounding said reservoir, whereby said active agent impermeable adhesive layer is applied to said active agent impermeable seal.
Claim 40
Dependent Claim 47 words
The device according to claim 34 characterized by said active agent impermeable barrier layer comprising a cover layer (18) including an outer surface and an inner surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 41
Dependent Claim 38 words
The device according to claim 28 or 29 characterized by said temporary closure means (34, 34a) comprising a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer.
Claim 42
Dependent Claim 54 words
The device according to claim 36 characterized by said first surface of said liner layer comprising a first polymer layer (32a) and said first surface of said carrier layer comprises a second polymer layer (32), and wherein said first and second polymer layers comprise different polymers whereby said peelable heat seal is formed therebetween.
Claim 43
Dependent Claim 60 words
The device according to claim 28 or 29 characterized by said first surface of said liner layer comprising a first polymer layer (32a), said second surface of said liner layer comprising a paper layer (30a), and said liner layer including an intermediate layer (32a) between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 44
Dependent Claim 58 words
The device according to claim 38 characterized by said first surface of said carrier layer comprising a first polymer layer (34), said second surface of said carrier layer comprising a paper layer (30), and said carrier layer including an intermediate layer (32) between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 45
Dependent Claim 34 words
The device according to claim 39 characterized by said temporary closure means comprising a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer.

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