Antihypercholesterolemic compounds

Claim 1

' A compound represented by the following general structural formulae (I) or (II): wherein: n is 0 to 5; R 1 is C 1-3 alkyl; R 2 is hydrogen or C 1-3 alkyl; R 3 and R 4 independently are hydrogen, C 1-3 alkyl, C 3-7 cycloalkyl, phenyl or substituted phenyl in which the substituents are X and Y and when n is 2 to 5, each of the R 3 s and R 4 s are independently hydrogen, C 1-3 alkyl, C 3-7 cycloalkyl or only one of the R 3 s and R 4 s are phenyl or substituted phenyl; R 5 is hydrogen or hydroxy; R 6 is selected from the group consisting of a) in which R 15 is hydrogen or C 1-3 alkyl, b) in which R 16 and R 17 independently are hydrogen or C 1-3 alkyl or R 16 and R 17 together with the nitrogen atom to which they are attached form a heterocycle selected from piperidinyl, morpholinyl, pyrrolidinyl, piperazinyl or thiomorpholinyl, and c) which q is 0 to 2 and R 18 is hydrogen, C 1-5 alkyl, phenyl, and substituted phenyl wherein the substitutents are X and Y; A is or R 7 in which R is hydrogen or hydroxy; B is - HR 8 in which R 8 is hydrogen or hydroxy; and a, b, c and d represent single bonds, one of a, b, c, or d represents a double bond, or both a and c or both b and d represent double bonds provided that when a is a double bond, A is or CH= and when d is a double bond B is =C H ; and X and Y independently are hydrogen, halogen, trifluoromethyl, C 1-3 alkyl, nitro, cyano or a group selected from: a) R 9 O(CH 2 ) m in which m is 0 to 3 and R is hydrogen, C 1-3 alkyl or hydroxy-C 1-3 alkyl; b) in which R 10 is hydrogen, C 1-3 alkyl, hydroxy-C2-3 alkyl, phenyl, naphthyl, amino-C 1-3 alkyl, C 1-3 alkylamino-C 1-3 alkyl, di(C 1-3 alkyl)amino-C 1-3 alkyl, hydroxy-C2-3 alkylamino-C 1-3 alkyl or di(hydroxy-C 2-3 alkyl)amino-C 1-3 alkyl; c) in which R 11 is hydrogen, C 1-3 alkyl, hydroxy-C 1-3 alkyl, C 1-3 alkoxy-C 1-3 alkyl, phenyl or naphthyl; d) R 12 R 13 N(CH 2 ) m , or in which R 12 and R 13 independently are hydrogen, C 1-3 alkyl, hydrogy-C 2-3 alkyl or together with the nitrogen atom to which they are attached form a heterocycle group selected from piperidinyl, pyrrolidinyl, piperazinyl, morpholinyl or thiomorpholinyl; e) R 14 S(O) p (CH 2 ) m in which p is 0 to 2 and R 14 is hydrogen, C 1-3 alkyl, amino, C l-3 alkylamino or di(C 1-3 alkyl)-amino; Z is hydrogen, C 1-5 alkyl or C 1-5 alkyl sustituted with a member of the group consisting of phenyl, dimethylamino or acetylamino; or a pharmaceutically acceptable salt of a compound of the formula (II) in which Z is hydrogen.