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EP0352249A1
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Novel platelet-aggregation inhibitors
Assignee: Monsanto Co
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Filing: 1989-07-19
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Granted: —
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Expires: 2009-07-19
Abstract
Abstract Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure wherein x = 6 to 10, y = 0 to 4, Z = H, COOH, CONH₂ or Cl-6 alkyl, Ar = phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, and Asp = aspartic acid residue.
Inventors
- 👤 Foe Siong Tjoeng
- 👤 Steven Paul Adams
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 13:13
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06104; C07K5/06113; A; A61; A61P; A61P7/00; A61P7/02; C07C; C07C279/00; C07C279/04; C07C279/14; C07K5/02; C07K5/021
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
58 words
A peptide mimetic compound having the following chemical structure: wherein x = 6 to 10, y = 0 to 4, Z = H, COOH, CONH₂ or C₁₋₆ alkyl, Ar = phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, and Asp = aspartic acid residue.
Claim 2
Dependent Claim
58 words
A peptide mimetic compound having the following chemical structure: wherein x = 6 to 10, y = 0 to 4, Z = H, COOH, CONH₂ or C₁₋₆ alkyl, Ar = phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, and Asp = aspartic acid residue.
Claim 3
Dependent Claim
2 words
8-guanidino-octanoyl-Asp-2-(4-methoxyphenyl)-ethyl amide.
Claim 4
Dependent Claim
2 words
8-guanidino-octanoyl-Asp-2-(4-methoxyphenyl)-ethyl amide.
Claim 5
Dependent Claim
2 words
8-guanidino-octanoyl-Asp-2-(3,4-dimethoxyphenyl)-ethyl amide.
Claim 6
Dependent Claim
2 words
8-guanidino-octanoyl-Asp-2-(3,4-dimethoxyphenyl)-ethyl amide.
Claim 7
Dependent Claim
2 words
8-guanidino-octanoyl-Asp-4-methoxybenzyl amide.
Claim 8
Dependent Claim
2 words
8-guanidino-octanoyl-Asp-4-methoxybenzyl amide.
Claim 9
Dependent Claim
2 words
8-guanidino-octanoyl-Asp-(4-phenyl)-phenylalanine amide.
Claim 10
Dependent Claim
2 words
8-guanidino-octanoyl-Asp-(4-phenyl)-phenylalanine amide.
Claim 11
Dependent Claim
2 words
9-guanidino-nonanoyl-Asp-2-(4-methoxyphenyl)-ethyl amide.
Claim 12
Dependent Claim
2 words
9-guanidino-nonanoyl-Asp-2-(4-methoxyphenyl)-ethyl amide.
Claim 13
Dependent Claim
2 words
10-guanidino-decanoyl-Asp-2-(4-methoxyphenyl)-ethyl amide.
Claim 14
Dependent Claim
2 words
10-guanidino-decanoyl-Asp-2-(4-methoxyphenyl)-ethyl amide.
Claim 15
Dependent Claim
2 words
7-guanidino-heptanoyl-Asp-2-(4-methoxyphenyl)-ethyl amide.
Claim 16
Dependent Claim
2 words
7-guanidino-heptanoyl-Asp-2-(4-methoxyphenyl)-ethyl amide.
Claim 17
Dependent Claim
32 words
The method of inhibiting platelet aggregation in a warm blooded mammal comprising administering to said mammal an effective amount of the peptide mimetic compound of Claim 1 in a pharmaceutically acceptable carrier.
Claim 18
Dependent Claim
34 words
The method of inhibiting formation of a thrombus in a warm blooded mammal comprising administering to said mammal an effective amount of the peptide mimetic compound of Claim 1 in a pharmaceutically acceptable carrier.
Claim 19
Dependent Claim
12 words
The peptide mimetic compound of Claim 1 in a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
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