Patent EP0285441A2 successfully refreshed from Google Patents.
EP0285441A2
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Synergistic immunostimulating composition and method
Assignee: Mallinckrodt Inc
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Filing: 1988-03-31
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Granted: —
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Expires: 2008-03-31
Abstract
Abstract The known immunostimulants FK-565 and IL-2 are administered to animals in conjunction to synergistically stimulate the immune system.
Inventors
- 👤 David K. Howard
- 👤 Anthony F. Dr. Abruzzini
- 👤 Ellen R. Dr. Clough
- 👤 Paula Dr. Myers-Keith
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 03:46
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/39; A23; A23K; A23K20/00; A23K20/10; A23K20/142; A23K20/147; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/20; A61K38/2013; A61P; A61P37/00; A61P37/02; A61P37/04; A61K2039/555; A61K2039/55511; A61K2039/55516; A61K2039/55522; A61K2039/55527; A61K2039/55533; Y; Y10; Y10S; Y10S435/00; Y10S435/81
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
25 words
An immunostimulating composition suitable for synergistically stimulating an animal's immune system or functioning as an adjuvant, which comprises: IL-2, FK-565, and a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
25 words
An immunostimulating composition suitable for synergistically stimulating an animal's immune system or functioning as an adjuvant, which comprises: IL-2, FK-565, and a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
28 words
A composition containing FK-565 and IL-2 as a combined preparation for simultaneous, separate or sequential use for synergistically stimulating an animal's immune system or functioning as an adjuvant.
Claim 4
Dependent Claim
28 words
A composition containing FK-565 and IL-2 as a combined preparation for simultaneous, separate or sequential use for synergistically stimulating an animal's immune system or functioning as an adjuvant.
Claim 5
Dependent Claim
39 words
The composition of claim 1 or claim 2 in the form of dosage units each containing FK-565 in amounts from about 0.001 to about 1000 µg/kg body weight and IL-2 in amounts from about 10¹ to about 10⁸ units.
Claim 6
Dependent Claim
32 words
The composition of claim 1 or claim 2 containing FK-565 in amounts from about 0.01 to about 10 µg/kg body weight and IL-2 in amounts from about 10² to about 10⁷ units.
Claim 7
Dependent Claim
27 words
The composition of claim 2 wherein FK-565 is provided in a form adapted from oral administration and IL-2 is provided in a form adapted for parenteral administration.
Claim 8
Dependent Claim
30 words
The composition of claim 5 wherein said oral administration form is selected from the group consisting of tablets, suspensions, solutions, emulsions, capsules, powders, syrups, drinking water compositions, and feed compositions.
Claim 9
Dependent Claim
36 words
The composition of claim 5 or claim 6 wherein FK-565 is administered in a feed composition, said feed composition further comprising: a nutritionally balanced feed; and an immune stimulating amount of FK-565 admixed with said feed.
Claim 10
Dependent Claim
27 words
The composition of claim 2 wherein FK-565 is provided in a form adapted for nasal administration and IL-2 is provided in a form adapted for parenteral administration.
Claim 11
Dependent Claim
21 words
The composition of claim 1 or claim 2 wherein FK-565 and IL-2 are provided in a form adapted for parenteral administration.
Claim 12
Dependent Claim
35 words
The composition of claim 1 or claim 2 in the form of an implant, said implant comprising: a biocompatible and FK-565 and IL-2 compatible implant material; and an immune stimulating amount of FK-565 and IL-2.
Claim 13
Dependent Claim
43 words
The composition of claim 1 or claim 2 wherein FK-565 and IL-2 are provided in an injectable formulation said injectable formulation comprising: a biocompatible and FK-565 and IL-2 compatible vehicle; and an immune stimulating amount of FK-565 and/or IL-2 admixed with said vehicle.
Claim 14
Dependent Claim
30 words
The composition of claim 1 or claim 2 adapted for administration to an animal selected from the group consisting of human, bovine, porcine, canine, feline, equine, avian and ovine species.
Claim 15
Dependent Claim
26 words
The composition of claim 12 wherein said animal is selected from the group consisting of livestock and poultry such as cattle, swine, sheep, chickens, and turkeys.
Claim 16
Dependent Claim
21 words
Use of IL-2 for the preparation of a composition for use in synergistically stimulating an animals immune system together with FK-565.
Claim 17
Dependent Claim
21 words
Use of IL-2 for the preparation of a composition for use in synergistically stimulating an animals immune system together with FK-565.
Claim 18
Independent Claim
27 words
A method of enhancing the efficacy of a non-therapeutic vaccine administered to an animal, comprising: administering in conjunction an adjuvant comprising FK-565 and IL-2; and a vaccine.
Claim 19
Independent Claim
27 words
A method of enhancing the efficacy of a non-therapeutic vaccine administered to an animal, comprising: administering in conjunction an adjuvant comprising FK-565 and IL-2; and a vaccine.
Claim 20
Dependent Claim
24 words
The method of claim 15 wherein said adjuvant is administered independently of said vaccine prior to, comtemporaneously with, or subsequent to said vaccine administration.
Claim 21
Dependent Claim
16 words
The method of claim 5 or claim 16 wherein said adjuvant is incorporated in said vaccine.
Claim 22
Dependent Claim
42 words
The method of claim 17 wherein said adjuvant is incorporated in said vaccine in an amount from about 0.001 to about 1000 ug/kg body weight and IL-2 is administered to said animal in an amount from about 10¹ to about 10⁸ units.
Claim 23
Dependent Claim
55 words
An article of manufacture for synergistically stimulating the immune system with FK-565 and IL-2, which comprises: a first container containing an immunostimulating amount of FK-565 in a pharmaceutically acceptable carrier suitable for parenteral or oral administration; and a second container containing an immunostimulating amount of IL-2 in a pharmaceutically acceptable carrier suitable for parenteral administration.
Claim 24
Dependent Claim
55 words
An article of manufacture for synergistically stimulating the immune system with FK-565 and IL-2, which comprises: a first container containing an immunostimulating amount of FK-565 in a pharmaceutically acceptable carrier suitable for parenteral or oral administration; and a second container containing an immunostimulating amount of IL-2 in a pharmaceutically acceptable carrier suitable for parenteral administration.
Claim 25
Dependent Claim
30 words
An article of manufacture for synergistically stimulating the immune system with FK-565 and IL-2, which comprises: a container containing an immunostimulating amount of: IL-2 FK-565, and a pharmaceutically acceptable carrier.
Claim 26
Dependent Claim
30 words
An article of manufacture for synergistically stimulating the immune system with FK-565 and IL-2, which comprises: a container containing an immunostimulating amount of: IL-2 FK-565, and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
No citation records indexed.
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