Patent EP0214803A2 successfully refreshed from Google Patents.
EP0214803A2
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Blood fractionation system, apparatus and pathway and method of processing blood
Assignee: Fisons Ltd
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Filing: 1986-08-26
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Granted: —
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Expires: 2006-08-26
Abstract
Abstract There is described a blood fractionation system, apparatus and method of processing blood. There is also described a blood fractionation pathway (1 - 15) for use with a centrifugal blood fractionation apparatus (16 - 31) and preferably including a substantially toroidal separation chamber (1).
Inventors
- 👤 Kenneth Frederick Burrett
- 👤 James Oscar Molloy
- 👤 David George Royffe
- 👤 Anthony Paul Charles Waters
- 👤 James Wrigg
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 01:04
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3693; A61M1/14; A61M1/30; A61M1/301; A61M1/303; A61M1/304; A61M1/305; A61M1/308; A61M1/3601; A61M1/3603; A61M1/3621; A61M1/3643; A61M1/3644; A61M1/3646; A61M1/3696; A61M2205/00; A61M2205/33; A61M2205/3306; A61M2205/3331; A61M2205/3344; A61M2205/3351; A61M2205/3355; A61M2205/3379; A61M2205/3393; B; B04; B04B; B04B5/00; B04B5/04; B04B5/0442; B04B2005/045
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
335 words
A blood fractionation system comprising a centrifugal rotor chamber, a separation chamber (1) adapted for placement within the rotor chamber, first and second blood component collection chambers (7, 8 respectively), first and second blood component conduits (4, 5 respectively) for establishing fluid communication between the separation chamber (1) and the first (7) and second (8) blood component collection chambers respectively, a donor conduit (9) capable of establishing fluid communication between a donor and the separation chamber (1). a return conduit (11) for establishing fluid communication between one of the blood component conduits (4, 5) and the donor conduit (9), a donor pump (17) capable of pumping fluid along the donor conduit (9), a blood component pump (18) capable of pumping fluid along one of the blood component conduits (4, 5), and system control means (19 - 31) including means (29, 30) responsive to the weight of fluid in each of the first (7) and second (8) blood component collection chambers, the system control means being adapted to control the system during an operating sequence comprising at least one primary blood component collection phase during which blood is drawn from a donor, the collection phase comprising at least one blood component collection cycle during which blood is continuously drawn from the donor and first blood component is conveyed along its respective blood component conduit (4) whilst flow along the second blood component conduit (5) is stopped, and then second blood component is conveyed along its respective blood component conduit (5) whilst flow along the first blood component conduit (4) is stopped, such that in operation flow of fluid along the first blood component conduit (4) is stopped, and flow of fluid along the second blood component conduit (5) initiated, by the collected first blood component increasing by a pre-determined weight, and flow of fluid along the second blood component conduit (5) is stopped, and flow of fluid along the first blood component conduit (4) initiated, by the collected second blood component increasing by a pre-determined weight.
Claim 2
Dependent Claim
335 words
A blood fractionation system comprising a centrifugal rotor chamber, a separation chamber (1) adapted for placement within the rotor chamber, first and second blood component collection chambers (7, 8 respectively), first and second blood component conduits (4, 5 respectively) for establishing fluid communication between the separation chamber (1) and the first (7) and second (8) blood component collection chambers respectively, a donor conduit (9) capable of establishing fluid communication between a donor and the separation chamber (1). a return conduit (11) for establishing fluid communication between one of the blood component conduits (4, 5) and the donor conduit (9), a donor pump (17) capable of pumping fluid along the donor conduit (9), a blood component pump (18) capable of pumping fluid along one of the blood component conduits (4, 5), and system control means (19 - 31) including means (29, 30) responsive to the weight of fluid in each of the first (7) and second (8) blood component collection chambers, the system control means being adapted to control the system during an operating sequence comprising at least one primary blood component collection phase during which blood is drawn from a donor, the collection phase comprising at least one blood component collection cycle during which blood is continuously drawn from the donor and first blood component is conveyed along its respective blood component conduit (4) whilst flow along the second blood component conduit (5) is stopped, and then second blood component is conveyed along its respective blood component conduit (5) whilst flow along the first blood component conduit (4) is stopped, such that in operation flow of fluid along the first blood component conduit (4) is stopped, and flow of fluid along the second blood component conduit (5) initiated, by the collected first blood component increasing by a pre-determined weight, and flow of fluid along the second blood component conduit (5) is stopped, and flow of fluid along the first blood component conduit (4) initiated, by the collected second blood component increasing by a pre-determined weight.
