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EP0267015B1 Expired / Lapsed EP ⏱️ 0.0 years remaining

Stabilized compositions containing epidermal growth factor

Assignee: Ethicon Inc
•
Filing: 1987-11-04
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Granted: 1992-09-02
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Expires: 2007-11-04
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Abstract

No abstract record available.

Inventors

  • 👤 Amy L. Finkenaur

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-26 22:59
CPC Classifications
A; A23; A23C; A23C9/00; A23C9/20; A23C9/206; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1808; A61K47/00; A61K47/30; A61K47/36; A61K47/38; A61K9/00; A61K9/0012; A61K9/0014; A61K9/0048; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L17/00; A61L17/005; A61P; A61P17/00; A61P17/02; A61P27/00; A61P27/02; A61P5/00; A61P5/06; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/80; A61L2300/802

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 61 words
An aqueous medicinal composition containing a growth factor selected from epidermal growth factor, transforming growth factor-alpha, transforming growth factor-beta, basic fibroblast growth factor, acidic fibroblast growth factor, angiogenin, nerve growth factor, insulin-like growth factor, platelet derived growth factor or a mixture thereof and an amount of a water-soluble cellulose polymer sufficient to stabilise said growth factor against loss of biological activity.
Claim 2
Dependent Claim 13 words
The composition of claim 1, wherein the growth factor is epidermal growth factor.
Claim 3
Dependent Claim 15 words
The composition of claim 2, wherein the epidermal growth factor is human epidermal growth factor.
Claim 4
Dependent Claim 26 words
The composition of any one of claims 1 to 3, wherein the cellulose derivative is hydroxypropyl cellulose, methylcellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose or a mixture thereof.
Claim 5
Independent Claim 76 words
A method for stabilising an aqueous medicinal composition containing a growth factor selected from epidermal growth factor, transforming growth factor-alpha, transforming growth factor-beta, basic fibroblast growth factor, acidic fibroblast growth factor, angiogenin, nerve growth factor, insulin-like growth factor, platelet derived growth factor or a mixture thereof, which method comprises incorporating in said composition an amount of a water-soluble cellulose polymer sufficient to stabilise said growth factor against loss of biological activity in the presence of water.
Claim 6
Dependent Claim 17 words
A pharmaceutically compatible cream or gel comprising the composition of any one of claims 1 to 4.
Claim 7
Dependent Claim 21 words
A suture or an absorbent gauze dressing coated or soaked with the composition of any one of claims 1 to 4.
Claim 8
Dependent Claim 37 words
The composition of any one of claims 1 to 4, the cream or gel of claim 6, or the suture or gauze dressing of claim 7 for use in increasing the rate of healing of a wound.
Claim 9
Dependent Claim 16 words
A mother's breast milk substitute comprising the composition of any one of claims 1 to 4.
Claim 10
Dependent Claim 29 words
A mother's breast milk substitute according to claim 9 comprising recombinant human EGF and a nutritional amount of protein capable of providing the amino acids essential for human nutrition.

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