Patent EP0223613A2 successfully refreshed from Google Patents.
EP0223613A2
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Compounds that selectively bind sodium
Assignee: GE Healthcare Ltd
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Filing: 1986-11-20
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Granted: —
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Expires: 2006-11-20
Abstract
Abstract A compound having the property of selectively binding sodium ions in the presence of potassium ions and having the formula: where X is - O - or and where any aromatic ring may be substituted and/or may form part of a fused aromatic ring system. At least one of the aromatic rings may be substituted by a spectroscopic reporter group, a group which permits the compound to enter and remain in a cell and/or an electron donating or withdrawing group. A method of determining cytoplasmic sodium concentration by using this compound as a probe is also described.
Inventors
- 👤 Gerald Arthur Dep. Of Biochemistry Smith
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 14:34
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/02; C07D498/08; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/84
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
46 words
A compound having the property of selectively binding sodium ions in the presence of potassium ions and having the formula 1: where X is - O - or and where any aromatic ring may be substituted and/or may form part of a fused aromatic ring system.
Claim 2
Dependent Claim
46 words
A compound having the property of selectively binding sodium ions in the presence of potassium ions and having the formula 1: where X is - O - or and where any aromatic ring may be substituted and/or may form part of a fused aromatic ring system.
Claim 3
Dependent Claim
20 words
A compound as claimed in claim 1, wherein at least one aromatic ring is substituted by a spectroscopic reporter group.
Claim 4
Dependent Claim
29 words
A compound as claimed in claim 2, wherein at least one aromatic ring is substituted by a group which permits the compound to enter and remain in a cell.
Claim 5
Dependent Claim
18 words
A compound as claimed in claim 3, wherein the group is an acetoxymethyl ester of an anilinodiacetic acid.
Claim 6
Dependent Claim
27 words
A compound as claimed in any one of claims 1 to 4, wherein at least one aromatic ring is substituted by an electron donating or withdrawing group.
Claim 7
Dependent Claim
21 words
A compound as claimed in any one of the preceding claims, wherein X is or and Y is -OEt or -OH
Claim 8
Dependent Claim
35 words
A method which comprises introducing a compound according to claim 3 or claim 4 into the cytoplasm of intact cells, and using a signal generated by the spectroscopic reporter group to determine cytoplasmic sodium concentration.
References Cited (Backward Citations)
No citation records indexed.
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