Patent EP0321145A2 successfully refreshed from Google Patents.
EP0321145A2
Expired / Lapsed
EP
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Immunodiagnostic device
Assignee: Pall Corp
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Filing: 1988-12-08
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Granted: —
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Expires: 2008-12-08
Abstract
Abstract A flow enhanced immunodiagnostic device is provided comprising a hollow elongate member having first and second openings and a porous liquophilic membrane positioned across the first opening. The porous liquophilic membrane may also contain a test reagent or an activating agent capable of reacting with a test reagent which itself is capable of reacting with a predetermined analyte and producing an indicia of the presence of the analyte, the second opening being adapted to be operatively associated with means for generating a pressure differential between the interior of the elongate member and the exterior thereof, whereby a liquid test sample containing an analyte may be introduced into the interior of the elongate member by passing through the first opening and the porous hydrophilic membrane and any insoluble substances present in the liquid test sample accumulates on a surface of the porous liquophilic membrane.
Inventors
- 👤 Frank Richard Pascale
- 👤 Malcolm James Latham
- 👤 Vlado Ivan Matkovich
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 10:23
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54366
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
106 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having first and second openings; and a porous liquophilic membrane positioned across said first opening, said porous liquophilic membrane containing an activating agent capable of reacting with a test reagent, said second opening adapted to be operatively associated with means for generating a pressure differential between the interior of said elongate member and the exterior thereof, whereby a liquid test sample may be introduced to the interior of said elongate member bypassing through said porous liquophilic membrane and any insoluble substances present in said liquid test sample accumulates on a surface of said porous liquophilic membrane.
Claim 2
Dependent Claim
106 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having first and second openings; and a porous liquophilic membrane positioned across said first opening, said porous liquophilic membrane containing an activating agent capable of reacting with a test reagent, said second opening adapted to be operatively associated with means for generating a pressure differential between the interior of said elongate member and the exterior thereof, whereby a liquid test sample may be introduced to the interior of said elongate member bypassing through said porous liquophilic membrane and any insoluble substances present in said liquid test sample accumulates on a surface of said porous liquophilic membrane.
Claim 3
Dependent Claim
21 words
A flow enhanced immunodiagnostic device according to claim 1 wherein said activating agent is covalently bound to said porous liquophilic membrane.
Claim 4
Dependent Claim
27 words
A flow enhanced immunodiagnostic device according to claim 1 wherein said porous membrane comprises a hydrophilic, microporous, skinless, polyamide membrane chemically bound to a residue of trichloro-s-triazine.
Claim 5
Dependent Claim
122 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having at least first and second openings; a porous liquophilic membrane positioned across said first opening and containing an activating agent capable of reacting with a test reagent; and means associated with said second opening for permitting ingress of liquid into said elongate member through said second opening while retarding egress of liquid from said elongate member through said second opening, whereby a liquid test sample maybe introduced to the interior of said elongate member through said ingress means and liquid is expelled from said reservoir exclusively through said porous liquophilic membrane while any insoluble substance present in said liquid test sample accumulates on an inner surface of said porous liquophilic membrane.
Claim 6
Dependent Claim
122 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having at least first and second openings; a porous liquophilic membrane positioned across said first opening and containing an activating agent capable of reacting with a test reagent; and means associated with said second opening for permitting ingress of liquid into said elongate member through said second opening while retarding egress of liquid from said elongate member through said second opening, whereby a liquid test sample maybe introduced to the interior of said elongate member through said ingress means and liquid is expelled from said reservoir exclusively through said porous liquophilic membrane while any insoluble substance present in said liquid test sample accumulates on an inner surface of said porous liquophilic membrane.
Claim 7
Dependent Claim
41 words
A flow enhanced immunodiagnostic device according to claim 4 wherein said hollow elongate member has a third opening adapted to be operatively associated with means for generating a pressure differential between the interior of said elongate member and the exterior thereof.
Claim 8
Dependent Claim
91 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having first and second openings; and a porous liquophilic membrane positioned across said first opening, said second opening adapted to be operatively associated with means for generating a pressure differential between the interior of said elongate member and the exterior thereof, whereby a liquid test sample may be introduced into the interior of said elongate member bypassing through said porous hydrophilic membrane and any insoluble substances present in said liquid test sample accumulates on a surface of said porous liquophilic membrane.
Claim 9
Dependent Claim
91 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having first and second openings; and a porous liquophilic membrane positioned across said first opening, said second opening adapted to be operatively associated with means for generating a pressure differential between the interior of said elongate member and the exterior thereof, whereby a liquid test sample may be introduced into the interior of said elongate member bypassing through said porous hydrophilic membrane and any insoluble substances present in said liquid test sample accumulates on a surface of said porous liquophilic membrane.
Claim 10
Dependent Claim
110 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having at least first and second openings; a porous liquophilic membrane positioned across said first opening; and means associated with said second opening for permitting ingress of liquid into said elongate member through said second opening while retarding egress of liquid from said elongate member through said second opening, whereby a liquid test sample maybe introduced to the interior of said elongate member through said ingress means and liquid is expelled from said reservoir exclusively through said porous liquophilic membrane while any insoluble substance present in said liquid test sample accumulates on an inner surface of said porous liquophilic membrane.