Claim 3
Dependent Claim
36 words
A blood fractionation system according to Claim 1, wherein the means responsive to the weight of fluid in each of the first (7) and second (8) blood component collection chambers includes electronic weight transducers (29, 30).
Claim 4
Dependent Claim
30 words
A blood fractionation system according to any one of the preceding claims, wherein the first blood component is a cellular component and the second blood component is a plasma component.
Claim 5
Dependent Claim
34 words
A blood fractionation system according to Claim 1, wherein the ratio of the pre-determined weight of collected first blood component to the pre-determined weight of collected second blood component is from 1.7:1 to 2.3:1.
Claim 6
Dependent Claim
24 words
A blood fractionation system according to Claim 1, wherein the pre-determined weight increase of collected first blood component is from 0.1 to 20 grams.
Claim 7
Dependent Claim
84 words
A blood fractionation system according to any one of the preceding claims, comprising a disposable blood fractionation pathway (1 - 15) including the separation chamber (1), the first (7) and second (8) blood component collection chambers, the first (4) and second (5) blood component conduits, the donor conduit (9) and the return conduit (11) and a blood fractionation apparatus (16 - 31) including the centrifugal rotor chamber, the donor pump (17), the blood component pump (18) and the system control means (19 - 31).
Claim 8
Dependent Claim
119 words
A blood component fractionation pathway (1 - 15), for use in association with a blood fractionation apparatus including a centrifugal rotor chamber, the pathway comprising a separation chamber (1) adapted for placement within the rotor chamber of the blood fractionation apparatus, first (7) and second (8) blood component collection chambers, first (4) and second (5) blood component conduits for establishing fluid communication between the separation chamber (1) and the first (7) and second (8) blood component collection chambers respectively, a donor conduit (9) capable of establishing fluid communication between a donor and the separation chamber (1), and a return conduit (11) for establishing fluid communication between one of the blood component conduits (4, 5) and the donor conduit (9).
Claim 9
Dependent Claim
119 words
A blood component fractionation pathway (1 - 15), for use in association with a blood fractionation apparatus including a centrifugal rotor chamber, the pathway comprising a separation chamber (1) adapted for placement within the rotor chamber of the blood fractionation apparatus, first (7) and second (8) blood component collection chambers, first (4) and second (5) blood component conduits for establishing fluid communication between the separation chamber (1) and the first (7) and second (8) blood component collection chambers respectively, a donor conduit (9) capable of establishing fluid communication between a donor and the separation chamber (1), and a return conduit (11) for establishing fluid communication between one of the blood component conduits (4, 5) and the donor conduit (9).
Claim 10
Dependent Claim
18 words
A blood fractionation pathway according to Claim 7, wherein the separation chamber (1) is substantially toroidal in shape.
Claim 11
Dependent Claim
20 words
A blood fractionation pathway according to Claim 8, wherein the separation chamber (1) comprises a tube sealed at both ends.
Claim 12
Dependent Claim
120 words
A blood fractionation pathway according to any one of Claims 7 to 9, wherein the first blood component conduit (4) terminates at a position adjacent to the wall (2) of the separation chamber (1) closest to the axis of centrifugation, the second blood component conduit (5) terminates at a position adjacent to the wall (3) of the separation chamber (1) furthest from the axis of centrifugation, and the donor conduit (9) terminates at a position substantially equidistant from said walls (2, 3). ll. A blood fractionation pathway according to any one of Claims 7 to 10, wherein the first blood component conduit (4) terminates within a blister (6) projecting inwardly from the separation chamber (1) towards the axis of centrifugation.
