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Patent EP0230647A2 successfully refreshed from Google Patents.
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EP0230647A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Method for producing a sustained release formulation

Assignee: Koken Co Ltd
•
Filing: 1986-12-23
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Granted: —
•
Expires: 2006-12-23
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Abstract

Abstract Described is a method for preparing a sustained release formulation utiliing collagen and/or gelatin as a carrier, which comprises the steps: (i) preparing a uniform and high concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and/or gelatin, and water or an admixture consisting of water and a hydro­philic organic solvent under one of the conditions selected from: (A) the pH of the mixture is kept below 5 and the salt concentration of the mixture is retained below fiber-forming concentration; (B) chemically modified collagen and/or gelatin is employed; and (C) glucose is added to the mixture; (ii) molding the resultant mixture; and (iii) gradually eliminating the solvent from the molded product.

Inventors

  • 👤 Keiji Fujioka
  • 👤 Shigeji Sato
  • 👤 Yoshio Sasaki
  • 👤 Teruo Miyata
  • 👤 Masayasu Furuse
  • 👤 Hiromi Naito

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-24 22:07
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2063; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1658; A61K9/2013; A61K9/2018

Claims Analysis

Total Claims: 7
Claim 1
Independent Claim 116 words
A method for preparing a sustained release formulation utilizing collagen and/or gelatin as a carrier, which comprises the steps: (i) preparing a uniform and high concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and/or gelatin, and water or an admixture consisting of water and a hydro­philic organic solvent under one of the conditions selected from: (A) the pH of the mixture is kept below 5 and the salt concentration of the mixture is retained below fiber-forming concentration; (B) chemically modified collagen and/or gelatin is employed; and (C) glucose is added to the mixture; (ii) molding the resultant mixture; and (iii) gradually eliminating the solvent from the molded product.
Claim 2
Independent Claim 116 words
A method for preparing a sustained release formulation utilizing collagen and/or gelatin as a carrier, which comprises the steps: (i) preparing a uniform and high concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and/or gelatin, and water or an admixture consisting of water and a hydro­philic organic solvent under one of the conditions selected from: (A) the pH of the mixture is kept below 5 and the salt concentration of the mixture is retained below fiber-forming concentration; (B) chemically modified collagen and/or gelatin is employed; and (C) glucose is added to the mixture; (ii) molding the resultant mixture; and (iii) gradually eliminating the solvent from the molded product.
Claim 3
Dependent Claim 24 words
A method of Claim 1 wherein the concentration of the collagen and/or gelatin is adjusted to the range between 10 and 40 w/v %.
Claim 4
Dependent Claim 29 words
A method of Claim 1 wherein the gradual elimination of the solvent consists of air-drying the molded product under atmosphere of the relative humidity of 50 to 80 %.
Claim 5
Dependent Claim 73 words
A method of Claim 1 wherein the gradual elimination of the solvent consists of immersing the molded product repeatedly in a mixture of water and a hydrophilic organic solvent, on condition that a mixture containing an increasing amount of the organic solvent is employed each time, thereby the water contained in the molded product is gradually replaced by the organic solvent, and finally, removing the organic solvent held by the product by air-­drying.
Claim 6
Dependent Claim 37 words
A method of Claim 1 wherein the molding process of step (ii) consists of refrigerating the uniform and high concentrated mixture charged in a template and removing the molded product from the template in the refrigerated state.
Claim 7
Dependent Claim 9 words
Sustained release formulation obtainable in accordance with claim 1.

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