Patent EP0212745A2 successfully refreshed from Google Patents.
EP0212745A2
Expired / Lapsed
EP
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Drug particles having constant release
Assignee: Procter and Gamble Co
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Filing: 1986-08-07
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Granted: —
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Expires: 2006-08-07
Abstract
Abstract Drug particles are disclosed which reduce the variation in dissolution rate with time frequently found with sustained-release dosage forms. This is achieved by coating the drug particle with an inner coating of an enteric material and an outer coating of a material which is insoluble at any pH and acts as a diffusion barrier for the drug active.
Inventors
- 👤 Gary Robert Kelm
- 👤 Richard Edward Keim
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 12:51
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
52 words
Drug particles comprising: (a) a propionic acid derivative core; (b) an inner coating of an enteric material selected from the group consisting of acrylic polymers and copolymers; and (c) an outer coating of a material insoluble in the stomach and intestines selected from the group consisting of methacrylic acid polymers and copolymers.
Claim 2
Dependent Claim
52 words
Drug particles comprising: (a) a propionic acid derivative core; (b) an inner coating of an enteric material selected from the group consisting of acrylic polymers and copolymers; and (c) an outer coating of a material insoluble in the stomach and intestines selected from the group consisting of methacrylic acid polymers and copolymers.
Claim 3
Dependent Claim
26 words
Drug particles according to Claim 1 wherein the propionic acid derivative is selected from the group consisting of ibuprofen, indoprofen, flurbiprofen, fenoprofen, fluprofen, ketoprofen and suprofen.
Claim 4
Dependent Claim
33 words
Drug particles according to Claim 2 wherein the inner coating is present at a level of from about 2% to about 30% of the total weight of the core and the inner coating.
Claim 5
Dependent Claim
36 words
Drug particles according to Claim 3 wherein the outer coating is present at a level of from about 2% to about 20% of the total weight of the core, the inner coating and the outer coating.
Claim 6
Dependent Claim
13 words
Drug particles according to Claim 4 wherein the propionic acid derivative is ibuprofen.
Claim 7
Dependent Claim
28 words
Drug particles according to Claim 5 wherein the inner coating is based on polymethacrylic acid and acrylic acid esters and has a mean molecular weight of about 250,000.
Claim 8
Dependent Claim
25 words
Drug particles according to Claim 6 wherein the outer coating is based on polymethacrylic acid esters and has a mean molecular weight of about 800,000.
References Cited (Backward Citations)
No citation records indexed.
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