Claim 11
Dependent Claim
110 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having at least first and second openings; a porous liquophilic membrane positioned across said first opening; and means associated with said second opening for permitting ingress of liquid into said elongate member through said second opening while retarding egress of liquid from said elongate member through said second opening, whereby a liquid test sample maybe introduced to the interior of said elongate member through said ingress means and liquid is expelled from said reservoir exclusively through said porous liquophilic membrane while any insoluble substance present in said liquid test sample accumulates on an inner surface of said porous liquophilic membrane.
Claim 12
Dependent Claim
41 words
A flow enhanced immunodiagnostic device according to claim 7 wherein said hollow elongate member has a third opening and means associated with said third opening for generating a pressure differential between the interior of said elongate member and the exterior thereof.
Claim 13
Dependent Claim
125 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having first and second openings; and a porous liquophilic membrane positioned across said first opening, said porous liquophilic membrane containing a test reagent capable of reacting with an analyte and producing an indicia of the presence of the analyte, said second opening adapted to be operatively associated with means for generating a pressure differential between the interior of said elongate member and the exterior thereof, whereby a liquid test sample containing a substantially soluble analyte may be introduced into the interior of said elongate member by passing through said first opening and said porous liquophilic membrane and any insoluble substances present in said liquid test sample accumulates on a surface of said porous liquophilic membrane.
Claim 14
Dependent Claim
125 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having first and second openings; and a porous liquophilic membrane positioned across said first opening, said porous liquophilic membrane containing a test reagent capable of reacting with an analyte and producing an indicia of the presence of the analyte, said second opening adapted to be operatively associated with means for generating a pressure differential between the interior of said elongate member and the exterior thereof, whereby a liquid test sample containing a substantially soluble analyte may be introduced into the interior of said elongate member by passing through said first opening and said porous liquophilic membrane and any insoluble substances present in said liquid test sample accumulates on a surface of said porous liquophilic membrane.
Claim 15
Dependent Claim
39 words
A flow enhanced immunodiagnostic device according to claim 9 wherein said porous membrane comprises a hydrophilic, microporous, skinless, polyamide membrane chemically bound to a residue of an activating agent, which residue is also bound to a biologically active material.
Claim 16
Dependent Claim
33 words
A flow enhanced immunodiagnostic device according to claim 9 wherein said means for generating a pressure differential comprises a piston having a shape commensurate with the internal configuration of the hollow elongate member.
Claim 17
Dependent Claim
21 words
A flow enhanced immunodiagnostic device according to claim 9 wherein said means for generating a pressure differential comprises an elastomeric bulb.
Claim 18
Dependent Claim
143 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having at least first and second openings; a porous liquophilic membrane containing a test reagent capable of reacting with a predetermined analyte and producing an indicia of the presence of the analyte, said liquophilic membrane positioned across said first opening; and means associated with said second opening for permitting ingress of liquid into said elongate member through said second opening while retarding egress of liquid from said elongate member through said second opening, whereby a liquid test sample containing an analyte may be introduced to the interior of said elongate member through said ingress means and liquid is expelled from said elongate member exclusively through said porous liquophilic membrane and said first opening while any insoluble substance present in said liquid test sample accumulates on an inner surface of said porous liquophilic membrane.
Claim 19
Dependent Claim
143 words
A flow enhanced immunodiagnostic device comprising: a hollow elongate member having at least first and second openings; a porous liquophilic membrane containing a test reagent capable of reacting with a predetermined analyte and producing an indicia of the presence of the analyte, said liquophilic membrane positioned across said first opening; and means associated with said second opening for permitting ingress of liquid into said elongate member through said second opening while retarding egress of liquid from said elongate member through said second opening, whereby a liquid test sample containing an analyte may be introduced to the interior of said elongate member through said ingress means and liquid is expelled from said elongate member exclusively through said porous liquophilic membrane and said first opening while any insoluble substance present in said liquid test sample accumulates on an inner surface of said porous liquophilic membrane.
Claim 20
Dependent Claim
41 words
A flow enhanced immunodiagnostic device according to claim 13 wherein said hollow elongate member has a third opening and means associated with said third opening for generating a pressure differential between the interior of said elongate member and the exterior thereof.
Claim 21
Dependent Claim
27 words
A flow enhanced immunodiagnostic device according to any of claims 1, 4, 6, 7, 9, or 13 wherein the porous liquophilic membrane is a microporous hydrophilic membrane.
Claim 22
Dependent Claim
22 words
A flow enhanced immunodiagnostic device according to any of claims 9 or 13 wherein said test reagent comprises a biologically active material.
Claim 23
Dependent Claim
25 words
A flow enhanced immunodiagnostic device according to any of claims 1, 4, 6, 7, 9, or 13 wherein said porous membrane comprises a polyamide membrane.
References Cited (Backward Citations)
No citation records indexed.
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