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EP0219979A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Treating animals using IL-2, formulations therefor and their preparation

Assignee: Cetus Oncology Corp Te Emeryville Californ
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Filing: 1986-09-19
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Granted: —
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Expires: 2006-09-19
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Abstract

Abstract Methods and compositions (and their preparation) for protecting an animal against stress-induced syndrome, or for enhancing the immune response of an animal to a vaccine, or enhancing weight gain in an animal, which employ Il-2 as an active ingredient are described.

Inventors

  • 👤 Jack Henry Nunberg
  • 👤 Arthur Debney Newell
  • 👤 Michael Varian Doyle
  • 👤 Thomas James White

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-11-07 02:25
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/20; A61K38/2013; A61K38/22; A61K38/27; A61K39/00; A61K39/39; A61K2039/555; A61K2039/55511; A61K2039/55522; A61K2039/55527; A61K2039/55533

Claims Analysis

Total Claims: 21
Claim 1
Independent Claim 34 words
A formulation for protecting an animal against a stress-induced syndrome, or for enhancing the immune response of an animal to a vaccine, or enhancing weight gain in an animal, which formulation comprises an IL-2.
Claim 2
Dependent Claim 34 words
A formulation for protecting an animal against a stress-induced syndrome, or for enhancing the immune response of an animal to a vaccine, or enhancing weight gain in an animal, which formulation comprises an IL-2.
Claim 3
Dependent Claim 12 words
A formulation as claimed in claim 1 wherein the IL-2 is hIL-2.
Claim 4
Dependent Claim 16 words
A formulation as claimed in claim 2 wherein the hIL-2 is a water-soluble form of hIL-2.
Claim 5
Dependent Claim 13 words
A formulation as claimed in claim 3 wherein the hIL-2 is PEGylated hIL-2.
Claim 6
Dependent Claim 19 words
A formulation as claimed in anyone of claims 2, 3, or 4 wherein the hIL-2 is des-alanyl-rIL-2 ser 125
Claim 7
Dependent Claim 35 words
A formulation as claimed in any one of claims 1 to 5 wherein the IL-2 is in the form of a continuous release formulation or is in the form of a single sustained action formulation.
Claim 8
Dependent Claim 47 words
An IL-2 for use in a method for protecting an animal against a stress-induced syndrome, or for enhancing the immune response of an animal to a vaccine, or enhancing weight gain in an animal, which method comprises administering an effective amount of the IL-2 to the animal.
Claim 9
Dependent Claim 47 words
An IL-2 for use in a method for protecting an animal against a stress-induced syndrome, or for enhancing the immune response of an animal to a vaccine, or enhancing weight gain in an animal, which method comprises administering an effective amount of the IL-2 to the animal.
Claim 10
Dependent Claim 17 words
A formulation for enhancing the immune response of a human to a vaccine which composition comprises hIL-2.
Claim 11
Dependent Claim 17 words
A formulation for enhancing the immune response of a human to a vaccine which composition comprises hIL-2.
Claim 12
Dependent Claim 32 words
An hIL-2 for use in a method for enhancing the immune response of a human to a vaccine which method comprises administering hIL-2 to the human as part of the vaccination regime.
Claim 13
Dependent Claim 32 words
An hIL-2 for use in a method for enhancing the immune response of a human to a vaccine which method comprises administering hIL-2 to the human as part of the vaccination regime.
Claim 14
Dependent Claim 36 words
The use of an IL-2 in preparing a medicament for protecting an animal against a stress-induced syndrome, or for enhancing the immune response of an animal to a vaccine, or enhancing weight gain in an animal.
Claim 15
Dependent Claim 36 words
The use of an IL-2 in preparing a medicament for protecting an animal against a stress-induced syndrome, or for enhancing the immune response of an animal to a vaccine, or enhancing weight gain in an animal.
Claim 16
Dependent Claim 42 words
A process for preparing a formulation for protecting an animal against a stress-induced syndrome, or for enhancing the immune response of an animal to a vaccine, or enhancing weight gain in an animal, which process comprises formulating an IL-2 for such use.
Claim 17
Dependent Claim 42 words
A process for preparing a formulation for protecting an animal against a stress-induced syndrome, or for enhancing the immune response of an animal to a vaccine, or enhancing weight gain in an animal, which process comprises formulating an IL-2 for such use.
Claim 18
Independent Claim 20 words
A method for enhancing weight gain in an animal comprising administering an effective amount of an IL-2 to the animal.
Claim 19
Independent Claim 20 words
A method for enhancing weight gain in an animal comprising administering an effective amount of an IL-2 to the animal.
Claim 20
Dependent Claim 57 words
An IL-2 for use as claimed in claim 7 or claim 9, a formulation as claimed in claim 8, the use claimed in claim 10, a process as claimed in claim 11, or a method as claimed in claim 12, in each case further defined by the specific feature of any one of claims 2 to 6.
Claim 21
Dependent Claim 45 words
A method as claimed in claim 7 or the use claimed in claim 10 wherein the IL-2 is to be in the form of a continuous release formulation and the IL-2 is to be administered continuously at a rate above 10³ and below 10⁶ units/kg/day.

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