Patent EP0283959A1 successfully refreshed from Google Patents.
EP0283959A1
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Heterocyclic compounds and their preparation and use
Assignee: Novo Nordisk AS
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Filing: 1988-03-18
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Granted: —
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Expires: 2008-03-18
Abstract
Abstract Heterocyclic dihydroxyquinoxaline compounds having the formula wherein -A-together with the two carbon atoms denoted as 1 and 2 is selected from R 1 , R 2 and R 3 are independently H, halogen, CN, NH,, NO 2 , SO 3 H, SO 2 NH 2 , or CONH 2 The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use. The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters.
Inventors
- 👤 Poul Jacobsen
- 👤 Flemming Elmelund Nielsen
- 👤 Tage Honore
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 08:09
CPC Classifications
C; C07; C07D; C07D241/00; C07D241/36; C07D241/38; C07D241/40; C07D241/44; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
50 words
A heterocyclic compound having the formula I wherein -A-together with the two carbon atoms denoted as 1 and 2 is selected from R I , R 2 and R 3 are independently H, halogen, CN, NH,, NO 2 , SO 3 H, SO 2 NH 2 , or CONH 2
Claim 2
Dependent Claim
50 words
A heterocyclic compound having the formula I wherein -A-together with the two carbon atoms denoted as 1 and 2 is selected from R I , R 2 and R 3 are independently H, halogen, CN, NH,, NO 2 , SO 3 H, SO 2 NH 2 , or CONH 2
Claim 3
Dependent Claim
9 words
A compound according to claim 1 which is 2,3-dihydroxy-6,7-dinitrobenzo(f)quinoxaline
Claim 4
Dependent Claim
9 words
A compound according to claim 1 which is 2,3-dihydroxy-6,10-dinitrobenzo(f)quinoxaline
Claim 5
Dependent Claim
9 words
A compound according to claim 1 which is 6-bromo-2,3-dihydroxy-10-nitrobenzo(f)quinoxaline
Claim 6
Dependent Claim
9 words
A compound according to claim 1 which is 2,3-dihydroxy-6-nitropyrido(2,3-f)quinoxaline
Claim 7
Dependent Claim
26 words
A pharmaceutical composition comprising as active component a heterocyclic compound according to claim 1 or a phar maceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
23 words
A pharmaceutical composition according to claim 6 in the form of an oral dosage unit containing about 10-200 mg of the active compound.
Claim 9
Dependent Claim
41 words
A method of treating an indication related to hyperactivity of the excitatory neurotransmitters, in a subject in need thereof, which comprises the step of administering to the said subject a neurologically-effective, glutamate antagonistic, amount of a heterocyclic compound of Claim 1.
Claim 10
Dependent Claim
273 words
A method of preparing an assymmetrically substituted heterocyclic compound according to claim 1, which comprises a) reacting a compound having the formula II wherein -A-, 1 and 2 have the meanings defined above, with oxalate or a reactive derivative thereof to form a compound of formula I, or b) refluxing a compound having the formula III wherein -A-, 1 and 2 have the meanings defined above and R 4 is lower alkyl in a mineral acid, to form a compound of formula I, or c) nitrating a compound having the formula IV wherein -A-together with the two carbon atoms denoted as 1 and 2 is selected from wherein at least one of R 1 , R 2 and R 3 is hydrogen and the other are as defined above, to form a compound of formula I, or d) reducing a compound having the formula V wherein -A-together with the two carbon atoms denoted as 1 and 2 is selected from wherein at least one of R 1 , R 2 and R 3 is nitro and the other are as defined above, to form a compound of formula I, wherein at least one of R 1 , R 2 and R 3 is amino, or e) reacting a compound having the formula VI wherein -A-together with the carbon atoms denoted as 1 and 2 is selected from wherein at least one of R 1 , R 2 and R 3 is and the other are as defined above, with potassium tetracyanonickelate to form a compound of formula I, wherein at least one of R 1 , R 2 and R 3 is CN.
References Cited (Backward Citations)
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