EP0204476A1
Expired / Lapsed
EP
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Controlled release delivery system for macromolecules
Assignee: International Minerals and Chemical Corp
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Filing: 1986-05-23
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Granted: —
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Expires: 2006-05-23
Abstract
Abstract Acontrolled release implant composition which compris. es a core of macromolecular drug and a water insoluble polymer and a homogeneous outer polymeric membrane formed by coating said core with solution of a water insoluble polymerand a watersoluble pore-forming agent in an organic solvent, followed by removal of said solvent.
Inventors
- 👤 Mohamad D. Shalati
- 👤 Kallidaikurichi N. Sivaramakrishnan
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 04:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/28; A61K9/2806; A61K9/2833; A61K9/2853; Y; Y10; Y10S; Y10S424/00; Y10S424/07
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
69 words
A composition suitable for implantation which provides controlled release of a macromolecular drug, said composition comprising a core of the macromolecular drug and a water insoluble polymer; and a homogeneous pore-forming outer polymeric membrane, said membrane being formed by coating said core with a solution of a water insoluble high molecular weight polymer and a water soluble pore-forming agent in an organic solvent, followed by removal of said solvent.
Claim 2
Dependent Claim
69 words
A composition suitable for implantation which provides controlled release of a macromolecular drug, said composition comprising a core of the macromolecular drug and a water insoluble polymer; and a homogeneous pore-forming outer polymeric membrane, said membrane being formed by coating said core with a solution of a water insoluble high molecular weight polymer and a water soluble pore-forming agent in an organic solvent, followed by removal of said solvent.
Claim 3
Dependent Claim
20 words
A composition as claimed in claim 1, wherein said macromolecular drug has a molecular weight of at least about 2000.
Claim 4
Dependent Claim
25 words
A composition as claimed in claim 1 or claim 2, wherein said macromolecular drug is a native or recombinant bioactive protein or an analog thereof.
Claim 5
Dependent Claim
20 words
A composition as claimed in claim 3, wherein said protein is native porcine growth hormone or a recombinant analog thereof.
Claim 6
Dependent Claim
28 words
A composition as claimed in any one of claims 1 to 4, wherein said core polymer is selected from the group consisting of polyactic acid, ethylcellulose, and polycaprolactone.
Claim 7
Dependent Claim
30 words
A composition as claimed in any one of claims 1 to 5, wherein said water soluble pore-forming agent is selected from the group consisting of dimethyl tartrate and diethyl tartrate.
Claim 8
Dependent Claim
36 words
A composition as claimed in any one of claims 1 to 6, wherein said water insoluble high molecular weight polymer in said polymeric membrane is selected from the group consisting of polylactic acid, ethylcellulose and polycaprolactone.
Claim 9
Independent Claim
65 words
A method of preparing a composition suitable for implantation which provides controlled release of a macromolecular drug comprising: (a) forming a mixure of the macromolecular drug and a water insoluble polymer into a pellet; (b) coating said pellet with a solution of a water insoluble high molecular weight polymer and a water soluble pore-forming agent in an organic solvent; and (c) removing said organic solvent.
Claim 10
Independent Claim
65 words
A method of preparing a composition suitable for implantation which provides controlled release of a macromolecular drug comprising: (a) forming a mixure of the macromolecular drug and a water insoluble polymer into a pellet; (b) coating said pellet with a solution of a water insoluble high molecular weight polymer and a water soluble pore-forming agent in an organic solvent; and (c) removing said organic solvent.
Claim 11
Dependent Claim
20 words
A method as claimed in claim 8 wherein said macromolecular drug has a molecular weight of at least about 2000.
Claim 12
Dependent Claim
25 words
A method as claimed in claim 8 or claim 9 wherein said macromolecular drug is a native or recombinant bioactive protein or an analog thereof.
Claim 13
Dependent Claim
20 words
A method as claimed in claim 10, wherein said protein is native porcine growth hormone or a recombinant analog thereof.
Claim 14
Independent Claim
28 words
A method as claimed in any one of claims 8 to 11, wherein said pellet polymer is selected from the group consisting of polyactic acid, ethylcellulose and polycaprolactone.
Claim 15
Independent Claim
30 words
A method as claimed in any one of claims 8 to 12, wherein said water soluble pore-forming agent is selected from the group consisting of dimethyl tartrate and diethyl tartrate.
Claim 16
Independent Claim
42 words
A method as claimed in any one of claims 8 to 13. wherein said water insoluble, high molecular weight polymer present in the organic solvent solution used in step (b) is selected from the group consisting of polylactic acid, ethylcellulose and polycaprolactone.
Claim 17
Independent Claim
23 words
A method as claimed in any one of claims 8 to 14 in which the said composition is for subcutaneous inplantation in animals.
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