Patent EP0249949A2 successfully refreshed from Google Patents.
EP0249949A2
Expired / Lapsed
EP
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Sustained release pharmaceutical preparations
Assignee: Warner Lambert Co LLC
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Filing: 1987-06-16
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Granted: —
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Expires: 2007-06-16
Abstract
Abstract Sustained release solid dosage forms--i.e., tablets pellets, granules, and powders--can be made using a combination of polymeric and ionic particulate materials to modify release profiles, permeability and processability.
Inventors
- 👤 Issac Ghebre Sellassie
- 👤 Russell Nesbitt, Jr.
- 👤 Uma Iyer
- 👤 Mahdi B. Fawzi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-04 09:25
CPC Classifications
A; A61; A61K; A61K47/00; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/585; A61K9/14; A61K9/141; A61K9/143; C; C30; C30B; C30B33/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
82 words
A process for treating a biologically active substance which comprises the steps of: a) contacting at least one active substance with at least one ionically neutral polymer or at least one ionic particulate material; b) producing a composite of neutral polymeric binder, particulate material and active substance in which ion pairs bond the active substance to the particulate material and the core is coated with a neutral coating of polymer to form a membrane; and c) recovering the product of step (2).
Claim 2
Dependent Claim
82 words
A process for treating a biologically active substance which comprises the steps of: a) contacting at least one active substance with at least one ionically neutral polymer or at least one ionic particulate material; b) producing a composite of neutral polymeric binder, particulate material and active substance in which ion pairs bond the active substance to the particulate material and the core is coated with a neutral coating of polymer to form a membrane; and c) recovering the product of step (2).
Claim 3
Dependent Claim
19 words
The process of claim 1 wherein the particulate material is of acidic or basic character prior to step (a).
Claim 4
Dependent Claim
30 words
The process of claim 2 wherein the particulate material is selected from the group consisting of: kaolin, non-kaolin clay, ion exchange resins having acidic or basic character and mixtures thereof.
Claim 5
Dependent Claim
11 words
The process of claim 1 wherein the particulate material is kaolin.
Claim 6
Dependent Claim
23 words
The process of Claim 1 wherein the neutral polymeric binder is selected from the group consisting of cellulosic ethers, acrylics, and polyvinyl esters.
Claim 7
Dependent Claim
27 words
The process of claim 4 wherein the neutral polymer is a water insoluble aqueous polymer selected from the group consisting of acrylic resins, cellulosics, and polyvinyl esters.
Claim 8
Dependent Claim
29 words
The process of claim 6 wherein the polymer is supplied as an aqueous dispersion containing a copolymer derived from monomers selected from acrylic esters, methacrylic esters, and mixtures thereof.
Claim 9
Dependent Claim
18 words
The process of claim 1 wherein the particulate material is an ion-exchange resin having acidic or basic character.
Claim 10
Dependent Claim
32 words
The process of claim 8 wherein the ion exchange resin contains at least one ionic group selected from the group consisting of sulfonates, carboxylates, quaternary ammonium groups, amine groups, and mixtures thereof.
Claim 11
Dependent Claim
13 words
The process of claim 9 wherein the ion exchange resin is strongly acidic.
Claim 12
Dependent Claim
12 words
A product manufactured according to any one of Claims 1 to 10.
References Cited (Backward Citations)
No citation records indexed.
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