Patent EP0271332A2 successfully refreshed from Google Patents.
EP0271332A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Topical drug release system
Assignee: Beecham Group PLC
•
Filing: 1987-12-09
•
Granted: —
•
Expires: 2007-12-09
Abstract
Abstract A topical composition containing a dissolved drug or the like (e.g. hydrocortisone acetate) preferably in saturated solution, and a solubiliser (e.g. propylene glycol), and preferably water and an antinucleant, is applied to a water-wetted area of the body, such as the hair or scalp, such that, on mixing with the body water, the resultant drug concentration exceeds the saturated drug solubility in the initially formed resultant mixture, thus giving a supersaturated drug composition.
Inventors
- 👤 Adrian Francis Davis
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 13:24
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/08; A61K31/00; A61K31/56; A61K31/57; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K8/00; A61K8/18; A61K8/30; A61K8/63; A61K9/0012; A61K9/0014; A61Q; A61Q11/00; A61Q5/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
74 words
A method for forming a supersaturated drug composition in situ for topical treatment of a human or animal body, which comprises applying a composition containing the dissolved drug (as herein defined) to a water-wetted area of the body, the composition comprising a solubiliser and sufficient dissolved drug such that, on mixing with the water on the body, the resultant drug concentration is greater than the saturated drug solubility in the initially formed resultant mixture.
Claim 2
Independent Claim
74 words
A method for forming a supersaturated drug composition in situ for topical treatment of a human or animal body, which comprises applying a composition containing the dissolved drug (as herein defined) to a water-wetted area of the body, the composition comprising a solubiliser and sufficient dissolved drug such that, on mixing with the water on the body, the resultant drug concentration is greater than the saturated drug solubility in the initially formed resultant mixture.
Claim 3
Dependent Claim
85 words
A drug composition suitable for forming a supersaturated composition in situ when applied to a water-wetted area of a human or animal body, comprising a drug (as herein defined) dissolved in a carrier system which contains from 0.01 to 1.0% by weight of an antinucleating agent, based on the total weight of the composition, the carrier system comprising from 0 to 50% by weight of water and from 50 to 100% by weight of a solubiliser, based on the total weight of the carrier system.
Claim 4
Dependent Claim
85 words
A drug composition suitable for forming a supersaturated composition in situ when applied to a water-wetted area of a human or animal body, comprising a drug (as herein defined) dissolved in a carrier system which contains from 0.01 to 1.0% by weight of an antinucleating agent, based on the total weight of the composition, the carrier system comprising from 0 to 50% by weight of water and from 50 to 100% by weight of a solubiliser, based on the total weight of the carrier system.
Claim 5
Dependent Claim
22 words
A composition as claimed in claim 2, wherein the carrier system contains from 0.1 to 0.5% by weight of the antinucleating agent.
Claim 6
Dependent Claim
22 words
A composition as claimed in claim 2 or claim 3, wherein the antinucleating agent is selected from hydroxyalkylcelluloses, polyvinylpyrrolidone, and polyacrylic acid.
Claim 7
Dependent Claim
39 words
A composition as claimed in any one of the claims 2 to 4, wherein the solubiliser is selected from propylene glycol, 1,3-propylene diol, polyethylene glycol, ethanol, propanol, glycerine, dimethyl sulphoxide, dimethyl acetamide, dimethyl formamide, hexylene glycol, and propylene carbonate.
Claim 8
Dependent Claim
20 words
A composition as claimed in any one of claims 2 to 5, wherein the drug is saturated in the composition.
Claim 9
Dependent Claim
20 words
A composition as claimed in any one of claims 2 to 6, which additionally comprises a thickening or gelling agent.
Claim 10
Dependent Claim
21 words
A method as claimed in claim 1, wherein the composition is as claimed in any one of claims 2 to 7.
Claim 11
Dependent Claim
22 words
A method as claimed in claim 1 or claim 8, wherein the waterwetted area of the body is the hair or scalp.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.