Patent US2542777A successfully refreshed from Google Patents.
Patent EP0235805A2 successfully refreshed from Google Patents.
EP0235805A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Improvements relating to immunosuppression
Assignee: The Royal Free Hospital
•
Filing: 1987-03-04
•
Granted: —
•
Expires: 2007-03-04
Abstract
Abstract A cocktail of anti T-cell monoclonal antibodies of different specificity, of which at least one is of the IgG class, and at least one is of the IgM class, is more effective in immunosuppression of organ transplant recipients than individual monoclonal antibodies.
Inventors
- 👤 George Janossy
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 17:42
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/2803; C07K16/2809; C07K16/2896; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
38 words
A composition comprising a mixture of monoclonal antibodies to T-cell surface antigens, the mixture canprising at least one antibody of the I gG type and at least one antibody of the IgM type, said antibodies differing in specificity.
Claim 2
Dependent Claim
38 words
A composition comprising a mixture of monoclonal antibodies to T-cell surface antigens, the mixture canprising at least one antibody of the I gG type and at least one antibody of the IgM type, said antibodies differing in specificity.
Claim 3
Dependent Claim
18 words
A composition according to Claim 1 in which at least one antibody is of the IgG 2 subclass.
Claim 4
Dependent Claim
13 words
A composition according to Claim 2 in which the IgG antibody is RFT-2.
Claim 5
Dependent Claim
19 words
A composition according to any one of Claims 1 - 3 in which the IgM antibody is T10 B9.
Claim 6
Dependent Claim
26 words
A composition according to any one of the previous claims in which the weight ratio of I gM to IgG antibodies is fran 10:1 to 1:5.
Claim 7
Dependent Claim
29 words
A composition according to Claim 5 in the form of a solution in sterile saline for injection containing fran 2-10 mg/ml IgG antibody and from 4-20 mg/ml IgM antibody.
Claim 8
Dependent Claim
48 words
A composition according to Claim 5 in the form of a solution in sterile saline for infusion containing 0.01 - 0.5 mg/ml of IgG antibody and from 0.02 - 1 mg/ml of IgM antibody, together with 0.5 - 4.5 % wt. human serum albumin or heparinized human blood.
Claim 9
Dependent Claim
45 words
At least one monoclonal antibody against T -cell surface antigens of the IgG type and at least one monoclonal antibody againstT-cell surface antigens of the IgM type in association with each other for use in immunosuppression of the mammalian system, said antibodies differing in specificity.
Claim 10
Dependent Claim
45 words
At least one monoclonal antibody against T -cell surface antigens of the IgG type and at least one monoclonal antibody againstT-cell surface antigens of the IgM type in association with each other for use in immunosuppression of the mammalian system, said antibodies differing in specificity.
Claim 11
Dependent Claim
48 words
A twin-pack containing separate unit dose forms of at least two monoclonal antibodies to T-cell surface antigen, at least one antibody being of the IgG type and at least one antibody of the IgM type said antibodies differing in specificity together with instructions for mixing or concomitant administration.
Claim 12
Dependent Claim
48 words
A twin-pack containing separate unit dose forms of at least two monoclonal antibodies to T-cell surface antigen, at least one antibody being of the IgG type and at least one antibody of the IgM type said antibodies differing in specificity together with instructions for mixing or concomitant administration.
Claim 13
Dependent Claim
44 words
A double-barrelled syringe containing, in one barrel, a solution of a monoclonal antibody of IgG type to a T-cell surface antigen and, in the other barrel, a solution of a monoclonal antibody of IgM type to a T-cell-surface antigen, said antibodies differing in specificity.
Claim 14
Dependent Claim
44 words
A double-barrelled syringe containing, in one barrel, a solution of a monoclonal antibody of IgG type to a T-cell surface antigen and, in the other barrel, a solution of a monoclonal antibody of IgM type to a T-cell-surface antigen, said antibodies differing in specificity.
Claim 15
Dependent Claim
52 words
Claims for Austria, Greece, Spain 1. A method for the production of a synergistic canposition for immunosuppression canprising a mixture of monoclonal antibodies to T-cell surface antigens, comprising mixing together at least one antibody of the IgG type and at least one antibody of the IgM type, said antibodies differing in specificity.
Claim 16
Dependent Claim
18 words
A method according to Claim 1 in which at least one antibody is of the IgG 2 subclass.
Claim 17
Dependent Claim
13 words
A method according to Claim 2 in which the IgG antibody is RFT-2.
Claim 18
Dependent Claim
14 words
A method according to Claim 1 in which the IgM antibody is T10 B9.
Claim 19
Dependent Claim
21 words
A method according to Claim 1 in which the weight ratio of IgM to IgG antibodies is fran 10:1 to 1:5.
Claim 20
Dependent Claim
33 words
A method according to Claim 5 in which the antibodies are dissolved in sterile saline to give a solution for injection containing from 2-10 mg/ml IgG antibody and from 4-20 mg/ml IgM antibody.
Claim 21
Dependent Claim
52 words
A method according to Claim 5 in which the antibodies are dissolved in sterile saline to give a solution for infusion containing 0.01 - 0.5 mg/ml of IgG antibody and from 0.02 - 1 mg/ml of IgM antibody, together with 0.5 - 4.5 % wt. human serum albumin or heparinized human blood.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.