Patent EP0341007B1 successfully refreshed from Google Patents.
EP0341007B1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Surgical adhesive material
Assignee: MATRIX PHARMACEUTICAL INC;COHESION CORPORATION
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Filing: 1989-04-28
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Granted: 1994-09-14
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Expires: 2009-04-28
Abstract
Abstract The present invention provides a surgical adhesive comprising, in an aqueous composition, patient autogenous plasma, collagen, thrombin, and optionally, an antifibrinolytic agent. The present adhesive is formed from the patient's plasma without the use of any added reagents for concentration or isolation of the fibrinogen. Conveniently, the adhesive is formulated as a two-part composition which is mixed together just prior to use.
Inventors
- 👤 David H. Sierra
- 👤 Edward E. Luck
- 👤 Dennis M. Brown
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:10
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L24/0005; A61L24/0047; A61L24/0073; A61L24/0084
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
61 words
A surgical adhesive useful in treating a patient comprising in an aqueous composition: (a) plasma from said patient; (b) collagen at at least 5mg/ml and in an amount which is greater than the amount of fibrinogen in the composition and sufficient to thicken said composition; and (c) thrombin to catalyze polymerization of fibrinogen present in said plasma to produce a clot.
Claim 2
Dependent Claim
36 words
A surgical adhesive useful in treating a patient comprising in an aqueous composition: (a) plasma from said patient; (b) collagen in a concentration of from 5mg/ml to 30mg/ml; and (c) from 1 to 1000 NIHu thrombin.
Claim 3
Dependent Claim
19 words
The surgical adhesive according to claim 1 or claim 2 wherein said collagen concentration is from 10mg/ml to 20mg/ml.
Claim 4
Dependent Claim
17 words
The surgical adhesive according to claim 1, claim 2 or claim 3 additionally comprising an anti-fibrinolytic agent.
Claim 5
Dependent Claim
16 words
The surgical adhesive according to any one of the preceding claims additionally comprising an antimicrobial agent.
Claim 6
Dependent Claim
16 words
The surgical adhesive according to any one of the preceding claims additionally comprising an inorganic mineral.
Claim 7
Dependent Claim
12 words
The surgical adhesive according to claim 6 wherein said mineral is hydroxyapatite.
Claim 8
Dependent Claim
19 words
The surgical adhesive according to claim 6 wherein said inorganic mineral is provided by bone powder or bone chips.
Claim 9
Dependent Claim
17 words
The surgical adhesive according to any one of the preceding claims additionally comprising osteoblasts from said patient.
Claim 10
Independent Claim
86 words
A method of making a surgical adhesive for treating a patient comprising: (a) mixing plasma from said patient with collagen in an amount of at least 5mg/ml, said amount being sufficient to thicken said plasma to form a thickened composition and being greater than the amount of fibrinogen in the composition; (b) combining said thickened composition with thrombin to catalyze polymerization of fibrinogen present in said plasma and optionally an effective amount of an antifibrinolytic agent, whereby said fibrinogen is polymerized to form said surgical adhesive.
Claim 11
Dependent Claim
19 words
The method according to claim 10 wherein thrombin is present in a concentration of from 100 to 500 NIHu/ml.
Claim 12
Dependent Claim
22 words
A kit comprising in a first container flowable, dispersable collagen and in a second container, thrombin, optionally admixed with an antifibrinolytic agent.
References Cited (Backward Citations)
No citation records indexed.
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