Patent EP0257915A1 successfully refreshed from Google Patents.
EP0257915A1
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Pharmaceutical formulations comprising microcapsules
Assignee: Innovata Biomed Ltd
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Filing: 1987-08-11
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Granted: —
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Expires: 2007-08-11
Abstract
Abstract Pharmaceutical formulations comprise: (i) microcapsules which consist essentially of a biocompatible polymeric wall material encapsulating a drug, and (ii) a lipid-soluble surfactant which is mixed with the microcapsules or is incorporated within or coats the wall material of the microcapsules. Such formulations may be presented as an aerosol or dry powder for inhalation. Microcapsules with surfactant incorporated in the wall material may be suspended in a pharmaceutically acceptable water-immiscible oil and the resulting suspension emulsified in an aqueous medium to obtain a formulation for oral administration.
Inventors
- 👤 Robert Nichol Boyes
- 👤 Thomas Robert Tice
- 👤 Richard Mac Gilley
- 👤 Kenneth Lawrence Pledger
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 13:00
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/0087; A61K9/0095; A61K9/0012; A61K9/007; A61K9/0073; A61K9/008; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K9/1623; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/10; A61K9/107; A61K9/113
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
41 words
A pharmaceutical formulation comprising: (i) microcapsules which consist essentially of a biocompatible polymeric wall material encapsulating a drug, and (ii) a lipid-soluble surfactant which is mixed with the microcapsules or is incorporated within or coats the wall material of the microcapsules.
Claim 2
Dependent Claim
41 words
A pharmaceutical formulation comprising: (i) microcapsules which consist essentially of a biocompatible polymeric wall material encapsulating a drug, and (ii) a lipid-soluble surfactant which is mixed with the microcapsules or is incorporated within or coats the wall material of the microcapsules.
Claim 3
Dependent Claim
15 words
A formulation according to claim 1, wherein the surfactant is a sorbitan fatty acid ester.
Claim 4
Dependent Claim
12 words
A formulation according to claim 2, wherein the surfactant is sorbitan trioleate.
Claim 5
Dependent Claim
12 words
A formulation according to claim 1, wherein the wall material is biodegradable.
Claim 6
Dependent Claim
16 words
A formulation according to claim 4, which is in the form of an aerosol for inhalation.
Claim 7
Dependent Claim
22 words
A formulation according to claim 5, wherein the concentration of surfactant in the aerosol cannister is from 0.01 to 1% by weight.
Claim 8
Dependent Claim
35 words
A formulation according to claim 4, which is in the form of a dry powder for inhalation and wherein from 1 to 10% by weight of surfactant is incorporated in the walls of the microcapsules.
Claim 9
Dependent Claim
43 words
A formulation according to claim 1, which is in the form of a composition suitable for oral administration wherein the microcapsules, which are coated with surfactant, are suspended in a pharmaceutically acceptable water-immiscible oil which is in turn emulsified in an aqueous medium.
Claim 10
Dependent Claim
45 words
A formulation according to claim 1, wherein the drug is an antibiotic, cardiovascular drug, a drug for a cough or cold preparation, a peptide drug, any other naturally occurring agent or a derivative thereof, an anti-viral agent, an anti-convulsant or chemotherapeutic agents for cancer treatment.
Claim 11
Dependent Claim
25 words
A formulation according to claim 1, wherein the drug is a bronchodilating agent or other anti-asthma drugs such as cortico steroids, disodium chromoglycate and antihistamines.
Claim 12
Dependent Claim
28 words
A formulation according to claim 10, wherein the bronchodilating agent is a beta-adrenergic agonist, a xanthine, an anti-cholinergic agent, a calcium antagonist or a leukotriene or derivative thereof.
Claim 13
Dependent Claim
13 words
A formulation according to claim 11, wherein the drug is salbutamol or terbutaline.
Claim 14
Dependent Claim
23 words
A process for the preparation of a pharmaceutical formulation as defined in claim 1, which process comprises mixing the microcapsules with the surfactant.
Claim 15
Dependent Claim
35 words
A process for the preparation of a pharmaceutical formulation as defined in claim 1, which process comprises exposing the microcapsules encapsulating drug to surfactant so that the surfactant coats the wall material of the microcapsules.
Claim 16
Dependent Claim
32 words
A process according to claim 14, further comprising suspending the microcapsules which have been exposed to surfactant in a pharmaceutically acceptable water-immiscible oil and emulsifying the resulting suspension in an aqueous medium.
Claim 17
Dependent Claim
53 words
A process for the preparation of a pharmaceutical formulation as defined in claim 1, in which the surfactant is incorporated in the wall material of the microcapsules, which process comprises dissolving the polymeric material for the walls in a solvent, dispersing surfactant and drug in the polymer solution and evaporating off the solvent.
References Cited (Backward Citations)
EP0038979A1
Cited
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