Claim 13
Dependent Claim
40 words
A blood fractionation pathway according to any one of Claims 7 to 11, wherein the donor conduit (9) is provided with a pressure pouch (14) which is capable of actuating a pressure sensor (19) provided in the blood fractionation apparatus.
Claim 14
Dependent Claim
25 words
A blood fractionation pathway according to any one of Claims 7 to 12, wherein the donor conduit (9) is provided with a filter pouch (15).
Claim 15
Dependent Claim
31 words
A blood fractionation pathway according to any of Claims 7 to 13, wherein the separation chamber (1) is provided on its internal surface with a plurality of longitudinal ribs (33, 34).
Claim 16
Dependent Claim
50 words
A blood fractionation pathway according to Claim 9, wherein the donor conduit (9) is connected to the separation chamber (1) at the opposite end of the separation chamber (1) to the end at which the first (4) and second (5) blood component conduits are connected to the separation chamber (1).
Claim 17
Dependent Claim
40 words
A blood fractionation pathway according to any one of Claims 7 to 15, wherein a portion of the pathway including that portion which undergoes angular motion is made of torsion-stiff but flexible material and the remainder of a compliant material.
Claim 18
Dependent Claim
22 words
A blood fractionation pathway according to Claim 16, wherein the torsion-stiff but flexible material is nylon and the compliant material is polyvinylchloride.
Claim 19
Dependent Claim
22 words
A blood fractionation apparatus for use in association with a blood fractionation pathway according to any one of Claims 7 to 17.
Claim 20
Independent Claim
67 words
A method of fractionating blood comprising separating the blood into first and second blood components in a separation chamber (1) and collecting said first and second blood components in at least one collection cycle during which blood is continuously drawn from a donor, the collection cycle comprising conveying first one and then the other blood component to first (7) and second (8) blood component collection chambers respectively.
Claim 21
Independent Claim
67 words
A method of fractionating blood comprising separating the blood into first and second blood components in a separation chamber (1) and collecting said first and second blood components in at least one collection cycle during which blood is continuously drawn from a donor, the collection cycle comprising conveying first one and then the other blood component to first (7) and second (8) blood component collection chambers respectively.
Claim 22
Independent Claim
99 words
A method of fractionating blood comprising separating the blood into first and second blood components in a separation chamber (1) and collecting said first and second blood components in first (7) and second (8) blood component collection chambers respectively, wherein the method includes a phase during which no blood is drawn from a donor and one of said first and second blood components is collected by displacing it from the separation chamber (1) by returning the other one of said first and second blood components from its respective blood component collection chamber (7, 8) to the separation chamber (1).
Claim 23
Independent Claim
99 words
A method of fractionating blood comprising separating the blood into first and second blood components in a separation chamber (1) and collecting said first and second blood components in first (7) and second (8) blood component collection chambers respectively, wherein the method includes a phase during which no blood is drawn from a donor and one of said first and second blood components is collected by displacing it from the separation chamber (1) by returning the other one of said first and second blood components from its respective blood component collection chamber (7, 8) to the separation chamber (1).
Claim 24
Independent Claim
86 words
A method of fractionating blood comprising separating the blood into first and second blood components in a separation chamber (1) and collecting said first and second blood components in first (7) and second (8) blood component collection chambers respectively, wherein the method includes a final reinfusion phase in which the contents of the separation chamber (1) are conveyed to one of the first (7) and second (8) blood component collection chambers and the contents of that blood component collection chamber are then returned to the donor.
Claim 25
Independent Claim
86 words
A method of fractionating blood comprising separating the blood into first and second blood components in a separation chamber (1) and collecting said first and second blood components in first (7) and second (8) blood component collection chambers respectively, wherein the method includes a final reinfusion phase in which the contents of the separation chamber (1) are conveyed to one of the first (7) and second (8) blood component collection chambers and the contents of that blood component collection chamber are then returned to the donor.
References Cited (Backward Citations)
No citation records indexed.
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