Patent EP0236987A2 successfully refreshed from Google Patents.
EP0236987A2
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Chemically modified protein and production thereof
Assignee: F Hoffmann La Roche AG
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Filing: 1987-03-06
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Granted: —
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Expires: 2007-03-06
Abstract
Abstract The invention provides chemically modified proteins having a group of the formula: wherein R represents a hydrogen atom or a lower alkyl, m represents an optional positive integer and n represents an integer I to 4, the group being bonded to at least one primary amino group of the protein, and a method of producing the same. The chemically modified proteins according to the invention can be produced by reacting a protein with an imidoester of the formula: wherein R, n and m are as defined above, R' represents a group constituting an imidoester with an adjacent imidoyl group. The chemically modified proteins according to the invention are useful as drugs, among others.
Inventors
- 👤 Hayao Ueno
- 👤 Masahiko Fujino
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 13:56
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/54; C07K14/55; C07K1/00; C07K1/107; C07K1/1072; C07K1/1077; C07K14/555; C07K14/56; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
48 words
A chemically modified protein having a group of the formula: wherein R represents a hydrogen atom or a lower alkyl, m represents an optional positive integer and n represents an integer I to 4, the group being bonded to at least one primary amino group of the protein.
Claim 2
Dependent Claim
48 words
A chemically modified protein having a group of the formula: wherein R represents a hydrogen atom or a lower alkyl, m represents an optional positive integer and n represents an integer I to 4, the group being bonded to at least one primary amino group of the protein.
Claim 3
Dependent Claim
19 words
The modified protein according to claim I, wherein R is a lower alkyl having I to 18 carbon atoms.
Claim 4
Dependent Claim
13 words
The modified protein according to claim I, wherein m is 500 or less.
Claim 5
Dependent Claim
23 words
The modified protein according to claim I, wherein the molecular weight of the group of the formula - (1) is 25,000 or less.
Claim 6
Dependent Claim
18 words
The modified protein according to claim I, wherein the protein has molecular weight of from 5,000 to 50,000.
Claim 7
Independent Claim
130 words
A method of producing a chemically modified protein having a group of the formula: wherein R represents a hydrogen atom or a lower alkyl, m represents an optional positive integer and n represents an integer 1 to 4, the group being bonded to at least one primary amino group of the protein, which comprises reacting a protein with an imidoester of the formula: wherein R represents a hydrogen atom or a lower alkyl, R' represents a group constituting an imidoester with an adjacent imidoyl group, m represents an optional positive integer, n represents an integer from I to 4, or with a salt of imidoester of the formula. wherein R, R', m and n have the same meaning as above, x is a positive integer, X is an acid residue.
Claim 8
Independent Claim
130 words
A method of producing a chemically modified protein having a group of the formula: wherein R represents a hydrogen atom or a lower alkyl, m represents an optional positive integer and n represents an integer 1 to 4, the group being bonded to at least one primary amino group of the protein, which comprises reacting a protein with an imidoester of the formula: wherein R represents a hydrogen atom or a lower alkyl, R' represents a group constituting an imidoester with an adjacent imidoyl group, m represents an optional positive integer, n represents an integer from I to 4, or with a salt of imidoester of the formula. wherein R, R', m and n have the same meaning as above, x is a positive integer, X is an acid residue.
Claim 9
Dependent Claim
94 words
A use of a compound expressed by the formula: wherein R represenEs a hydrogen atom or a lower alkyl, R' represents a group constituting an imidoester with an adjacent imidoyl group, m represents an optional positive integer, n represents an integer from I to 4, or the salt thereof, to produce a chemically modified protein having a group of the formula: wherein R, m and n have the same meaning as defined above, the group being bonded to at least one primary amino group of the protein, as a chemically modifying agent for protein.
Claim 10
Dependent Claim
94 words
A use of a compound expressed by the formula: wherein R represenEs a hydrogen atom or a lower alkyl, R' represents a group constituting an imidoester with an adjacent imidoyl group, m represents an optional positive integer, n represents an integer from I to 4, or the salt thereof, to produce a chemically modified protein having a group of the formula: wherein R, m and n have the same meaning as defined above, the group being bonded to at least one primary amino group of the protein, as a chemically modifying agent for protein.
Claim 11
Dependent Claim
25 words
A use of the chemically modifying agent according to claim 7, wherein R' represents a group of -OR" wherein R" represents alkyl, aryl or aralkyl.
Claim 12
Dependent Claim
23 words
A use of the chemically modifying agent according to claim 7, wherein R is a lower alkyl having I to 18 carbon atoms.
Claim 13
Dependent Claim
17 words
A use of the chemically modifying agent according to claim 7, wherein m is 500 or less.
References Cited (Backward Citations)
No citation records indexed.
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