Patent EP0249248A2 successfully refreshed from Google Patents.
EP0249248A2
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Purine derivatives
Assignee: Warner Lambert Co LLC
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Filing: 1984-10-26
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Granted: —
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Expires: 2004-10-26
Abstract
Abstract Novel purine derivatives of formula <CHEM> as agents for treating autoimmune diseases are described. Also disclosed are processes for their production and pharmaceutical compositions comprising the compounds.
Inventors
- 👤 Jagadish C. Sircar
- 👤 Charles F. Schwender
- 👤 Mark J. Suto
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 12:52
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/26; C07C; C07C43/00; C07C43/02; C07C43/03; C07C43/14; C07C43/17; C07C43/174; C07C43/1745; C07C43/178; C07C43/1782; C07C43/1785; C07C43/1788; C07C43/20; C07C43/225; C07C43/23
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
168 words
A compound having the following general formula: or a tautomeric isomer thereof, or a pharmaceutically acceptable acid or salt base thereof, wherein: R₁ is -OH or -SH; R₂ is a hydrogen atom or -NHR in which R is hydrogen or -COR₆; R₆ is a C 1-4 alkyl radical, an aryl radical or an aralkyl radical; X is an oxygen or sulphur atom; and R₇ is a C 1-8 alkyl radical, a cycloalkyl radical of from five to seven ring members, a clycloalklalkyl radical, an aryl radical or an aralkyl radical; the term "aryl" relates to aromatic rings which are unsubstituted or substituted by halo, alkyl of from 1 to 4 carbon atoms or alkoxy of from 1 to 4 carbon atoms; the term "aralkyl" relates to an aromatic ring attached to an alkyl group of from 1 to 4 carbon atoms; and the term "cycloalkylalkyl" relates to a cycloalkyl group of from five to seven ring members attached to an alkyl of from 1 to 4 carbon atoms.
Claim 2
Dependent Claim
168 words
A compound having the following general formula: or a tautomeric isomer thereof, or a pharmaceutically acceptable acid or salt base thereof, wherein: R₁ is -OH or -SH; R₂ is a hydrogen atom or -NHR in which R is hydrogen or -COR₆; R₆ is a C 1-4 alkyl radical, an aryl radical or an aralkyl radical; X is an oxygen or sulphur atom; and R₇ is a C 1-8 alkyl radical, a cycloalkyl radical of from five to seven ring members, a clycloalklalkyl radical, an aryl radical or an aralkyl radical; the term "aryl" relates to aromatic rings which are unsubstituted or substituted by halo, alkyl of from 1 to 4 carbon atoms or alkoxy of from 1 to 4 carbon atoms; the term "aralkyl" relates to an aromatic ring attached to an alkyl group of from 1 to 4 carbon atoms; and the term "cycloalkylalkyl" relates to a cycloalkyl group of from five to seven ring members attached to an alkyl of from 1 to 4 carbon atoms.
Claim 3
Dependent Claim
54 words
A compound according to Claim 1, wherein: R₁ is -OH; R₆ is a C 1-4 alkyl radical, a phenyl or a benzyl radical; X is an oxygen atom; and R₇ is a C 1-8 alkyl radical, a cycloalkyl radical of five to seven ring members, a cycloalkylalkyl radical, a phenyl or a benzyl radical.
Claim 4
Dependent Claim
34 words
A compound according to Claim 2, wherein: R₆ is a methyl radical; and R₇ is a C 2-8 alkyl radical, a cyclopentyl, a cyclohexyl, a cyclopentylmethyl, a cyclohexylmethyl, a phenyl or a benzyl radical.
Claim 5
Dependent Claim
16 words
A compound according to Claim 3 , and being 2-amino-9-[[2-(heptyloxy)-1-(hydroxymethyl)ethoxy] methyl]-1,9-dihydro-6 H -purin-6-one; 2-amino-1,9-dihydro-9-[[1-(hydroxymethyl)-2-phenoxyethoxy]methyl]-6 H -purin-6-one.
Claim 6
Dependent Claim
20 words
A pharmaceutical composition comprising a compound according to any preceding claim, in admixture with a pharmaceutically acceptable carrier or diluent.
References Cited (Backward Citations)
No citation records indexed.
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