Patent EP0245073A2 successfully refreshed from Google Patents.
EP0245073A2
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EP
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A complete glucose monitoring system with an implantable, telemetered sensor module
Assignee: University of California Berkeley
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Filing: 1987-05-05
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Granted: —
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Expires: 2007-05-05
Abstract
Abstract An electrochemical system includes a sensor module suitable for implantation in the body to monitor glucose and oxygen levels therein. The module has two oxygen sensors situated in an oxygen-permeable housing, arranged in a tandem relationship, and recessed in the housing, one sensor being unaltered and the other contacting glucose oxidase allowing for differential measurement of oxygen content in bodily fluids or tissues indicative of glucose levels. The module includes a communication capability for transmitting measurement information to an external recording device outside the body.
Inventors
- 👤 David A. Gough
- 👤 Joseph Y. Lucisano
- 👤 Jon C. Armour
- 👤 Brian D. Mckean
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 11:15
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14865; A61B5/0002; A61B5/0031; Y; Y10; Y10S; Y10S128/00; Y10S128/903
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
207 words
An electrochemical system implantable into a body for detecting glucose and oxygen levels in fluids or tissues therein and capable of transmitting information about said glucose and oxygen levels outside said body, comprising: a housing implantable in a body; first and second oxygen sensor means for measuring an oxygen content differential in bodily fluids, said first and second oxygen sensor means disposed in said housing in a tandem relationship, in which said first oxygen sensor means is situated behind said second oxygen sensor means and said first and second oxygen sensor means are recessed in said housing and in fluid communication with fluids or in contact with tissues present in said body, said first oxygen sensor means being unaltered and said second oxygen sensor means containing glucose oxidase for oxidation of glucose; implantable electronic circuit means responsive to said first and second oxygen sensor means for providing a signal indicative of an oxygen content differential in said fluids or tissues; telemetry means for communicating said signal from the interior to the exterior of said body; and an external means outside of said body and responsive to said telemetry means for connecting said oxygen content differential to glucose levels in said fluids or tissues, based upon said signal.
Claim 2
Dependent Claim
207 words
An electrochemical system implantable into a body for detecting glucose and oxygen levels in fluids or tissues therein and capable of transmitting information about said glucose and oxygen levels outside said body, comprising: a housing implantable in a body; first and second oxygen sensor means for measuring an oxygen content differential in bodily fluids, said first and second oxygen sensor means disposed in said housing in a tandem relationship, in which said first oxygen sensor means is situated behind said second oxygen sensor means and said first and second oxygen sensor means are recessed in said housing and in fluid communication with fluids or in contact with tissues present in said body, said first oxygen sensor means being unaltered and said second oxygen sensor means containing glucose oxidase for oxidation of glucose; implantable electronic circuit means responsive to said first and second oxygen sensor means for providing a signal indicative of an oxygen content differential in said fluids or tissues; telemetry means for communicating said signal from the interior to the exterior of said body; and an external means outside of said body and responsive to said telemetry means for connecting said oxygen content differential to glucose levels in said fluids or tissues, based upon said signal.
Claim 3
Dependent Claim
49 words
The electrochemical system of Claim 1 wherein said housing comprises a hollow catheter made of oxygen permeable material drawn from the group consisting of polydimethylsiloxane, polymers of tetrafluoroethylene or its fluoro-chloro analogs alone or as copolymers with ethylene or propylene, polyethylene, polypropylene, cellulose acetate, and other oxygen-abiding polymeric materials.
Claim 4
Dependent Claim
43 words
The electrochemical system of Claim 2 wherein said catheter is a multilumen catheter and said first oxygen sensor means is disposed in a first lumen of said catheter and said second oxygen sensor means is disposed in a second lumen of said catheter.
