Quinoline dioic acids and amides

Claim 1

A compound of the formula: wherein: R 1 is H, halogen, C 1 -C 8 alkyl, C 2 -Ca alkenyl, C 2 -C 8 alkynyl, -CF 3 , -OR 2 , -SR 2 , -S(O)R 2 , -S(O) 2 R 2 , -NR 2 R 2 , -CHO, -COOR 2 , -(C=O)R2, -C(OH)R2R 2 , -CN, -N0 2 , substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, or substituted or unsubstituted phenethyl; R 2 is H, C 1 -Ca alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, -CF 3 , substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, or substituted or unsubstituted phenethyl; R 3 is H, halogen, -N0 2 , -CN, -OR 2 , -SR 2 , NR 2 R 2 , or C 1 -C 8 alkyl; CR 2 R 3 may be the radical of a naturally occurring amino acid; R 4 is H, halogen, -N0 2 , -CN, -OR 2 , -SR 2 , NR 2 R 2 , C 1 -C 8 alkyl, or -(C=O)R 2 ; R5 is R 6 is H or C 1 -C 4 alkyl; R 7 is A) a monocyclic or bicyclic heterocyclic radical containing from 3 to 12 nuclear carbon atoms and 1 or 2 nuclear heteroatoms selected from N, S or 0 and with each ring in the heterocyclic radical being formed of 5 or 6 atoms, or B) the radical W-R 8; R 8 contains up to 21 carbon atoms and is (1) a hydrocarbon radical or (2) an acyl radical of an organic acyclic or monocyclic carboxylic acid containing not more than 1 heteroatom in the ring; R 9 is-OR 10 , -SR 10 , or NR 10 R 10 ; R 10 is H, Ci-C 6 alkyl, -(C=O)R 11 , unsubstituted phenyl, unsubstituted benzyl, or two R 10 groups joined to the same N may form a ring of 5 or 6 members containing up to two heteratoms chosen from O,S or N; R 11 is H, c 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, -CF 3 , or unsubstituted phenyl, benzyl, or phenethyl; R 12 is R 2 or halogen; m and m'are independently 0-8; n and n' are independently 0 or 1; p and p' are independently 0-8; m+n+p is 1-10; m'+n'+p' is 0-10; s is 0-3; Q 1 and Q 2 are independently -COOR 2 , tetrazole, -COOR 5 , -CONHS(O) 2 R 11 , -CN, -CONR 10 R 10 , -CHO, -CH 2 0H, -COCH 2 0H, -NHS(O) 2 R 11 ; or if Q 1 or Q 2 is COOH and R 3 is -OH, -SH, or -NHR 2 then Q 1 or Q 2 and R 3 and the carbons through which they are attached may form a heterocyclic ring with loss of water; W is O, S, or NH; X 1 is 0, S, -S(O)-, -S(O) 2 -, -NR 2 , or -CR 2 R 2 -; X 2 is CR 2 R 2 , O, S, S(O), or S(O)2; Y is -CR 2 =CR 2 -, -C=C-, -CR 2 R 2 -X 1 -, -X 1 -CR 2 R 2 -, -CR 2 R 2 -X 1 -CR 2 R 2 -, C=O, O, S, or - NR 2 ; Z 1 and Z 2 are independently -CONR 2- ; and the pharmaceutically acceptable salts thereof.