Patent EP0347028A2 successfully refreshed from Google Patents.
EP0347028A2
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Calcium phosphate mineral compositions and methods for preparing same
Assignee: Norian Corp
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Filing: 1989-04-18
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Granted: —
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Expires: 2009-04-18
Abstract
Abstract Calcium phosphate minerals are formed by using phosphoric acid substantially free of uncombined water in conjunction with a calcium source, normally as any combination of carbonate, phosphate and hydroxide, and, as required, any additional base to neutralize the phosphoric acid. Protein may be optionally added. The resulting product is readily formed and then sets to a hard, stable, workable shaped object.
Inventors
- 👤 Brent R. Constantz
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 11:56
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/02; A61K; A61K6/00; A61K6/30; A61K6/50; A61K6/54; A61K6/70; A61K6/71; A61K6/74; A61K6/75; A61K6/80; A61K6/831; A61K6/838; A61K6/849; A61K6/864; A61K6/873; A61K6/876; A61L27/00; A61L27/02; A61L27/12; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/58; C; C01; C01B; C01B25/00; C01B25/16; C01B25/26; C01B25/32; C01B25/322; C01B25/327; C01B25/455; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2002/2817; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2210/00; A61F2210/0004; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
60 words
A method for making calcium phosphate minerals comprising: combining phosphoric acid substantially free of uncombined water, a calcium source, neutralizing anions including at least one of carbonate, phosphate and hydroxide in an amount sufficient to substantially neutralise said phosphoric acid and water in an amount to provide a kneadable product; and agitating the mixture to produce a substantially uniform mixture.
Claim 2
Independent Claim
60 words
A method for making calcium phosphate minerals comprising: combining phosphoric acid substantially free of uncombined water, a calcium source, neutralizing anions including at least one of carbonate, phosphate and hydroxide in an amount sufficient to substantially neutralise said phosphoric acid and water in an amount to provide a kneadable product; and agitating the mixture to produce a substantially uniform mixture.
Claim 3
Dependent Claim
14 words
A method according to claim 1, wherein said phosphoric acid is orthophosphoric acid crystals.
Claim 4
Dependent Claim
40 words
A method according to claim 2, wherein the dry ingredients, orthophosphoric acid and calcium source are premixed prior to combining with the other wet ingredients or the calcium source and water are precombined prior to combining with said phosphoric acid.
Claim 5
Independent Claim
24 words
A method according to any one of claims 1 to 3, wherein said calcium source is present at least in part as calcium carbonate.
Claim 6
Independent Claim
57 words
A method for making hydroxyapatite comprising: combining orthophosphoric acid crystals, a neutralizing source comprising at least one of calcium carbonate, alkali metal hydroxide, calcium hydroxide or calcium phosphate, in an amount to provide a substantially neutral product, and water in an amount to provide a kneadable mixture; and agitating the mixture to produce a substantially uniform mixture.
Claim 7
Independent Claim
57 words
A method for making hydroxyapatite comprising: combining orthophosphoric acid crystals, a neutralizing source comprising at least one of calcium carbonate, alkali metal hydroxide, calcium hydroxide or calcium phosphate, in an amount to provide a substantially neutral product, and water in an amount to provide a kneadable mixture; and agitating the mixture to produce a substantially uniform mixture.
Claim 8
Dependent Claim
20 words
A method according to claim 5, wherein said orthophosphoric acid crystals and neutralizing source are precombined in a uniform mixture.
Claim 9
Dependent Claim
34 words
A method according to claim 5 or claim 6, wherein said orthophosphoric acid crystals are present in 6-15 parts by weight, and said calcium carbonate is present in from about 6-15 parts by weight.
Claim 10
Independent Claim
34 words
A method according to any one of claims 5 to 8, wherein a source of fluoride or chloride is included in said mixture to displace at least 10% of the hydroxyl groups of hydroxyapatite.
Claim 11
Independent Claim
45 words
A method according to any one of claims 5 to 8, wherein dilute HF or HCl are included with a carbonate anion calcium source, wherein said HF or HCl are in sufficient amount to displace at least 10% of the hydroxyl groups of said hydroxyapatite.
Claim 12
Independent Claim
20 words
A method according to any one of claims 1 to 9, wherein a protein is combined in said combining step.
Claim 13
Dependent Claim
17 words
A method according to claim 10, wherein 0.2-2 parts of collagen is combined in said combining step.
Claim 14
Independent Claim
29 words
A method according to any one of the preceding claims, which further comprises the step of allowing the mixture to set and become. annealed to a hard workable structure.
Claim 15
Dependent Claim
22 words
A formed object of a calcium phosphate or of an hydroxyapatite prepared in accordance with any one of claims 1 to 12.
Claim 16
Dependent Claim
25 words
A formed object having a coating of a calcium phosphate or of an hydroxyapatite prepared in accordance with any one of claims 1 to 12.
References Cited (Backward Citations)
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