Patent EP0259013A1 successfully refreshed from Google Patents.
EP0259013A1
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EP
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Portable controlled release osmotic infusion device
Assignee: Flora Inc
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Filing: 1987-08-04
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Granted: —
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Expires: 2007-08-04
Abstract
Abstract A portable controlled release osmotic infusion device, which can be activated on demand by the user, comprises a rigid housing (6) containing: (a). a fluid-imbibing assembly, comprising a solvent-containing chamber (7) and a solute-containing chamber (8); the two chambers (7, 8) separated by a rigid semipermeable membrane (12) covered by a thin taut foil seal (5), (b). a drug-containing chamber (10) separated from the fluid-imbibing assembly by a leakproof impermeable elastic diaphragm (9), which expands into the drug-containing chamber (10) in use and drives the drug through a dispensing orifice (1) at a steady rate, and (c). an activating device (4) which ruptures the foil seal (5) described in (a) above and initiates the osmotic action of the device. The osmotic device is filled with drug in solution or suspended form during manufacture and can be stored without deterioration of the contents for prolonged periods of time.
Inventors
- 👤 Richard W. Baker
- 👤 Paul Shrock
- 👤 Verne Helm
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 22:06
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/145; A61M2005/14513; A61M5/14244; A61M5/14248
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
124 words
A portable controlled release osmotic infusion device which can be filled with drug and osmotic fluid, stored for prolonged periods without deterioration and activated on demand by the user, said device comprising: (a) a housing; (b) a fluid-imbibing assembly, comprising a solvent-containing chamber and a solute-containing chamber; the two chambers separated by a rigid semipermeable membrane protected from the solvent during storage by a seal; (c) a drug-containing chamber separated from the fluid-imbibing assembly by a leakproof impermeable elastic diaphragm, which expands into the drug-containing chamber in use and drives the drug through a dispensing orifice at a steady rate, and (d) an activating mechanism which breaks the seal between the semipermeable membrane and the solvent and initiates the pumping action of the device.
Claim 2
Dependent Claim
124 words
A portable controlled release osmotic infusion device which can be filled with drug and osmotic fluid, stored for prolonged periods without deterioration and activated on demand by the user, said device comprising: (a) a housing; (b) a fluid-imbibing assembly, comprising a solvent-containing chamber and a solute-containing chamber; the two chambers separated by a rigid semipermeable membrane protected from the solvent during storage by a seal; (c) a drug-containing chamber separated from the fluid-imbibing assembly by a leakproof impermeable elastic diaphragm, which expands into the drug-containing chamber in use and drives the drug through a dispensing orifice at a steady rate, and (d) an activating mechanism which breaks the seal between the semipermeable membrane and the solvent and initiates the pumping action of the device.
Claim 3
Independent Claim
29 words
A device as claimed in claim I, wherein the seal protecting the semipermeable membrane is metal foil and the activating mechanism is a puncture device that pierces said seal.
Claim 4
Independent Claim
24 words
A device as claimed in claim I, wherein the seal protecting the semipermeable membrane is metal foil and the activating mechanism rips said seal.
Claim 5
Independent Claim
29 words
A device as claimed in Claim I, wherein the seal protecting the semipermeable membrane is a septum and the activating mechanism is a hollow needle that pierces said septum.
Claim 6
Independent Claim
24 words
A device as claimed in Claim I, wherein the seal protecting the semipermeable membrane contains a valve and the activating mechanism opens the valve.
Claim 7
Dependent Claim
21 words
A device as claimed in Claim 1, wherein the elastic diaphragm is a rubber covered by a layer of metal fail.
Claim 8
Independent Claim
19 words
A device as claimed in Claim l, wherein the elastic diaphragm is coated with a vacuum deposited metal film.
Claim 9
Independent Claim
21 words
A device as claimed in any one of the preceding claims, wherein the drug is an antidote to a toxic agent.
Claim 10
Independent Claim
30 words
A device as claimed in any one of the preceding claims, wherein the drug is in the form of a lyophilized solid during storage, and is reconstituted prior to activation.
Claim 11
Independent Claim
17 words
A device as claimed in any one of the preceding claims, wherein the drug is a polypeptide.
Claim 12
Dependent Claim
41 words
II. A device as claimed in any one of the preceding claims, further comprising: (a) A second drug-containing chamber, separate from, but connection to, the first drug-containing chamber; and (b) a means for reducing the volume of said second drug-containing chamber.
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