Claim 5
Dependent Claim
48 words
The electrochemical system of Claim 2 wherein said first oxygen sensor means comprises an electrically insulating support means having a multi-electrode assembly mounted therein in a substantially parallel spaced relationship containing a working electrode, a counter electrode, and reference electrode, said assembly having an active exposed working face.
Claim 6
Dependent Claim
81 words
The electrochemical system of Claim 4 wherein said second oxygen sensor comprises an electrically insulating support means having a three electrode assembly mounted therein in a substantially parallel spaced relationship containing a working electrode, a counter electrode, and reference electrode, said assembly having an active exposed working face; and a hydrophobic membrane about said active exposed working face and in communication with a second membrane, said second membrane containing glucose oxidase therein and being accessible to said bodily fluids or tissues.
Claim 7
Dependent Claim
43 words
The electrochemical system of Claim 5 wherein said second membrane is permeable to glucose and oxygen, and is fabricated from hydrophilic materials drawn from the group consisting of polyacrylamide, cross-linked proteins, polyhydroxy-ethylmethacrylate and its derivatives, and other hydrophilic proteins, polymers and copolymers, thereof.
Claim 8
Dependent Claim
48 words
The electrochemical system of Claim 5 wherein said hydrophobic membrane is permeable to oxygen and relatively impermeable to glucose, and is fabricated from polydimethylsiloxyane, polymers of tetrafluoroethylene, or its fluoro chloro analogs or as copolymers with ethylene or propylene, polyethylene, polypropylene, cellulose acetate, and other oxygen-abiding polymeric materials.
Claim 9
Dependent Claim
13 words
The electrochemical system of Claim 1 wherein said housing includes a bilumen catheter.
Claim 10
Dependent Claim
23 words
The electrochemical system of Claim 8 wherein said first and second oxygen sensor means are situated in different lumens of said bilumen catheter.
Claim 11
Dependent Claim
53 words
The electrochemical system of Claim 1 wherein said first and second oxygen sensor means produce respective first and second sensor signals, each representative of an oxygen level in said fluids or tissues and said electronic circuit means includes means for intermittently sampling said first and second sensor signals to produce said differential signal.
Claim 12
Dependent Claim
43 words
The electrochemical system of Claim 10 wherein said telemetry means includes a voltage-controlled oscillator having a frequency of oscillation determined by a sensor signal and a transmitter which modulates a transmitter carrier in response to the frequency of oscillation of said voltage-controlled oscillator.
Claim 13
Dependent Claim
47 words
The electrochemical system of Claim 11 wherein said external means includes demodulating means for obtaining said first and second sensor signals from said transmitted carrier and programmable processing means for combining said first and second sensor signals according to predetermined calibration characteristics to obtain said glucose levels.
Claim 14
Dependent Claim
120 words
An electrochemical system implantable into a body for detecting glucose and oxygen levels in fluids or tissues therein comprising a housing implantable in a body; first and second oxygen sensor means for measuring an oxygen content differential in bodily fluids, said first and second oxygen sensor means disposed in said housing in a tandem relationship and for implanting in fluid communication with fluids or in contact with tissues present in a body, said first oxygen sensor means being unaltered and said second oxygen sensor means containing glucose oxidase for oxidation of glucose; and means for communicating from the interior to the exterior of a body for communicating a signal indicative of an oxygen content differential in said fluids or tissues.
Claim 15
Dependent Claim
120 words
An electrochemical system implantable into a body for detecting glucose and oxygen levels in fluids or tissues therein comprising a housing implantable in a body; first and second oxygen sensor means for measuring an oxygen content differential in bodily fluids, said first and second oxygen sensor means disposed in said housing in a tandem relationship and for implanting in fluid communication with fluids or in contact with tissues present in a body, said first oxygen sensor means being unaltered and said second oxygen sensor means containing glucose oxidase for oxidation of glucose; and means for communicating from the interior to the exterior of a body for communicating a signal indicative of an oxygen content differential in said fluids or tissues.
References Cited (Backward Citations)
No citation records indexed.
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