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EP0356399A2
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Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them
Assignee: Novartis Pharma GmbH
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Filing: 1989-08-22
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Granted: —
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Expires: 2009-08-22
Abstract
Abstract The compounds of formula I wherein either R₁ is hydroxy, R₂ is allyl or n-propyl and there is a single bond between the carbon atoms numbered 14 and 15 or R₁ is missing, R₂ is allyl and there is a double bond between the carbon atoms numbered 14 and 15, have interesting immunosuppressant and anti-inflammatory properties. They are obtained by fermentation or synthesis, e.g. by hydrogenation or dehydration.
Inventors
- 👤 Theodor Fehr
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 11:29
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/02; C07H15/04; A; A61; A61P; A61P17/00; A61P27/00; A61P27/02; A61P29/00; A61P37/00; A61P37/02; A61P37/06; C12; C12P; C12P19/00; C12P19/44; C12P19/445; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/898
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
127 words
A process for the preparation of a compound of formula I wherein either R₁ is hydroxy, R₂ is allyl or n-propyl and there is a single bond between the carbon atoms numbered 14 and 15 or R₁ is missing, R₂ is allyl and there is a double bond between the carbon atoms numbered 14 and 15 which comprises a) for the preparation of the compounds of formula I wherein R₁ is hydroxy or missing and R₂ is allyl, cultivating an appropriate Streptomyces strain such as Streptomyces tsukubaensis No. 9993 and isolating the compounds from the resultant culture or b) for the preparation of the compound of formula I wherein R₁ is missing and R₂ is allyl, dehydrating the corresponding compound of formula I wherein R₁ is hydroxy.
Claim 2
Dependent Claim
127 words
A process for the preparation of a compound of formula I wherein either R₁ is hydroxy, R₂ is allyl or n-propyl and there is a single bond between the carbon atoms numbered 14 and 15 or R₁ is missing, R₂ is allyl and there is a double bond between the carbon atoms numbered 14 and 15 which comprises a) for the preparation of the compounds of formula I wherein R₁ is hydroxy or missing and R₂ is allyl, cultivating an appropriate Streptomyces strain such as Streptomyces tsukubaensis No. 9993 and isolating the compounds from the resultant culture or b) for the preparation of the compound of formula I wherein R₁ is missing and R₂ is allyl, dehydrating the corresponding compound of formula I wherein R₁ is hydroxy.
Claim 3
Dependent Claim
50 words
A process for the preparation of the compound of formula I as defined in claim 1 wherein R₁ is hydroxy, R₂ is n-propyl and there is a single bond between the carbon atoms numbered 14 and 15 which comprises hydrogenating the corresponding compound of formula I wherein R₂ is allyl.
Claim 4
Dependent Claim
37 words
A process according to claim 1 for the preparation of the compound according to claim 1 wherein R₁ is hydroxy, R₂ is allyl and there is a single bond between the carbon atoms numbered 14 and 15.
Claim 5
Dependent Claim
61 words
A process according to claim 1 or 2 for the preparation of the compounds according to claim 1 wherein either R₁ is hydroxy, R₂ is n-propyl and there is a single bond between the carbon atoms numbered 14 and 15 or R₁ is missing, R₂ is allyl and there is a double bond between the carbon atoms numbered 14 and 15.
Claim 6
Dependent Claim
28 words
A process for the preparation of a pharmaceutical composition comprising mixing a compound of formula I as defined in claim 1 with a pharmaceutically acceptable carrier or diluent.
References Cited (Backward Citations)
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